Predictive values of lamina cribrosa depth and ganglion cell complex thickness in early diagnosis of glaucoma

Yıl 2022, Cilt: 47 Sayı: 1, 259 - 265, 31.03.2022

Şule Barman Kakil Elif Erdem İbrahim İnan Harbiyeli Meltem Yağmur

https://doi.org/10.17826/cumj.1029547

Öz

Purpose: Evaluation of ganglion cell complex measurement and the use of parameters of lamina cribrosa depth in early diagnosis and progression of patients with suspected glaucoma.
Materials and Methods: Measurements were taken with Heidelberg Spectralis Spectral Domain Optical Coherence Tomography from patients in both groups. Ganglion cell complex thicknesses measured with segmentation analysis. Lamina cribrosa depths were measured by using optic nerve head images of the glaucoma suspected group and the control group.
Results: Thirty-one glaucoma suspect patients and 42 healthy individuals were included in the study. The thickness of the ganglion cell layer was 11.46  in the glaucoma suspect group, and it was 12.19  in the control group. Mean lamina cribrosa depth was 579.3  in the glaucoma suspected group and 399.62  in the control group.
Conclusion: Optical coherence tomography helps ophthalmologists for the diagnosis and follow-up of glaucoma patients, and non-invasively measured ganglion cell layer and lamina cribrosa depth may be a guide for early diagnosis. In this study, lamina cribrosa depth difference is more significant in the glaucoma suspect group so this parameter can be used in early diagnosis.

Anahtar Kelimeler

Ganglion cell complex thickness; glaucoma suspect; lamina cribrosa depth; optical coherence tomography

Glokom erken tanısında lamina kribroza derinliği ve ganglion hücre kompleks kalınlığı ölçümlerinin değerlendirilmesi

Öz

Amaç: Glokom şüphesi ile takip edilen hastaların erken tanı ve progresyonunda ganglion hücre kompleksi ölçümünün ve lamina cribrosa derinliği parametrelerinin kullanımının değerlendirilmesidir.
Gereç ve Yöntem: Glokom şüpheli ve kontrol grubu katılımcılarından Heidelberg Spectralis Spectral Domain Optik Koherens Tomografi ile ölçümler alındı. Her iki grupta ganglion hücre kompleksi kalınlıkları segmentasyon analizi ile lamina kribroza derinlikleri de katılımcıların optik sinir başı görüntüleri kullanılarak ölçüldü.
Bulgular: Çalışmaya 31 glokom şüpheli hasta ve 42 sağlıklı birey dahil edildi. Glokom şüpheli grupta ganglion hücre tabakası kalınlığı 11.46 , kontrol grubunda 12.19 idi. Ortalama lamina kribroza derinliği glokom şüphesi olan grupta 579.3 , kontrol grubunda 399.62  idi.
Sonuç: Optik koherens tomografi, glokom hastalarının tanı ve takibinde oftalmologlara yardımcı olur ve noninvaziv olarak ölçülen ganglion hücre tabakası ve lamina kribroza derinliği erken tanı için yol gösterici olabilir. Bu çalışmada glokom şüphesi olan grupta lamina cribrosa derinlik farkı daha belirgin olduğundan bu parametre erken tanıda kullanılabilir.

Anahtar Kelimeler

Ganglion cell complex thickness, glaucoma suspect; lamina cribrosa depth, optical coherence tomography

Kaynakça

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