Klinik olarak stabil multipl sklerozda radyolojik hastalık aktivitesinin bir göstergesi olarak nötrofil/lenfosit oranı

Year 2024, Volume: 49 Issue: 3, 721 - 727, 30.09.2024

Esra Tekin Taşkıran , Bilgin Öztürk

https://doi.org/10.17826/cumj.1477602

Abstract

Amaç: Multipl Skleroz (MS), merkezi sinir sisteminin demiyelinizan bir hastalığıdır ve gençlerde engelliliğe neden olan en yaygın nörolojik bozukluktur. Hem tanı hem de takip için hassas ve spesifik bir belirteç yoktur. Nötrofil/lenfosit oranı kolay uygulanabilir bir yöntemdir ve bu çalışmada MS'de izole radyolojik aktivite varlığında bu orandaki değişiklikleri gözlemlemeyi amaçladık.
Gereç ve Yöntem: Klinik atak veya nörolojik progresyonu olmayan ve sadece radyolojik aktivitesi olan 20 aktif MS hastasını, yaş ve cinsiyet açısından eşleştirilmiş 20 klinik ve radyolojik olarak stabil MS hastasıyla NLR açısından karşılaştırdık.
Bulgular: Radyolojik olarak aktif hasta grubunda ortalama NLR değeri 2.22±0.87 (Min 1.08-Maks 4.28), kontrol grubunda ise ortalama NLR değeri 2.31±1.37 (Min 0.96-Maks 5.92) olarak bulundu. Sadece radyolojik aktivitesi olan hastalardaki NLR değerlerinin hem klinik hem de radyolojik stabilitesi olan hastalardaki NLR değerlerinden anlamlı derecede farklı olmadığını gözlemledik.
Sonuç: MS'in tanı ve takibinde belirteç çalışmaları hızla devam etmektedir. NLR gibi basit, kolay uygulanabilir, non-invaziv, ucuz yöntemlerin MS hastalık aktivitesi ile ilişkisini ortaya koymak için çok daha geniş kohortu içeren prospektif çalışmalar yol gösterici olabilir.

Keywords

Nötrofil lenfosit oranı, multipl skleroz, relaps, hastalık aktivitesi

Supporting Institution

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Thanks

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Neutrophil/lymphocyte ratio as an indicator of radiological disease activity in clinically stable multiple sclerosis

Abstract

Purpose: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and the most common neurological disorder causing disability in young people. There is no sensitive and specific marker for both diagnosis and follow-up. Neutrophil to lymphocyte ratio is an easily applicable method and in this study we aimed to observe the changes in this ratio in the presence of isolated radiologic activity in MS.
Materials and Methods: We compared 20 MS active patients with no clinical attack or neurologic progression and only radiologic activity with 20 age- and sex-matched clinically and radiologically stable MS patients in terms of NLR.
Results: Mean NLR value was 2.22±0.87 in radiologically active patient group (Min 1.08-Max 4.28) and mean NLR value was 2.31±1.37 in control group (Min 0.96-Max 5.92). We observed that NLR values in patients with radiologic activity only were not significantly different from NLR values in patients with both clinical and radiologic stability.
Conclusion: Marker studies in the diagnosis and follow-up of MS continue rapidly. Prospective studies involving a much larger cohort may be instructive in order to demonstrate the association of simple, easily applicable, non-invasive, inexpensive methods such as NLR with MS disease activity.

Keywords

Neutrophil, lymphocyte, ratio, Multiple Sclerosis, Relapse, Disease Activity

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