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Comparative Evaluation of Cases with CommunityAcquired Infective Endocarditis and Health CareAssociated Infective Endocarditis

Year 2015, Volume: 40 Issue: 1, 91 - 97, 09.09.2015
https://doi.org/10.17826/cutf.53281

Abstract

Purpose: The present study aimed to comparatively evaluate the cases with health care-associated infective endocarditis and the cases with community-acquired infective endocarditis. Material and Methods: Of the cases followed for infective endocarditis (IE), 21 (40 %) had health care-associated infective endocarditis and 31 (60 %) community-acquired infective endocarditis. Results: Comparing the cases with community acquired infective endocarditis and the cases with health careassociated infective endocarditis, it was determined that advanced age (58.0 ± 15.1 years vs. 41.3± 14.4 years, P= 0.000), presence of chronic renal insufficiency (P= 0.001) and diabetes mellitus (P= 0.016) as concomitant diseases, being previously hospitalized (P= 0.0001), hemodialysis in terms of diagnostic and therapeutic interventions (P= 0.022), presence of central venous catheter (P= 0.022), and undergone intervention for gastrointestinal system (P= 0.060),as well as laboratory results including positive blood culture growth for S. aureus and Enterococcus (P= 0.037), and complications such as development of embolic event (P= 0.008), spondylodiscitis (P= 0.034) and stroke (P= 0.007) were statistically significantly more common in health care-associated infective endocarditis cases. Whilst mortality was higher in health care-associated infective endocarditis cases (28.6 %), it was determined that there was no statistically significant difference between the groups. Conclusion: Health care-associated infective endocarditis is a disease that is more common in the patients at advanced age, with concomitant disease and the history of exposing invasive procedures in the past for diagnostic and therapeutic purpose, and it is a disease with high morbidity and mortality that courses with serious complications.

References

  • Moreillon P, Que YA. Infective endocarditis. Lancet. 2004;363:139–49.
  • Hoen B, Alla F, Selton-Suty C, Béguinot I, Bouvet A, Briançon S et al. Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA. 2002;288:75–81.
  • Hill EE, Herijgers P, Claus P, Vanderschueren S, Herregods MC, Peetermans WE. Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study. Eur Heart J. 2007;28:196–203.
  • Benito N, Miró JM, de Lazzari E, Cabell CH, del Río A, Altclas J et al; ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) Investigators. Health care-associated native valve endocarditis: importance of non-nosocomial acquisition. Ann Intern Med. 2009;150:586-94.
  • Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40: 373-83.
  • Lomas JM, Martínez-Marcos FJ, Plata A, Ivanova R, Gálvez J, Ruiz J et al. Healthcare-associated infective endocarditis: an undesirable effect of healthcare universalization. Clin Microbiol Infect. 2010;16:1683-90.
  • Ben-Ami R, Giladi M, Carmeli Y, Orni-Wasserlauf R, Siegman-Igra Y. Hospital-acquired infective endocarditis: should the definition be broadened? Clin Infect Dis. 2004;38:843-50.
  • Fernández-Hidalgo N, Almirante B, Tornos P, Pigrau C, Sambola A, Igual A et al. Contemporary epidemiology and prognosis of health care- associated infective endocarditis. Clin Infect Dis. 2008;47:1287-97.
  • Que YA, Moreillon P. Infective endocarditis. Nat Rev Cardiol. 2011;8:322-36.
  • Cabell CH, Jollis JG, Peterson GE Corey GR, Anderson DJ, Sexton DJ et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med. 2002;162:90-4.
  • Hoen B. Infective endocarditis: a frequent disease in dialysis patients. Nephrol Dial Transplant. 2004;19:1360-2.
  • Leone S, Ravasio V, Durante-Mangoni E, Crapis M, Carosi G, Scotton PG et all. Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian Study on Endocarditis. Infection. 2012;40:527-35.
  • Thuny F, Avierinos JF, Tribouilloy C, Giorgi R, Casalta JP, Milandre L et al. Impact of cerebrovascular complications on mortality and neurologic outcome during infective endocarditis: a prospective multicentre study. Eur Heart J. 2007;28:1155-61.

Toplumdan Edinilmiş ve Sağlık Hizmeti İlişkili İnfektif Endokardit Olgularının Karşılaştırmalı Değerlendirilmesi

Year 2015, Volume: 40 Issue: 1, 91 - 97, 09.09.2015
https://doi.org/10.17826/cutf.53281

