Adalimumab induced severe paradoxical psoriasis in a patient with ankylosing spondylitis

Yıl 2022, Cilt: 47 Sayı: 4, 1768 - 1770, 28.12.2022

Emre Zekey Pinar Karabagli Gülcan Saylam Kurtipek

https://doi.org/10.17826/cumj.1170774

Öz

Anti-tumor necrosis factor (Anti-TNF)’s have been used frequently in rheumatology and dermatology. These drugs may couse psoriasiform lesions paradoxically. In this report, ankylosing spondylitis patient who developed severe paradoxical psoriasis while being treated with adalimumab was discussed.

Anahtar Kelimeler

Paradoxical Psoriasis, Adalimumab, Ankylosing Spondylitis

Ankilozan spondilit tanılı hastada adalimumabın tetiklediği paradoksal psoriasis

Öz

Anti-tümör nekroz faktör ajanlar (Anti-TNF) romatoloji ve dermatoloji pratiğinde sıklıkla kullanılmaktadır. Bu ilaçlar paradoksal olarak psoriaziform lezyonlara neden olabilir. Bu bildiride adalimumab tedavisi sırasında şiddetli paradoksal psoriazis gelişen bir ankilozan spondilit hastası tartışılmıştır.

Anahtar Kelimeler

Paradoksal Psoriasis, Adalimumab, Ankilozan Spondilit

Kaynakça

• 1. Conrad C, Di Domizio J, Mylonas A, Belkhodja C, Demaria O, Navarini AA, et al. TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis. 2018;9(1):1-11.
• 2. Soumelis V, Liu YJJEjoi. From plasmacytoid to dendritic cell: morphological and functional switches during plasmacytoid pre‐dendritic cell differentiation. 2006;36(9):2286-92.
• 3. Mylonas A, Conrad CJFii. Psoriasis: Classical vs. paradoxical. The Yin-Yang of TNF and type I interferon. 2018;9:2746.
• 4. Cleynen I, Vermeire SJNrG, hepatology. Paradoxical inflammation induced by anti-TNF agents in patients with IBD. 2012;9(9):496-503.
• 5. Brown G, Wang E, Huynh M, Wehner M, Matro R, Linos E, et al. Tumor necrosis factor-α inhibitor-induced psoriasis: systematic review of clinical features, histopathological findings, and management experience. 2017;76(2):334-41.
• 6. Nestle FO, Conrad C, Tun-Kyi A, Homey B, Gombert M, Boyman O, et al. Plasmacytoid predendritic cells initiate psoriasis through interferon-α production. 2005;202(1):135-43.
• 7. Ko JM, Gottlieb AB, Kerbleski JFJJoDT. Induction and exacerbation of psoriasis with TNF-blockade therapy: a review and analysis of 127 cases. 2009;20(2):100-8.
• 8. Benzaquen M, Flachaire B, Rouby F, Berbis P, Guis SJRI. Paradoxical pustular psoriasis induced by ustekinumab in a patient with Crohn’s disease-associated spondyloarthropathy. 2018;38(7):1297-9.
• 9. Puig L, Morales-Múnera CE, López-Ferrer A, Geli CJD. Ustekinumab treatment of TNF antagonist-induced paradoxical psoriasis flare in a patient with psoriatic arthritis: case report and review. 2012;225(1):14-7.
• 10. Li SJ, Perez-Chada LM, Merola JFJJop, arthritis p. TNF inhibitor-induced psoriasis: proposed algorithm for treatment and management. 2019;4(2):70-80.