Evulation of Antimutagenic Activity of Ni(II) Complexes with Unsymmetric Schiff Bases

Yıl 2020, , 608 - 616, 31.01.2020

Dilek Nartop , Elvan Hasanoğlu Özkan Hamit Emre Kızıl , Güleray Ağar , Nurşen Sarı

https://doi.org/10.29130/dubited.575747

Cited By: 3

Öz

In this work, Ni(II) complexes with unsymmetric
Schiff bases (NiL_1, NiL₂, NiL₃, NiL₄)
were
prepared by a two-stage method reported by one of us recently for
investigate antimutagenic properties. Sodium azide-induced antimutagenic effect in
lymphocytes was determined by sister chromatid exchange (SCE) and micronucleus
(MN) methods. It has been determined that the synthesized compounds have antimutagenic
properties and reduce the mutagenicity caused by sodium azide (NaN₃)
which is used as a positive control.

Anahtar Kelimeler

Unsymmetric diimin, Ni (II) complex, sodium azide

Asimetrik Schiff Bazı Ni(II) Komplekslerinin Antimutajenik Aktivitesinin Değerlendirilmesi

Öz

Bu çalışmada,
asimetrik Ni(II) kompleksleri (NiL_1, NiL₂, NiL₃, NiL₄) potansiyel antimutajen özelliklerini incelemek için son zamanlarda
grubumuzdan biri tarafından rapor edilen yeni iki aşamalı bir yöntem ile hazırlandı. Lenfositlerdeki sodyum azid kaynaklı antimutagenik
etki, kardeş kromatid değişimi (SCE) ve mikronükleus (MN) yöntemleriyle belirlendi.
Sentezlenen bileşiklerin antimutagenik özelliklere sahip olduğu ve pozitif
kontrol olarak kullanılan sodyum azid (NaN₃)^'ün neden olduğu mutajeniteyi azalttıkları belirlenmiştir.

Anahtar Kelimeler

Asimetrik diimin, Ni(II) kompleksi, sodyum azit

Kaynakça

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