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Pregnancy and Epılepsy

Yıl 2016, Cilt: 18 Sayı: 1, 35 - 41, 01.03.2016

Öz

Epilepsy is one of the chronic diseases that has been based on before three thousand years ofthe Assyrian-Babylonian, Chinese and Indian sources, is still important and has been had adifferent significance for women. Though that pregnancy itself is a complicated process, one ofthe important periods of women's life, the process can be more emphasized for women withepilepsy. Epilepsy, the adverse effects of the seizures and anti-epileptic drugs on the mother andfetus has been investigated by lots of researchers. This periods contains; the doctor supervisionbefore planning pregnancy, usage of folic acid, a seizure-free period, the selection of likely toless teratogenic anti-epileptic drugs. Epilepsy and pregnancy period has been explained in thisreview

Kaynakça

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GEBELİK ve EPİLEPSİ

Yıl 2016, Cilt: 18 Sayı: 1, 35 - 41, 01.03.2016

Öz

Kadınlar için ayrı bir önem taşıyan ve kronik hastalıklardan biri olan epilepsi, geçmişi üç binyıl öncesi Asur-Babil yazmaları ile Çin ve Hint kaynaklarına dayanmaktadır. Gebelik komplikebir süreçtir. Kadın hayatının vazgeçilmez periyotlarından biri olan bu süreç, epilepsili kadınlariçin ayrıca bir önem kazanmaktadır. Epilepsinin, geçirilen nöbetlerin ve anti epileptik ilaçlarınanne ve fetüs üzerindeki olumsuz etkilerini ortaya koyan pek çok çalışma yapılmıştır. Budönem, doktor danışmanlığında planlı gebelik, folik asit kullanımını, nöbetsiz bir süreci veteratojenik etkisi daha az olan bir antiepileptik ilacın seçimini ihtiva etmektedir. Sunulanderleme ile gebelik süreci ve epilepsi hakkında bilgi verilmeye çalışıldı

