Parkinson hastalığında motor olmayan semptomlar ile nötrofil-lenfosit oranı arasındaki ilişki

Year 2024, Volume: 49 Issue: 4, 916 - 924, 30.12.2024

Dilek İşcan , Gürkan Demirtaş , Aslı Demirtaş

https://doi.org/10.17826/cumj.1503745

Abstract

Amaç: Bu çalışmanın amacı bir inflamasyon belirteci olan nötrofil/lenfosit oranı (NLR) ile Parkinson Hastalığında (PH) yorgunluk, uyku ve yaşam kalitesi arasındaki ilişkiyi araştırmaktır.
Gereç ve Yöntem: Araştırma örneklemimiz PH tanısı konmuş toplam 60 hastadan (17 kadın, 43 erkek) oluşmaktadır. Yorgunluk Parkinson Hastalığı Yorgunluk Ölçeği (PFS-16), uyku kalitesi Parkinson Hastalığı Uyku Ölçeği (PDSS) ve yaşam kalitesi Parkinson Hastalığı Anketi-8 (PDQ-8) ile değerlendirilmiştir. Nötrofil ve lenfosit sayıları hemogram testi ile elde edilmiş ve oranlanarak hesaplanmıştır.
Bulgular: PH hastalarında yorgunluk ile uyku kalitesi arasında anlamlı, negatif ve orta düzeyde; yaşam kalitesi, motor derecelendirme ve hastalık evrelemesi arasında pozitif ve orta düzeyde; uyku kalitesi ile yaşam kalitesi arasında negatif ve orta düzeyde; uyku kalitesi ile motor derecelendirme ve hastalık evrelemesi arasında negatif ve zayıf düzeyde; yaşam kalitesi ile motor derecelendirme ve hastalık evrelemesi arasında pozitif ve zayıf düzeyde korelasyon bulunmuştur. Non-motor semptomlar ile NLR arasında ilişki bulunmamıştır.
Sonuç: NLR gibi basit, ucuz bir biyobelirteçin PH takibi bağlamında potansiyel klinik avantajlarını ve bu tür biyobelirteçlerin hastalık semptomları üzerindeki etkisini belirlemek için çok daha büyük bir kohort veya vaka-kontrol içeren daha ileri prospektif çalışmalar yol gösterici olabilir.

Keywords

Parkinson Hastalığı, yorgunluk, uyku bozuklukları, yaşam kalitesi, nötrofil/lenfosit oranı

Ethical Statement

Niğde Ömer Halisdemir University Faculty of Medicine Non-Interventional Clinical Research Ethics Committee approval has been granted from our institution with protocol number Meeting/Decision No: 2022-107

Supporting Institution

yok

Project Number

Clinicaltrials: NCT05687799

Thanks

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Relationship between nonmotor symptoms and neutrophil-to-lymphocyte ratio in Parkinson’s disease

Abstract

Purpose: The aim of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), an inflammation marker, and nonmotor symptoms, such as fatigue, sleep disturbances, and overall quality of life, in Parkinson’s disease (PD).
Materials and Methods: This study included 60 patients diagnosed with PD (17 female and 43 male). Fatigue was assessed using the Parkinson’s Disease Fatigue Scale (PFS-16), sleep quality using the Parkinson’s Disease Sleep Scale (PDSS), and quality of life using the Parkinson’s Disease Questionnaire-8 (PDQ-8). Neutrophil and lymphocyte counts were extracted from the complete blood count results, and the NLR was calculated.
Results: A moderate, negative correlation was observed between fatigue and sleep quality; a moderate, positive correlation was observed between quality of life, motor rating, and disease staging; a moderate, negative correlation was observed between sleep quality and quality of life; a weak, negative correlation was observed between sleep quality, motor rating, and disease staging; and a weak, positive correlation was found between quality of life, motor rating, and disease staging. No significant relationship was observed between NLR and nonmotor symptoms in PD.
Conclusion: Further prospective studies with larger samples or case–control designs are warranted to explore the potential clinical utility of a simple, cost-effective biomarker, such as NLR, in assessing PD symptoms and disease progression.

Keywords

Parkinson’s Disease, fatigue, sleep disorders, quality of life, neutrophil-to-lymphocyte ratio.

Project Number

Clinicaltrials: NCT05687799

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