Use microRNA-200c in Endometrial Cancer Treatment with Bioinformatics Tools

Yıl 2015, Cilt: 36 Sayı: 3, 2317 - 2324, 13.05.2015

Ali Saları Ghasem Jamalı Mansour Ebrahımı

Öz

Abstract. Endometrial cancer has two types. In this study we assessed the type 2 by microRNA-200c to find differential genes between the two treatment and control groups and then to find the genes candidate (candidate genes) for microRNA treatment instead of surgery which is the most fundamental treatment in this cancer. By some software’s as GEO2R, 85 types (kinds) of genes with differential expression from control and treatment groups were calculated. Also by DAVID tools, the candidates’ genes function was extracted. For the first time the genes obtained by microarray data were introduced as candidates for diagnose and treatment of Endometrial cancer cells. The most important genes from the 12 candidates up regulated genes. The 4 genes namely PLAC8, AKR1D1, ANXA3, ESYT2 and from the 9 down regulated candidate genes by miR-200c, 3 genes SLC17A3,THEMIS2, L3HYPDH were reported for the first time in this study. The two above mentioned finding are reported for the first .

Anahtar Kelimeler

Treatment, miR-200c, endometrial cancer