Markers of inflammation in patients with generalized anxiety disorder

Year 2024, Volume: 49 Issue: 4, 908 - 915, 30.12.2024

Sevler Yıldız , Aslı Kazğan Kılıçaslan , Burcu Sırlıer Emir , Muhammed Fatih Tabara , Osman Kurt , Şeyma Sehlikoğlu , Kerim Uğur

https://doi.org/10.17826/cumj.1510275

Abstract

Purpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation index, neutrophil/HDL, lymphocyte/HDL, platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety disorder (GAD).
Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lipoprotein (HDL-c) levels, neutrophil, monocyte, lymphocyte, and platelet counts; systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), neutrophil/high-density lipoprotein ratio (NHR), lymphocyte/high-density lipoprotein ratio (LHR), monocyte/high-density lipoprotein ratio (MHR), and platelet/high-density lipoprotein ratio (PHR) were calculated.
Results: The median age of the case group was 35.50 (interquartile range: 28.00-44.00), while the median age of the control group was 35.00 (interquartile range: 28.00-44.00). In the GAD group, neutrophils, monocytes, SII, SIRI, NHR, LHR, MHR, and PHR were significantly higher, while platelets and HDL were significantly lower.
Conclusions: This study highlights that elevated systemic inflammation markers, such as SII and SIRI, along with altered HDL ratios, may be associated with GAD. The findings support the hypothesis that inflammation plays a role in the etiopathogenesis of GAD, potentially contributing to both diagnosis and management.

Keywords

Generalized anxiety disorder, SIRI, SII, NHR, LHR, MHR, PHR, inflammation

Yaygın anksiyete bozukluğu tanılı hastalarda inflamasyon belirteçleri

Abstract

Amaç: Bu çalışmada yaygın anksiyete bozukluğu (YAB) hastalarında inflamasyon belirteçleri olarak kullanılan sistemik immün cevap indeksi, sistemik immün inflamasyon indeksi, nötrofil/HDL, lenfosit/HDL, platelet/HDL ve monosit/HDL oranını incelemeyi amaçlanmıştır.
Gereç ve Yöntem: Bu çalışmaya 432 sağlıklı kontrol ve 432 YAB tanılı hasta olmak üzere toplam 864 katılımcı dahil edildi. Yüksek yoğunluklu lipoprotein (HDL-c) seviyeleri, nötrofil, monosit, lenfosit ve trombosit sayıları; sistemik inflamatuar yanıt indeksi (SIRI), sistemik immün-inflamatuar indeks (SII), nötrofil/yüksek yoğunluklu lipoprotein oranı (NHR), lenfosit/yüksek yoğunluklu lipoprotein oranı (LHR), monosit/yüksek yoğunluklu lipoprotein oranı (MHR), trombosit/yüksek yoğunluklu lipoprotein oranı (PHR) hesaplandı.
Bulgular: Vaka grubunun ortanca yaşı 35.50 (çeyrekler arası aralık: 28.00-44.00), kontrol grubunun ortanca yaşı ise 35.00 (çeyrekler arası aralık: 28.00-44.00) idi. GAD grubunda nötrofil, monosit, SII, SIRI, NHR, LHR, MHR ve PHR değeri kontrol grubundan anlamlı şekilde yüksek; trombosit ve HDL değeri ise anlamlı şekilde düşük bulunmuştur.
Sonuç: Bu çalışma, SII ve SIRI gibi yüksek sistemik inflamasyon belirteçlerinin, değişmiş HDL oranları ile birlikte, YAB ile ilişkili olabileceğini vurgulamaktadır. Bulgular, inflamasyonun YAB'nin etiyopatogenezinde rol oynadığı hipotezini desteklemekte ve potansiyel olarak hem tanıya hem de tedaviye katkıda bulunmaktadır.

Keywords

Yaygın anksiyete bozukluğu, SIRI, SII, NHR, LHR, MHR, PHR, inflamasyon

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