Psödoeksfoliasyon ve aköz hümörde matriks metalloproteinaz-2 düzeyi

Yıl 2019, Cilt: 44 Sayı: 3, 835 - 839, 30.09.2019

Emine Çiloğlu Neşe Doğan Nusret Özdemir

https://doi.org/10.17826/cumj.507221

Öz

Amaç: Bu çalışmanın amacı primer açık açılı glokom (PAAG), psödoeksfoliasyon sendromu (PES), psödoeksfoliatif glokom (PEG) hastalarında aköz hümörde matriks metalloproteinaz-2 (MMP-2) düzeylerini araştırmaktır.

Gereç ve Yöntem: Bu prospektif çalışmada PES, PEG, PAAG' lu olgular ile kontrol grubunda yer alan kataraktlı olgularla birlikte toplam 97 hastanın 117 gözünden alınan humör aköz örneklerinde MMP-2 düzeyleri immünoassay ELİSA yöntemi ile ölçüldü. Her grup kontrol grubu ve birbirleri ile karşılaştırıldı.

Bulgular: Humörde aközde tespit edilen total MMP-2 seviyeleri; kontrol grubunda ortalama 56.69±51.3 ng/ml, PES grubunda 97.84±81.12 ng/ml, PEG grubunda 108.00±83.7 ng/ml ve PAAG grubunda 83.89±71.68 ng/ml idi. PES, PEG ve PAAG grubunda bulunan MMP-2 seviyeleri, kontrol grubu ile karşılaştırıldığında yüksek bulunmasına rağmen PES, PEG ve PAAG grupları arasında humör aköz ortalama MMP-2 düzeylerinde istatistiksel olarak anlamlı fark yoktu.

Sonuç: Çalışmamızda PE gruplarında, hem kontrol grubu hem de PAAG’lu gruba göre ortalama MMP-2 seviyelerinin yüksek olduğu bulundu. Ancak PE’lu grup ile PAAG grubu arasında istatistiksel anlamlı bir fark yoktu. 

Sonuç olarak PE’lu olgularda MMP-2 döngüsündeki bozukluğun PEM birikiminde önemli mekanizmalardan biri olabileceği ve GİB artışında da önemli rol oynadığı kanısına varıldı.  

Anahtar Kelimeler

Matriks metalloproteinaz-2, psödoeksfoliasyon sendromu, psödoeksfoliatif glokom, primer açık açılı glokom.

Pseudoexfoliation and level of matrix metalloproteinase-2 in the aqueous humor

Öz

Purpose: The aim of this study was to investigate the metalloproteinase-2 (MMP-2) levels in aqueous humor of patients with primary open-angle glaucoma (POAG), pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PEG) .

Materials and Methods: In this prospective study, MMP-2 levels were measured by immunoassay ELISA method in humorous aqueous samples taken from 117 eyes of 97 patients with PES, PEG, PAAG cases and cataract cases in the control group (CG). Each group was compared with the control group and each other.

Results: The mean total MMP-2 levels detected in aqueous humor were 56.69 ± 51.3 ng / ml in the CG,  97.84 ± 81.12 ng / ml in the PES group, 108.00 ± 83.7 ng / ml in the PEG group and 83.89 ± 71.68 ng / ml in the POAG group. Despite the high levels of MMP-2 in the PES, PEG and POAG groups compared with the CG, there was no statistically significant difference for mean MMP-2 levels in aqueous humor between the PES, PEG and PAAG groups.

Conclusion: In our study it was found that the mean MMP-2 levels were higher in the PE groups than both CG and POAG group. However, there was no statistically significant difference between the PE group and the POAG group. It has been concluded that the distruption of the MMP-2 turnover may be one of the important mechanisms in PEM accumulation in cases with PE and plays an important role in the IOP increase.

Anahtar Kelimeler

matrix metolloproteinase-2, pseudoexfoliation syndrome, pseudoexfoliative glaucoma

Kaynakça

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