A different approach to ecchymosis due to paroxetine

Year 2022, Volume: 47 Issue: 3, 1378 - 1380, 30.09.2022

Necla Keskin

https://doi.org/10.17826/cumj.1125732

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed medications and used for the treatment of depression and anxiety disorders mainly. SSRIs inhibit the serotonin transporter and lead depletion of serotonin in platelets. SSRIs in general, and paroxetine in particular, are associated with risk of bleeding. We report a case of spontaneous ecchymosis in young, healthy subject, after the use of paroxetine 20 mg / day. The paroxetine treatment was maintained and it was observed that the ecchymotic lesions were relieved. If the symptoms are mild and coagulation tests are normal in SSRI induced bleeding, it should be kept in mind that continuing the treatment with the same drug may be an option. Prospective studies are warranted in this area.

Keywords

Anxiety, paroxetine, ecchymosis

Paroksetin ile ilişkili ekimoza farklı bir yaklaşım

Abstract

Seçici serotonin gerialım inhibitörleri (SSGİ) sıklıkla reçete edilen ve başlıca depresyon ve anksiyete bozukluklarının tedavisinde kullanılan ilaçlardır. SSGİ ilaçlar serotonin taşıyıcısını inhibe ederek trombositlerdeki serotinin düzeylerinde azalmaya yol açarlar. SSGİ ilaçlar başta paroksetin olmak üzere anormal kanamalarla ilişkilendirilmiştir. Yazıda genç, sağlıklı olup, paroksetin 20 mg/gün kullanımı sonrası spontan ekimoz gelişen, tedavisine paroksetinle devam edilen ve takiplerinde ekimotik lezyonların azalarak geçtiği gözlenen bir olgu sunulmuştur. SSGİ ilaçlarla ilişkili kanama gelişmesi durumunda; belirtiler hafif ve koagülasyon testleri normalse, tedaviye aynı ilaçla devam etmenin de bir seçenek olabileceği akılda tutulmalıdır. Bu konuda geniş ölçekli izlem çalışmalarına ihtiyaç vardır.

Keywords

Anksiyete, paroksetin, ekimoz

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