Acute angle closure glaucoma induced by selective serotonin reuptake inhibitor, and reversed by agomelatine

Year 2019, Volume: 44 Issue: 4, 1520 - 1523, 29.12.2019

Mahmut Onur Karaytuğ , Mehmet Emin Demirkol , Lut Tamam

https://doi.org/10.17826/cumj.572186

Abstract

Agomelatine, a MT1 (Melatonin) and MT2 receptor agonist and 5-HT2C (5-Hidroksitriptamin)  antagonist, is an antidepressant agent used in the treatment of major depressive disorders. Intraocular pressure lowering effect of melatonin and its analogues have been demonstrated in a few experimental studies. In the present case report, we have documented the reversal of angle closure glaucoma by oral agomelatine in a patient with major depressive disorder under selective serotonine reuptake inhibitor treatment.  The patient, who had previously been diagnosed with glaucoma, was also receiving antiglaucomatous treatment.

Selektif serotonin geri alım inhibitörünün neden olduğu ve agomelatin ile düzelen akut açı kapanması glokomu

Abstract

ir MT1 ve MT2 reseptör agonisti ve 5-HT2C antagonisti olan agomelatin, majör depresif bozukluk tedavisinde kullanılan bir antidepresandır. Melatoninin ve analoglarının göz içi basıncı düşürücü etkisi birkaç deneysel çalışmada gösterilmiştir. Bu olgu sunumunda, oral agomelatin tedavisi ile düzelen açı kapanması glokomu aynı anda selektif serotonin geri alım inhibitörü alan majör depresif bozukluk tanılı bir hastada anlatılmaktadır. Daha önce glokom teşhisi konan hastaya ayrıca antiglokomatöz tedavi uygulanmıştır.

Keywords

Agomelatine, Angle closure glaucoma

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