Hematopoetik Kök Hücre Transplantasyonu İle Tetiklenen Ovaryan Yetmezliğe Bağlı Gelişen Labial Adezyon
Abstract
Labial adezyon, labium major ve / veya minör lerin tamamen veya kısmi birleşmesi sonrası oluşan bir hastalıktır. Genellikle arka forşette gelişir ve bazen de üretra ağzına ve klitorise kadar uzanım gösterebilir. Labial adezyon daha çok puberte öncesi kız çocuklarında görülürken, 13-23 aylık yaş gurubunda pik yapar. Labial adezyona sebep olan faktörler bilinmemektedir. Hipoöstrojene bağlı gelişebilen vajinal irritasyon veya inflamasyon bu duruma sebep olabilecek hipotez olarak düşünülmektedir. Bu olguda hematopoetik kök hücre transplantasyonu sonrası gelişen ovaryan yetmezliğe bağlı gelişen labial adezyon sunuldu.
References
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- Cheng YC, Takagi M, Milbourne A, Champlin RE, Ueno NT. Phase II study of gonadotropin-releasing hormone analog for ovarian function preservation in hematopoietic stem cell transplantation patients. Oncologist. 2012;17:233–8.
- Jadoul P, Donnez J. How does bone marrow transplantation affect ovarian function and fertility? Curr Opin Obstet Gynecol.. 2012;24:164-71.
Abstract
Labial adhesion is a disease which occurs after complete or partial fusion of labium majors and / or minors. It usually originates at the posterior fourchette and sometimes progresses towards urethral opening and clitoris. Incidence of labial adhesion is most frequent in prepubescent girls with a peak incidence at the age of 13 – 23 months. The factors that cause labial adhesion remain unknown. Vaginal irritation or inflammation process with underlying hypoestrogenism can cause this disease.We present a case who developed labial adhesion due to ovarian failure after hematopoietic stem cell transplantation.
References
- Von Hebra F. Ueber Schwangerschaft, des Wochenbettes und bei Uterinalkrankheiten der Frauen zu beobach-tende Hautkrankheiten. 1872;22:1197–1202. einzelne während Wien Med Wochen-schr.
- Sauer GC, Geha BJ. Impetigo herpetiformis. Arch Dermatol. 1961;83:173–80
- Opipari AW Jr. Management quandary. Labial agglutination in a teenager. J Pediatr Adolesc Gynecol. 2003;16:61-2.
- Muram D. Treatment of prepubertal girls with labial adhesions. J Pediatr Adolesc Gynecol. 1999;12:67- 70.
- Bacon JL. Prepubertal labial adhesions: evaluation of a referral population. Am J Obstet Gynecol. 2002;187:327-31; discussion 332.
- Velander MH, Mikkelsen DB, Bygum A. Labial agglutination in a prepubertal girl: effect of topical oestrogen. Acta Derm Venereol. 2009;89:198-9.
- Leung AK, Robson WL, Kao CP, Liu EK, Fong JH. Treatment of labial fusion with topical estrogen therapy. ClinPediatr. 2005;44:245–7.
- Myers JB, Sorensen CM, Wisner BP, Furness PD, Passamaneck M, Koyle MA. Betamethasone cream for the treatment of pre-pubertal labial adhesions. J Pediatr Adolesc Gynecol. 2006;19:407–11.
- Cheng YC, Takagi M, Milbourne A, Champlin RE, Ueno NT. Phase II study of gonadotropin-releasing hormone analog for ovarian function preservation in hematopoietic stem cell transplantation patients. Oncologist. 2012;17:233–8.
- Jadoul P, Donnez J. How does bone marrow transplantation affect ovarian function and fertility? Curr Opin Obstet Gynecol.. 2012;24:164-71.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Report |
| Authors | |
| Publication Date | September 30, 2015 |
| Published in Issue | Year 2015 Volume: 40 Issue: 3 |
