Depresyon ve anksiyetede Ashwagandha bitkisinin klinik uygulamaları

Yıl 2024, Cilt: 49 Sayı: 3, 818 - 833, 30.09.2024

Havanur Güllü , Olcay Kıroğlu

https://doi.org/10.17826/cumj.1460207

Öz

Ashwagandha, geleneksel Hint tıbbında uzun süredir kullanılan adaptogenik bir bitkidir ve son yıllarda modern tıpta dikkat çekmektedir. Ashwagandha, adaptogen özellikleri sayesinde vücutta dengeyi sağlama yeteneği ile bilinmektedir. Anksiyete ve depresyon, modern toplumda giderek artan bir halk sağlığı sorunudur. Ashwagandha'nın içerdiği biyoaktif bileşenler, özellikle withanolid, sinir sistemini etkileyen bir dizi biyolojik mekanizma üzerinden anksiyete ve depresyonun hafifletilmesine katkıda bulunabilir. Bu durum, nörotransmitterlerin düzenlenmesi, anti-inflamatuar etkiler ve stresle başa çıkma mekanizmalarını destekleme yoluyla gerçekleşebilir. Ashwagandha'nın, geleneksel antidepresan ve anksiyolitik ilaçlara kıyasla daha az yan etkiye neden olması ve doğal bir adaptogen olarak geniş bir etki mekanizmasına sahip olması, gelecekteki potansiyel terapötik seçenekleri açısından önemli bir avantaj sunmaktadır. Literatürdeki birçok araştırma, Ashwagandha'nın bu alanlarda potansiyel bir doğal yardımcı olarak rol oynayabileceğini öne sürmektedir. Ancak, bu potansiyeli tam anlamıyla değerlendirebilmek için daha fazla klinik çalışma ve uzun vadeli etki analizlerine ihtiyaç duyulmaktadır. Bu derleme, Ashwagandha'nın anksiyete ve depresyonla mücadeledeki etkinliği konusunda mevcut literatürü değerlendirerek, gelecekteki araştırmalara yönelik bir temel oluşturmayı amaçlamaktadır.

Anahtar Kelimeler

Anksiyete, depresyon, Ashwagandha

Etik Beyan

ETİK KURUL BELGESİ GEREK OLMADIĞI BEYAN EDİLMİŞTİR

Clinical applications of Ashwagandha plant in depression and anxiety

Öz

Ashwagandha is an adaptogenic herb that has been long used in traditional Indian medicine and has garnered attention in modern medicine in recent years. Known for its ability to restore balance in the body due to its adaptogenic properties, Ashwagandha is believed to offer potential benefits in addressing anxiety and depression, which are growing public health concerns in modern society. The bioactive components found in Ashwagandha, particularly withanolides, may contribute to reducing symptoms of anxiety and depression through various biological mechanisms that affect the nervous system. This can involve the regulation of neurotransmitters, anti-inflammatory effects, and support for stress coping mechanisms. The fact that Ashwagandha tends to cause fewer side effects compared to conventional antidepressants and anxiolytic drugs, along with its broad mechanism of action as a natural adaptogen, presents a significant advantage in terms of potential future therapeutic options. Many studies in the literature suggest that Ashwagandha could serve as a natural adjunct in these areas. However, more clinical trials and long-term effect analyses are necessary to fully evaluate this potential. This review aims to lay the groundwork for future research by assessing current literature on the effectiveness of Ashwagandha in addressing anxiety and depression.

Anahtar Kelimeler

Anxiety, depression, Ashwagandha

Kaynakça

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