Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases

Abstract

In this work, Ni(II) complexes with unsymmetric Schiff bases (NiL_1, NiL₂, NiL₃, NiL₄) were prepared by a two-stage method reported by one of us recently for investigate antimutagenic properties. Sodium azide-induced antimutagenic effect in lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus (MN) methods. It has been determined that the synthesized compounds have antimutagenic properties and reduce the mutagenicity caused by sodium azide (NaN₃) which is used as a positive control.

Keywords

• Unsymmetric diimin,Ni (II) complex,sodium azide

Asimetrik Schiff Bazı Ni(II) Komplekslerinin Antimutajenik Aktivitesinin Değerlendirilmesi

Abstract

Bu çalışmada, asimetrik Ni(II) kompleksleri (NiL_1, NiL₂, NiL₃, NiL₄) potansiyel antimutajen özelliklerini incelemek için son zamanlarda grubumuzdan biri tarafından rapor edilen yeni iki aşamalı bir yöntem ile hazırlandı. Lenfositlerdeki sodyum azid kaynaklı antimutagenik etki, kardeş kromatid değişimi (SCE) ve mikronükleus (MN) yöntemleriyle belirlendi. Sentezlenen bileşiklerin antimutagenik özelliklere sahip olduğu ve pozitif kontrol olarak kullanılan sodyum azid (NaN₃)^'ün neden olduğu mutajeniteyi azalttıkları belirlenmiştir.

Keywords

• Asimetrik diimin,Ni(II) kompleksi,sodyum azit

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