Kaynakça

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  • Morrow JI, Hunt SJ, Russell AJ, Smithson WH, Parsons L, Robertson I, Waddell R, Irwin B, Morrison PJ, Craig JJ. Folic acid and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J. Neurol. Neurosurg. Psychiatry. 2009; 80(5): 506–11.
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  • Lindhout D. Antiepileptic drugs during pregnancy and cognitive outcomes. Lancet Neurol. 2013; 12(3): 219-20.
  • Nulman I. Carbamazepine in pregnancy. BMJ. 2010; 341: 6582.
  • Hill DS, Wlodarczyk BJ, Palacios AM, Finnell RH. Teratogenic effects of antiepileptic drugs. Expert Rev. Neurother. 2010; 10(6): 943–59.
  • Beghi E, Annegers JF and Collaborative Group for the Pregnancy. Pregnancy Registries in Epilepsy. Epilepsia. 2002; 42(11): 1422–25.
  • Banach R, Boskovic R, Einarson T, Koren G. Long-term developmental outcome of children of women with epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies. Drug Saf. 2010; 33(1): 73-9.
  • Nadebaum C, Anderson V, Vajda F, Reutens D, Barton S, Wood A.The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy. J. Int. Neuropsychol. Soc. 2011; 17(1): 133-42.
  • Kalinin VV, Polyanskiy DA. Gender diffrences in risk factrors of suicidal behaviour in epilepsy. Epilepsy Behav. 2005; 6(3): 424-9.
  • Babayigit A, Dirik E, Bober E, Cakmakcı H. Adverse effects of antiepileptic drugs on bone mineral density. Pediatr. Neurol. 2006; 35(3): 177-81.
  • Chmielewska B, Lis K, Rejdak K, Balcerzak M, Steinborn B. Pattern of adverse events of antiepileptic drugs: results of the aESCAPE study in Poland. Arch. Med. Sci. 2013; 9(5): 858- 64.
  • Hesdorffer DC, Kanner AM: The FDA alert on suicidality and antiepileptic drugs: fire or false alarm? Epilepsia 2009; 50: 978-86.
  • Sethi NK, Wasterlain A,Harden CL. Pregnancy and epilepsy. The journal of family practice. 2010; 59(12): 675-9.
  • Adedinsewo DA, Thurman DJ, Luo YH, Williamson RS, Odewole OA, Oakley GP Jr. Valproate prescriptions for nonepilepsy disorders in reproductive-age women. Birth Defects Res A Clin Mol Teratol. 2013; 97(6): 403-8.
  • Meador K, Reynolds MW, Crean S, Fahrbach K, Probst C.Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res. 2008; 81(1): 1-13.
  • Semczuk-Sikora A, Czuczwar S, Semczuk A, Kwaśniewska A, Semczuk M. Valproik acid transfer across human plecantal cotyledon during dual perfusion in vitro. Ann. Agric. Environ. Med. 2010; 17(1): 153–7.
  • Charlton R, Weil J, Cunnington M, Ray S, Vries C. Comparing the General Practice Research Database and the UK Epilepsy and Pregnancy Register as Tools for Postmarketing Teratogen Surveillance: Anticonvulsants and the Risk of Major Congenital Malformations. Drug Safety. 2011; 34(2): 157-71.
  • Meador KJ, Baker GA, Browning N, Smith JC, Cantrell DTC, Chen M, Kalyjian LA, Kanner A, Liporace JD, Pennell PG, Privitera M, Loring DW. Coginitif function at 3 years after fetal exposure to antiepiletic drugs. J. N. Eng. Med. 2009; 360(16): 1597-1605.
  • Filgueiras CC, Pohl-Guimarães F, Krahe TE, Medina AE. Sodium valproate exposure during the brain growth spurt transiently impairs spatial learning in prepubertal rats. Pharmacol. Biochem. Behav. 2013; 103(3): 684-91.
  • Vajda F, Lander C, O’Brien T. Australian pregnanacy registry of women taking antiepileptic drugs. Epilepsia. 2004; 45(11): 1466.
  • Ettinger AB, Argoff CE.Use of antiepileptic drugs for nonepileptic conditions: psychiatric disorders and chronic pain. Neurotherapeutics. 2007; 4(1): 75-83.
  • Jentink J, Dolk HD, Loane MA, Morris JK, Wellesley D, Garne E. Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case-control study. BMJ. 2010; 341: 6581.
  • Lorente CA, Tassinari MS, Keith DA. The effects of phenytoin on rat development: an animal model system for fetal hydantoin syndrome. Teratology. 1981; 24(2): 169-80.
  • Puho EH, Szunyogh M, Metneki J. Drug treatment during preganancy and isolated orofacial clefts in Hungary. J. Cleft Palate Craniofac. 2007; 44: 194-02.
  • Hernández-Díaz S, Smith CR, Shen A, Mittendorf R, Hauser WA, Yerby M, Holmes LB; North American AED Pregnancy Registry; North American AED Pregnancy Registry. Comparative safety of antiepileptic drugs during pregnancy. Neurology. 2012; 78(21): 1692-9.
  • Cohen MJ, Meador KJ, Browning N, May R, Baker GA, Clayton-Smith J, Kalayjian LA, Kanner A, Liporace JD, Pennell PB, Privitera M, Loring DW; NEAD study group. Fetal antiepileptic drug exposure: Adaptive and emotional/behavioral functioning at age 6years. Epilepsy Behav. 2013; 29(2): 308-15.
  • Sabers A. Algorithm for lamotrigine dose adjustment before, during, and after pregnancy. Acta Neurol. Scand. 2012; 126(1): e1-4.
  • Clark CT, Klein AM, Perel JM, Helsel J, Wisner KL. Lamotrigine dosing for pregnant patients with bipolar disorder. Am J Psychiatry. 2013; 170(11):1240-7.
  • Moore JL, Aggarwal P. Lamotrigine use in pregnancy. Expert Opin. Pharmacother. 2012; 13(8): 1213-6.
  • Vajda FJ, Graham J, Roten A, Lander CM, O'Brien TJ, Eadie M.Teratogenicity of the newer antiepileptic drugs--the Australian experience. J. Clin. Neurosci. 2012; 19(1): 57-9.
  • Dolk H, van den Berg Lde J, Loane M, Wang H, Morris J. Newer anticonvulsants: lamotrigine. Birth Defects Res. A . Mol. Teratol. 2012; 94(11): 959.
  • Tecoma ES. Oxcarbazepine. Epilepsia. 1999; 40 (5): 37–46.
  • Meischenguiser R, Giano CHD, Ferrarob SM. Oxcarbazepine in pregnancy: clinical experience in Argentina. Epilepsy & Behavior. 2004: 5(2): 163-7.
  • Montouris G. Safety of the newer antiepileptic drug oxcarbazepine during pregnancy. Curr. Med. Res. Opin. 2005; 21(5): 693-701.
  • Nielsen DM, Hviid A. Newer-Generation Antiepileptic Drugs and the Risk of Major Birth Defects. JAMA. 2011; 305(19): 1996-2002.
  • Uludağ S,Aydın Y,Yılmaz O, Aksoy F, Bakkaoğlu D, Sen C. Multiple fetal anomalies in association with topiramate and oxcarbazepin treatment. Fetal Pediatr. Pathol. 2012; 31(3): 154-8.
  • Rolnitsky A, Merlob P, Klinger G. In utero oxcarbazepine and a withdrawal syndrome, anomalies, and hyponatremia. Pediatr. Neurol. 2013; 48(6): 466-8.
  • De O Guerra M, de Oliveira LE, Peters VM. Pre-embryo development in rats treated with oxcarbazepine in the first four days after insemination. Rev. Assoc. Med. Bras. 2000; 46(4): 346-53.
  • Ambrosio AF, Silva AP, Araujo I, Malva JO, Soares-da Silva P, Carvalho AP, Carvalho CM. Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024. J. Eur. Pharmacol. 2000; 406(2): 191-201.
  • Erisgin Z. Sıçanlarda İntrauterin Oxcarbazepin ve Gabapentin Uygulamasının Postnatal Dönemde Substantia Nigra’daki Nöron sayısına etkilerinin araştırılması. Samsun, Doktora Tezi, 2012.
  • McLean MJ. Gabapentin in the Management of Convulsive Disorders. Epilepsia.1999; 40(6): 39-50.
  • Montouris G. Gabapentin exposure in human pregnancy: results fromthe Gabapentin Pregnancy Registry. Epilepsy Behav. 2003; 4(3): 310-7.
  • Spiegel DR, Webb K. A case of treatment refractory hyperemesis gravidarum in a patient with comorbid anxiety, treated successfully with adjunctive gabapentin: a review and the potential role of neurogastroentereology in understanding its pathogenesis and treatment. Innov. Clin. Neurosci. 2012; 9(11-12): 31-8.
  • Fujii H, Goel A, Bernard N, Pistelli A, Yates LM, Stephens S, Han JY, Matsui D, Etwell F, Einarson TR, Koren G, Einarson A. Pregnancy outcomes following gabapentin use: results of a prospective comparative cohort study. Neurology. 2013; 80(17): 1565-70.
  • Nagandla K, De S. Restless legs syndrome: pathophysiology and modern management. Postgrad. Med J. 2013; 89(1053): 402-10.
  • Petrere JA, Anderson JA. Developmental Toxicity Studies in Mice, Rats, and Rabbits with the Anticonvulsant Gabapentin. Fundam. Appl. Toxicol. 1994; 23(4): 585-9.
  • Prakash, Prabhu LV, Rai R,Pai MM, Yadav SK, Madhyastha S, Goel RK, Singh G, Nasar MA. Teratogenic effects of the anticonvulsant gabapentin in mice. J. Singapore Med. 2008; 49(1): 47–53.
  • Guttuso Jr. T, Robinson LK, Amankwah KS. Gabapentin use in hyperemesis gravidarum: A pilot study. Early Human Development. 2010; 86(1): 65–6.
Toplam 123 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

