5-Florourasil ve folinik asit tedavisi alan kolon karsinomlu olguda tedavi sonrası skleroderma

Yıl 2014, Cilt: 39 Sayı: 2, 362 - 364, 22.07.2014

Didem Arslan Taş Ahmet Eftal Yüce Özgür Özyılkan

https://doi.org/10.17826/cutf.38509

Öz

Sistemic sclerosis is a connective tissue disease which is characterized by the increase amount of collagene in subcutaneous tissue and internal organs. Several chemical agents and environmental factors are accused fort he etiopathogenesis however the etiology is not clear. There is limited data abput the increased frequency of colon carcinoma in the cases with sistemic sclerosis. There are 2 cases in the literature about the association between scleroderma and 5-fluorouracil which is used for the treatment of colon carcinoma. Similar clinical course and autoantibody positivity was also reported in a patient with tymic carcinoma who had been treated with 5-FU and folinic acid. In this article, a 51-year-old woman who developed scleroderma after 5-FU and folinic acid therapy which had been started for colon carcinoma has been reported.

Anahtar Kelimeler

Scleroderma, colon cancer, 5 fluorouracil

Scleroderma after 5-fluorouracil and folinic acid therapy in a patient with colon carcinoma

Öz

Skleroderma cilt altında ve iç organlarda artmış kollajen birikimi ile karakterize bir bağ dokusu hastalığıdır. Etiyolojisi tam aydınlatılamamakla birlikte bazı kimyasal ajanların ve çevresel faktörlerin etyopatogenezde rol oynadığı kabul edilmektedir. Progresif sistemik skleroderma olan olgularda gastrointestinal kanal karsinomlarının arttığına dair sınırlı veri bulunmaktadır. Kolon karsinomu tedavisinde kullanılan 5-florourasil ile skleroderma ilişkisine dair literatürde sadece iki olgu bildirilmiştir. 5-florourasil ve folinik asit tedavisi verilen timik karsinomlu bir olguda ise skleroderma benzeri klinik tablo ve otoantikor pozitifliği bildirilmiştir. Bu yazıda, 51 yaşında kolon karsinomu tanısıyla 3 kür 5-florourasil ve folinik asit tedavisi alan ve daha sonra scleroderma geliştiren bir olgu sunulmuştur.

Anahtar Kelimeler

Skleroderma, kolon kanseri, 5 florourasil

Kaynakça

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• Yazışma Adresi / Address for Correspondence: Dr. Didem Arslan Taş Çukurova Üniversitesi Tıp Fakültesi, Romatolojiİmmünoloji Bilim Dalı 01330 Balcalı-ADANA
• Email: [e-mail] geliş tarihi/received :11.04.2013 kabul tarihi/accepted:27.05.2013