Association of hematological indices with neurological symptoms in COVID 19 patients

Yıl 2022, Cilt: 47 Sayı: 2, 526 - 534, 30.06.2022

Selma Tekin Zeynep Ünlütürk Çağdaş Erdoğan Esin Avcı Tugba Sarı Secil Deniz Hülya Aybek Erhan Ugurlu Murat Seyit İsmail Hakkı Akbudak

Öz

Purpose: The aim of this study was to compare the neurological involvement in Coronavirus 19 (COVID-19) patients with laboratory findings with these cost-free, practical tests.
Materials and Methods: Of the 170 patients diagnosed COVID-19, 103 patients could be reached by phone, and neurological symptoms were recorded as three categories. Laboratory tests of the patients and 103 controls whose real-time polymerase chain reaction (RT-PCR) test negative without any chronic disease history and drug use were obtained from the hospital software.
Results: White blood cell, neutrophil, lymphocyte, eosinophil, basophil, platelet were lower, monocyte to lymphocyte ratio and platelet to lymphocyte ratio higher in patients than controls. In the group with central nervous system findings, red blood cell and hematocrit counts, in the group with peripheral nervous system findings, lymphocyte and platelet counts and with sleep disturbances and muscle pain group eosinophil counts were lower in patients than those without.
Conclusion: COVID-19 patients with neurological symptoms have some hematological abnormalities. The presence of certain hematological findings may be a clue to the emergence of neurological symptoms, and early detection and correction of these hematological abnormalities may be the solution to prevent the development of neurological symptoms in COVID-19.

Anahtar Kelimeler

COVID-19, neurological symptom, hematological parameters, neutrophil to lymphocyte ratio, monocyte to lymphocyte ratio, platelet to lymphocyte ratio

Teşekkür

We would like to thank all our healthcare professionals who have been working with all their might in the COVID-19 pandemic.

COVID 19 hastalarında hematolojik indekslerin nörolojik semptomlarla ilişkisi

Öz

Amaç: Bu çalışmada, Coronavirüs 19 (COVID-19) hastalarında nörolojik tutulumu laboratuvar bulguları ile karşılaştırmayı ve bu maliyetsiz, pratik testlerin prognozu öngörelebilirliğini değerlendirilmesi amaçlanmıştır.
Gereç ve Yöntem: COVID-19 tanısı konan 170 hastanın 103'üne telefonla ulaşılabildi ve nörolojik semptomlar üç kategoride kaydedildi. Herhangi bir kronik hastalık öyküsü ve ilaç kullanımı olmayan gerçek zamanlı polimeraz zincir reaksiyonu (RT-PCR) testi negatif olan 103 hasta ve 103 kontrolün laboratuvar testleri, hastane yazılım programından elde edildi.
Bulgular: Hastalarda kontrollere göre lökosit, nötrofil, lenfosit, eozinofil, bazofil, trombosit sayıları daha düşük, monosit/lenfosit oranı ve trombosit/lenfosit oranı daha yüksekti. Santral sinir sistemi bulguları olan grupta eritrosit ve hematokrit sayıları, periferik sinir sistemi bulguları olanlarda lenfosit ve trombosit sayıları ile uyku bozukluğu ve kas ağrısı olan grupta eozinofil sayıları olmayanlara göre daha düşüktü.
Sonuç: Nörolojik semptomları olan COVID-19 hastalarında bazı hematolojik anormallikler saptandı. Bazı hematolojik bulguların varlığı, nörolojik semptomların ortaya çıkması için bir ipucu olabilir ve bu hematolojik anormalliklerin baştan saptanıp düzeltilmesi, COVID-19'da nörolojik semptomların gelişimini engellemek açısından çözüm olabilir.

Anahtar Kelimeler

COVID-19, nörolojik semptom, hematolojik parametreler, nötrofil lenfosit oranı, monosit lenfosit oranı, platelet lenfosit oranı

Kaynakça

• 1. Hasöksüz M, Kiliç S, Saraç F. Coronaviruses and sars-cov-2. Turkish J Med Sci 2020;50(SI-1):549-556. doi:10.3906/sag-2004-127
• 2. Bostan S, Erdem R, Öztürk YE, Kılıç T, Yılmaz A. The effect of COVID-19 pandemic on the Turkish society. Electron J Gen Med. 2020;17(6). doi:10.29333/ejgm/7944
• 3. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
• 4. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol0 2020. doi:10.1001/jamaneurol.2020.1127
• 5. Nöroloji C-. Covid-19 and Neurology. 2020;(3):3-5.
• 6. Yang AP, Liu J ping, Tao W qiang, Li H ming. The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients. Int Immunopharmacol 2020;84(February):106504. doi:10.1016/j.intimp.2020.106504
• 7. Henry BM, De Oliveira MHS, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in cfile:///C:/Users/Nermine/Downloads/[14374331 - Clinical Chemistry and Laboratory Medicine (CCLM)] Hematologic, biochemical and immune biomarker ab. Clin Chem Lab Med 2020. doi:10.1515/cclm-2020-0369
• 8. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
• 9. Erratum: Covid-19 and long term conditions: What if you have cancer, diabetes, or chronic kidney disease? (BMJ (2020)368 (m1174) DOI: 10.1136/bmj.m1174). BMJ 2020;368(March):2020. doi:10.1136/bmj.m1270
• 10. Altunisik, E., Sayiner, H. S., Aksoz, S., Cil, E., Ozgenc, G. Neurological symptoms in COVID-19 patients. Bratislavske Lekarske Listy.2021; 122(1), 39-44.
• 11. Ferrari D, Motta A, Strollo M, Banfi G, Locatelli M. Routine blood tests as a potential diagnostic tool for COVID-19. Clin Chem Lab Med 2020;1-5. doi:10.1515/cclm-2020-0398
• 12. Sun S, Cai X, Wang H, et al. Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. Clin Chim Acta 2020;507(April):174-180. doi:10.1016/j.cca.2020.04.024
• 13. Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 2020;8(4):420-422. doi:10.1016/S2213-2600(20)30076-X
• 14. Xiaohong Y, Tingyuan L, Zhicheng H, et al. 从 Sars 尸体解剖发现 ， 浅析新型冠状病毒 感染疾病 的若干问题. Chinese J Pathol 2020;49(4):291-293. doi:10.3760/cma.j.cn112151
• 15. Salamanna F, Maglio M, Landini MP, Fini M. Platelet functions and activities as potential hematologic parameters related to Coronavirus Disease 2019 (Covid-19). Platelets 2020;00(00):1-6. doi:10.1080/09537104.2020.1762852
• 16. Lu G, Wang J. Dynamic changes in routine blood parameters of a severe COVID-19 case. Clin Chim Acta 2020;508(March):98-102. doi:10.1016/j.cca.2020.04.034
• 17. Vacchiano V, Riguzzi P, Volpi L, et al. Early neurological manifestations of hospitalized COVID-19 patients. 2020;30-32.
• 18. Wu Y, Xu X, Chen Z, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun 2020;(March):1-5. doi:10.1016/j.bbi.2020.03.031