POEMS Syndrome: Two Case Reports

Yıl 2015, Cilt: 40 Sayı: 2, 373 - 378, 28.09.2015

Turgay Demir , Duygu Kurt Ayşe Koç Ahmet Evlice

https://doi.org/10.17826/cutf.69971

Öz

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is an uncommon condition related to a paraneoplastic syndrome secondary to an underlying plasma cell disorder. Patients always present with polyneuropathy. Herein we discussed two cases who were presented with polyneuropathy. POEMS syndrome should be considered among the differential diagnoses of all patients with polyneuropathy.

Anahtar Kelimeler

POEMS, polyneuropathy, paraneoplastic syndrome

POEMS Sendromu: İki Olgu Sunumu

Öz

Polinöropati, organomegali, endokrinopati, M proteini ve deri değişiklikleri ile karakterize olan POEMS sendromu nadir görülen bir paraneoplastik sendromdur. Genellikle klinik tablo polinöropati ile başlar. Burada polinöropati kliniği ile başvuran ve POEMS tanısı alan iki olgu tartışılmıştır. Polinöropatisi tanısı alan tüm olgularda ayırıcı tanıda POEMS sendromu da dikkate alınmalıdır.

Anahtar Kelimeler

POEMS, polinöropati, paraneoplastik sendrom

Kaynakça

• Driedger H, Pruzanski W. Plasma cell neoplasia with peripheral polyneuropathy. A study of five cases and a review of the literature. Medicine (Baltimore) 1980;59:301-10.
• Bardwick PA, Zvaifler NJ, Gill GN, et al. Plazma cell discrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes: the POEMS syndrome. Report of two cases and review of the literature. Medicine (Baltimore). 1980;59:311- 22.
• Nakanishi T, Sobue I, Toyokura Y, et al. The Crow- Fukase syndrome: a study of 102 cases in Japan. Neurology. 1984;34:712-20.
• Sung JY. Patterns of nerve conduction abnormalities in POEMS syndrome. Muscle Nerve. 2002;26:189- 93.
• Civile O. La sindrome POEMS. Minerva Med. 2001;92:43-7.
• Lesprit P, Godeau B, Authier FJ, et al. Pulmoner hypertension in POEMS: a new feature mediated by citokines. Am J Respir Crit Care Med. 1998;157:907- 11.
• Dispenzieri A. POEMS syndrome. Hematology Am Soc Hematol Educ Program. 2005:360-7.
• Dispenzieri A, Kyle RA, Lacy MQ, et al. POEMS syndrome: definitions and long-term outcome. Blood. 2003;101:2496-506.
• Arimura K. [Increased vascular endothelial growth factor (VEGF) is causative in Crow-Fukase syndrome]. Rinsho Shinkeigaku. 1999;39:84-5.
• Seven G ve ark. POEMS Sendromu. Güncel Gastroenteroloji. 2008;12:59-64.
• Soubrier MJ, Duobst JJ, Sauveze BJ and the French Study Group of 25 cases and a review of the literature. French Study Group on POEMS Syndrome. Am J Med. 1994;97:543-53.
• Iwashita H, Ohnishi A, Asada M, et al. 17. Orefice G, Morra VB, De Michele G, et al. POEMS Polyneuropathy, skin hyperpigmentation, edema, and hypertrichosis in localized osteosclerotic myeloma. Neurology. 1977;27:675-81.
• Morley JB, Schwieger AC. The relation between chronic polyneuropathy and osteosclerotic myeloma. J Neurol Neurosurg Psychiatry. 1967;30:432-42.
• Reitan JB, Pape E, Fossa SD, et al. Osteosclerotic myeloma with polyneuropathy. Acta Med Scand.1980;208:137-44.
• Ku A, Lachmann E, Tunkel R, Nagler W. Severe polyneuropathy: initial manifestation of Castleman’s disease associated with POEMS syndrome. Arch Phys Med Rehabil. 1995;76:692-4.
• Cabezas-Agricola JM, Lado-Abeal JJ, Otero-Anton E, et al. Hypoparathyroidism in POEMS syndrome. Lancet. 1996;347:701-2. syndrome: clinical, pathological and immunological study of a case. Neurol Res. 1994;16:477-80.
• Wong VA, Wade NK. POEMS syndrome: an unusual cause of bilateral optic disk swelling. Am J Ophthalmol. 1998;126:452-4.
• Ganti AK, Pipinos I, Culcea E, et al. Successful hematopoietic stem-cell transplantation in multicentric Castleman disease complicated syndrome. Am J Hematol. 2005;79:206-10. by POEMS
• Imai N, Kitamura E, Tachibana T, et al. Efficacy of autologous peripheral blood stem cell transplantation in POEMS syndrome with polyneuropathy. Intern Med. 2007;46:135-8.
• K. Kang, K. Chu, D.-E. Kim, S.-W. Jeong, J.-W. Lee, and J.-K. Roh, “POEMS syndrome associated with ischemic stroke,” Archives of Neurology., 2003;60:745–49.