Mustafa Ayyıldız Bu kişi benim

Züleyha Erişgin Bu kişi benim

Yayımlanma Tarihi 1 Mart 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 18 Sayı: 1

Kaynak Göster

APA Ayyıldız, M., & Erişgin, Z. (2016). GEBELİK ve EPİLEPSİ. Duzce Medical Journal, 18(1), 35-41.
AMA Ayyıldız M, Erişgin Z. GEBELİK ve EPİLEPSİ. Duzce Med J. Mart 2016;18(1):35-41.
Chicago Ayyıldız, Mustafa, ve Züleyha Erişgin. “GEBELİK Ve EPİLEPSİ”. Duzce Medical Journal 18, sy. 1 (Mart 2016): 35-41.
EndNote Ayyıldız M, Erişgin Z (01 Mart 2016) GEBELİK ve EPİLEPSİ. Duzce Medical Journal 18 1 35–41.
IEEE M. Ayyıldız ve Z. Erişgin, “GEBELİK ve EPİLEPSİ”, Duzce Med J, c. 18, sy. 1, ss. 35–41, 2016.
ISNAD Ayyıldız, Mustafa - Erişgin, Züleyha. “GEBELİK Ve EPİLEPSİ”. Duzce Medical Journal 18/1 (Mart 2016), 35-41.
JAMA Ayyıldız M, Erişgin Z. GEBELİK ve EPİLEPSİ. Duzce Med J. 2016;18:35–41.
MLA Ayyıldız, Mustafa ve Züleyha Erişgin. “GEBELİK Ve EPİLEPSİ”. Duzce Medical Journal, c. 18, sy. 1, 2016, ss. 35-41.
Vancouver Ayyıldız M, Erişgin Z. GEBELİK ve EPİLEPSİ. Duzce Med J. 2016;18(1):35-41.
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