The Efficiency of Bioapifit® Wound Care Ointment in the Treatment of Diabetic Foot Ulcers

Abstract

Objective/Purpose: The objective of this study was efficacy and safety assessment of Bioapifit® wound care ointment consisted of honey, Cera flava, glycerin, the oil macerates of astringent and soothing herbs  combined with essential oils for the treatment of diabetic neuropathic foot ulcers of grade II. Materials and methods: 50 patients with Wagner grade II diabetic foot ulcers were randomized into experimental and control group (25 patients each). The experimental group was treated 28 days with Bioapifit® wound care ointment applied on the wound after cleaning with povidone iodine once a day and covered with sterile gauze and bandage during the whole course of the study. The control group wounds  were cleaned with povidone iodine once a day and covered with sterile gauze and bandage during the whole course of the study without further treatment. The ulcers surface area was measured at baseline and after 14 and 28 days of the treatment. Results: In the end of the treatment the mean values and standard deviation of the surface area in the experimental group dropped from 8.27±6.1 cm² to 0.74±0.21 cm² for males and from 9.01±5.9 cm² to 0.81±0.11 cm² for females. Slight, insignificant decrease was also observed in the control population (up to 25%). No side-effects were observed during the course of the study. Conclusion/Discussion: Four weeks treatment with Bioapifit® wound care ointment resulted in complete wound closure in 84% of the patients and 91% reduction in the wound surface area in the rest of them.

Keywords

• diabetic foot ulcers,honey,beeswax,herbal macerate,essential oils

References

1. 1. Abascal, K., Yarnell, E., 2005. Botanical Treatments for Hemorrhoids. Alternative and Complementary Therapies, 11(6), 285-289.
2. 2. Alam, F., Islam, M.A., Gan, S.H., Khalil, M.I., 2014. Honey: a potential therapeutic agent for managing diabetic wounds. Evidence-Based Complementary Alternative Medicine, Article ID 169130. doi:10.1155/2014/169130.
3. 3. Cooper, R., 2017. The use of honey in diabetic foot ulcers. The Diabetic Foot Journal 20 (3), 154 – 159.
4. 4. Doupis, J., Veves, A., 2008, Classification, diagnosis, and treatment of diabetic foot ulcers. Wounds, 20, 117–126.
5. 5. Eddy, J.J., Gideonsen, M.D., Mack, G.P., 2008. Practical considerations of using topical honey for neuropathic diabetic foot ulcers: a review. Wisconsin medical journal, 107(4),187-190.
6. 6. Gethin, G.T., Cowman, S., Conroy, R.M., 2008. The impact of Manuka honey dressings on the surface pH of chronic wounds. International Wound Journal, 5(2), 185-194.
7. 7. Imran, M., Hussain, M.B., Baig, M., 2015. A randomized, controlled clinical trial of honey-impregnated dressing for treating diabetic foot ulcer. Journal of College of Physicians and Surgeons Pakistan, 25(10), 721–725.
8. 8. Kamaratos, A.V., Tzirogiannis, K.N., Iraklianou, S.A., Panoutsopoulos, G.I., Kanellos, I.E., Melidonis, A.I., 2014. Manuka honey-impregnated dressings in the treatment of neuropathic diabetic foot ulcers. International Wound Journal, 11(3), 259-263.

9. 9. Mohamed, H., Abu Salma, M., Al Lenjawi, B., Abdi, S., Gouda, Z., Barakat, N., Elmahdi, H., Abraham, S., Hamza, A.H., Al Khozaei, D., Al Majid, S., Al Majid, H., Abdini, J., Al Jaber, M., Al Masseh, F., Al Ali, A.A., 2015. The Efficacy and Safety of Natural Honey on the Healing of Foot Ulcers: A Case Series. Wounds, 27(4), 103-114.
10. 10. Odukoya, O.A., Ilori, O.O., Sofidiya, M.O., 2007. Astringent herbs as vasoconstrictors in haemorrhoid therapy. Planta Medica, 73, 231-231. 11. Oreščanin, V., 2016. Treatment of pressure ulcers with Bioapifit® wound healing herbal ointment - a preliminary study. IJRDO-Journal of biological science, 2(10), 1-15.
11. 12. Tsang, K-K., Wai-Yung Kwong, E., Shing-Shun To, T., Wai-Yee Chung, J., Kwok-Shing Wong, T., 2017. A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer. Evidence-Based Complementary and Alternative Medicine, Article ID 5294890