Febril Nöbet Tiplerinde Hemogram Parametrelerinin Karşılaştırılması

Year 2020, , 1 - 6, 30.04.2020

Zühal Örnek , Hakan Kardeş , İbrahim Etem Pişkin Mustafa Çalık

https://doi.org/10.18678/dtfd.628239

Cited By: 4

Abstract

Amaç: Febril nöbetler (FN) çocukluk çağında en sık görülen nörolojik aciller arasındadır ve klinik olarak basit febril nöbetler (BFN) ve komplike febril nöbetler (KFN) olmak üzere iki tipte sınıflandırılır. FN tiplerinin ayrımı, farklı morbidite ve mortalite riskleriyle ilişkili olması ve her nöbetin klinik özelliklerine dayanması nedeniyle önemlidir, ancak şu anda bu farklılaşmaya yol gösterecek laboratuvar testi bulunmamaktadır. Bu çalışmada FN tipleri ve hemogram parametreleri arasındaki ilişki incelenmiş ve bu parametrelerin ayırıcı tanıda potansiyel kullanımı araştırılmıştır.
Gereç ve Yöntemler: Bu retrospektif çalışmaya, FN kriterlerine uyan, ilk defa FN geçiren ve hemogram sonuçlarına ulaşılabilen toplam 133 hasta dahil edildi. Tanıyı doğrulamak için Amerikan Pediatri Akademisi kriterleri kullanıldı. Hastalar BFN ve KFN olmak üzere iki gruba ayrıldı.
Bulgular: Her iki grup arasında hemoglobin (Hb), hematokrit (HCT), ortalama trombosit hacmi (MPV), nötrofil lenfosit oranı (NLO) ve trombosit lenfosit oranı (TLO) değerleri anlamlı şekilde farklıyken (sırasıyla p<0,001; p=0,002; p=0,033; p<0,001; p<0,001) diğer tam kan sayımı parametrelerinde ise anlamlı bir farklılık yoktu. Ayrıca, KFN grubunda MPV, BFN grubuna göre anlamlı derecede yüksekti.
Sonuç: Bu çalışma çocuklarda hemogram parametreleri ile FN tipleri arasındaki potansiyel ilişkiyi araştıran az sayıdaki çalışmadan biridir. Hemoglobin, MPV, NLO ve TLO’nun kesin bir ayrım sağlamasa da özellikle nöbet hikayesi net olmayan hastalarda klinisyenlere FN tiplerinin ayırt edilmesinde yardımcı olacağını düşünmekteyiz

Keywords

Febril nöbetler, komplike, basit, hemogram

Comparison of Hemogram Parameters in Febrile Seizures Types

Abstract

Aim: Febrile seizures (FS) are among the most common neurological emergencies during childhood and clinically classified into two types, being simple febrile seizures (SFS) and complicated febrile seizures (CFS). The differentiation between FS types is important, in that they are associated with different morbidity and mortality risks and it is based on the clinical characteristics of each seizure, however there is currently no laboratory test that can guide this differentiation. In this study, the relationship between FS types and hemogram parameters was evaluated and potential use of these parameters in differential diagnosis was investigated.
Material and Methods: This retrospective study included a total of 133 patients whose first FS met the criteria of an FS, and whose hemogram results were available. The American Academy of Pediatrics criteria were used to confirm the diagnosis. The patients were divided into two groups as SFS and CFS.
Results: Hemoglobin (Hb), hematocrit (HCT), mean platelet volume (MPV), neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) differed significantly between two groups (p<0.001, p=0.002, p=0.033, p<0.001, p<0.001, respectively), while no significant difference was identified in total blood count parameters. Moreover, MPV was significantly higher in CFS group than in SFS group.
Conclusion: This is one of the few studies investigating the potential relationship between hemogram parameters and FS types in children. We believe that, although they do not ensure a clear differentiation, Hb, MPV, NLR and PLR may be useful to clinicians in differentiating between FS types, particularly in patients with an unclear seizure history

Keywords

Febrile seizures, simple, complicated, hemogram

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