In vitro Cytogenotoxic Effects of a Coumarin-Selenophene Hybrid Compound

Abstract

This study was carried out to reveal the in vitro cytogenotoxic effect of 2-amino-5-(6-bromo-2-oxo-2H-chromen-3-yl) selenophene-3-carbonitrile (6-BrCoumSel or CoumSel), a newly synthesized coumarin-selenophene hybrid compound. Coumarin (2H-chromen-2-one), one of the main components of the test substance hybrid molecule (CoumSel), is an aromatic organic chemical compound with the formula C9H6O2. Pharmacologically, coumarin belongs to the flavonoid group of chemicals. The other component, selenophene, has the formula C4H4Se and is an unsaturated organic compound containing a five-membered ring containing selenium in its structure. It is a colorless liquid and is one of the most common selenium heterocycles. It was found that in human lymphocytes cultured in vitro, the hybrid CoumSel compound increased the frequency of chromosome abnormalities (CA) and micronuclei (MN), especially at high concentrations, compared to the untreated group (0 µg/ml). The potential of CoumSel as an antiproliferative drug with its current properties should not be ignored.

Keywords

• Coumarin-selenophene hybrid compound
• in vitro human lymphocyte
• chromosome aberration

Project Number

FYL-2020-12800

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