Abstract

Amaç: Çalışmamızda sağlık bakımı ilişkili infektif endokardit ile toplumdan edinilmiş infektif endokardit olgularımızın karşılaştırılmalı olarak değerlendirilmesi amaçlanmıştır. Materyal ve Metod: Olgularımızın 21 (% 40)’inin sağlık bakımı ilişkili infektif endokardit ve 31 (% 60)’inin de toplumdan edinilmiş infektif endokardit olduğu belirlendi Araştırma Makalesi / Research Article 91 Kurşun et al. Cukurova Medical Journal Bulgular: Çalışmamızda sağlık bakımı ilişkili infektif endokardit ile toplumdan edinilmiş infektif endokardit olgularımızın karşılaştırılmalı olarak değerlendirilmesi amaçlanmıştır. Toplumdan edinilmiş infektif endokardit ile sağlık bakımı ilişkili infektif endokardit olguları karşılaştırıldığında; ileri yaşın (58.0 ± 15.1 yıl ve 41.3 ± 14.4 yıl, P= 0.000), eşlik eden hastalıklar açısından kronik böbrek yetmezliğinin (P= 0.001), ve diyabetes mellitus varlığının (P= 0.016), önceden hastanede yatmış olmanın (P= 0.0001), tanı ve tedavi amaçlı uygulanan girişimler açısından özellikle hemodiyaliz uygulamalarının (P= 0.022), santral kateter varlığı (P= 0.022), ile gastrointestinal sisteme girişim yapılmasının (P= 0.060), laboratuvar bulguları açısından kan kültüründe S.aureus ve Enterokok üremesinin (P= 0.037), ve son olarak komplikasyonlar açısından ise embolik olay (P= 0.008), spondilodiskit (P= 0.034) ve stroke gelişiminin (P= 0.007) sağlık bakımı ilişkili infektif endokardit olgularında istatiksel olarak da anlamlı olacak şekilde daha yüksek olduğu saptandı. Sonuç: Mortalite sağlık bakımı ilişkili infektif endokardit olgularında (% 28.6 ) daha yüksek bulunurken iki grup arasında bu yönde istatistiksel olarak fark olmadığı tespit edildi. Sonuç olarak, sağlık bakımı ilişkili infektif endokardit, ileri yaşta ve eşlik eden hastalığa sahip, öykülerinde tanı ve tedavi amaçlı invaziv girişim uygulanan ciddi komplikasyonlar ile seyreden ve yüksek mortalite oranına sahip bir hastalıktır

References

  • Moreillon P, Que YA. Infective endocarditis. Lancet. 2004;363:139–49.
  • Hoen B, Alla F, Selton-Suty C, Béguinot I, Bouvet A, Briançon S et al. Changing profile of infective endocarditis: results of a 1-year survey in France. JAMA. 2002;288:75–81.
  • Hill EE, Herijgers P, Claus P, Vanderschueren S, Herregods MC, Peetermans WE. Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study. Eur Heart J. 2007;28:196–203.
  • Benito N, Miró JM, de Lazzari E, Cabell CH, del Río A, Altclas J et al; ICE-PCS (International Collaboration on Endocarditis Prospective Cohort Study) Investigators. Health care-associated native valve endocarditis: importance of non-nosocomial acquisition. Ann Intern Med. 2009;150:586-94.
  • Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40: 373-83.
  • Lomas JM, Martínez-Marcos FJ, Plata A, Ivanova R, Gálvez J, Ruiz J et al. Healthcare-associated infective endocarditis: an undesirable effect of healthcare universalization. Clin Microbiol Infect. 2010;16:1683-90.
  • Ben-Ami R, Giladi M, Carmeli Y, Orni-Wasserlauf R, Siegman-Igra Y. Hospital-acquired infective endocarditis: should the definition be broadened? Clin Infect Dis. 2004;38:843-50.
  • Fernández-Hidalgo N, Almirante B, Tornos P, Pigrau C, Sambola A, Igual A et al. Contemporary epidemiology and prognosis of health care- associated infective endocarditis. Clin Infect Dis. 2008;47:1287-97.
  • Que YA, Moreillon P. Infective endocarditis. Nat Rev Cardiol. 2011;8:322-36.
  • Cabell CH, Jollis JG, Peterson GE Corey GR, Anderson DJ, Sexton DJ et al. Changing patient characteristics and the effect on mortality in endocarditis. Arch Intern Med. 2002;162:90-4.
  • Hoen B. Infective endocarditis: a frequent disease in dialysis patients. Nephrol Dial Transplant. 2004;19:1360-2.
  • Leone S, Ravasio V, Durante-Mangoni E, Crapis M, Carosi G, Scotton PG et all. Epidemiology, characteristics, and outcome of infective endocarditis in Italy: the Italian Study on Endocarditis. Infection. 2012;40:527-35.
  • Thuny F, Avierinos JF, Tribouilloy C, Giorgi R, Casalta JP, Milandre L et al. Impact of cerebrovascular complications on mortality and neurologic outcome during infective endocarditis: a prospective multicentre study. Eur Heart J. 2007;28:1155-61.
There are 13 citations in total.

Details

Primary Language English
Journal Section Research
Authors

Ebru Kurşun This is me

Tuba Turunç This is me

Yusuf Demiroğlu This is me

Turhan Togan This is me

Göknur Tekin This is me

Hande Arslan This is me

Publication Date September 9, 2015
Published in Issue Year 2015 Volume: 40 Issue: 1

Cite

MLA Kurşun, Ebru et al. “Comparative Evaluation of Cases With CommunityAcquired Infective Endocarditis and Health CareAssociated Infective Endocarditis”. Cukurova Medical Journal, vol. 40, no. 1, 2015, pp. 91-97, doi:10.17826/cutf.53281.