BIOAPYGIN HERBAL OINTMENT AND PESSARIES COMPARED TO ACIDOSALUS PESSARIES AND VAGINAL PROBIOTIC IN THE TREATMENT OF VULVO-VAGINAL DISORDERS

Year 2019, , 11 - 22, 29.07.2019

Višnja Oreščanin , štefica Findri Guštek

https://doi.org/10.38093/cupmap.552083

Abstract

Objective / Purpose: The objective of the study was
assessment of the clinical efficacy and safety of Bioapigyn^Ò vaginal ointment and pessaries
compared to Acidosalus^Ò pessaries and vaginal probiotic in
alleviating vulvo-vaginal disorders.

Materials and
methods: 124 females
were randomly selected into four groups (each of 31 participants) and treated
once a day for ten days with: A) Bioapigyn^Ò vaginal pessaries (one pessary per
day); B) 2.5 mL of Bioapygin^Ò vaginal ointment; C) Acidosalus^Ò vaginal pessaries (one pessary per
day); D) 2.5 mL of Acidosalus^Ò vaginal probiotic. All the patients were subjected to
gynecological examination, measurement of vaginal pH, Pap test, native and KOH
test, self-assessment and clinical assessment of the symptoms at baseline and
following the therapy.

Results: Following the treatment with Bioapigin^Ò vaginal ointment, Bioapigyn^Ò
pessaries, Acidosalus^Ò pessaries, Acidosalus^Ò vaginal
probiotic the total score of vulvo-vaginal disorders decreased for 85.2%,
88.9%, 82.7% and 78%, respectively and vaginal pH decreased between 9.1% and 14.3%.
Native test showed normalization of the vaginal flora following the treatment
with all four products with no significant difference among the products.

Conclusion/Discussion:
Both Bioapigyn^Ò and
Acidosalus^Ò products
were highly efficient in alleviation of vulvo-vaginal disorders. The products
created unfavorable conditions for pathogenic growth through the lowering of
vaginal pH value, promoting the growth of lactobacilli, creating the environment
with low water activity and creating a protective layer on the damaged mucosa
that creates a physical barrier to the entrance of the pathogens into the cells
and enables the recovery of the vaginal mucosa.

Keywords

Bioapygin, Acidosalus, vulvo-vaginal disorders, vaginal pH, herbal macerates

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