Biyoçözünür İmplant Uygulamaları İçin Saf Çinko Tozlarından İnce Taneli Yapıların İmalatı ve Çözünme Davranışının Karakterizasyonu

Yıl 2021, Cilt: 9 Sayı: 1, 467 - 479, 31.01.2021

Aslı Günay Bulutsuz

https://doi.org/10.29130/dubited.826029

Öz

Çalışma kapsamında Saf Zn tozlarına Yüksek Basınç Altında Burma (YBAB) uygulanarak ince taneli yapılar elde edilmiştir. 1, 5 ve 10 rotasyondan sonra elde edilen numunelerin, mikro yapıları, mekanik özellikleri ve çözünme davranışları karakterize edilmiştir. Mikro yapı incelemeleri için optik mikroskop, mekanik özellik incelemeleri için sertlik ve çekme testi uygulanmıştır. Çözünme davranışının tespiti için ise vücut sıcaklığında (37 °C) 15 gün boyunca gözlemler gerçekleştirilmiştir. Çözünme testlerinden sonra oluşan yüzey topografyası taramalı elektron mikroskobu (SEM) ile incelenmiştir. Elde edilen sonuçlara göre YBAB işlemi mikro yapıyı, mekanik özellikleri ve çözünme davranışını etkilemiştir. Sertlik 5 rotasyonda en yüksek değere ulaşmış, sonrasında tane toparlanması sebebi ile sertlik değeri düşmüştür. Bunun yanı sıra mekanik dayanım artmaya devam etmiştir. Çözünme davranışı en düşük 10. Rotasyonda elde edilirken bu değerin 5. Rotasyon ile oldukça yakın olduğu gözlemlenmiştir. Bu çalışma ile ilk defa toz Zn başlangıç numunelerinden yola çıkılarak YBAB uygulanmış karakterize edilmiş ve fosfat tamponu içerisinde çözünme davranışı gözlemlenmiştir.

Anahtar Kelimeler

Biyoçözünür, İmalat, Biyomalzeme, YBAB, UİT, Çözünme davranışı

Kaynakça

• [1] Y.P. Acklin, I Zderic, J.Buschbaum, P. Varga, .JA. Inzana, S. Grechenig, R.G. Richards, B. Gueorguiev, P. Schmitz, “Biomechanical comparison of plate and screw fixation in anterior pelvic ring fractures with low bone mineral density”. Injury, vol. 47, no. pp. 1456–1460. 2016.
• [2] H.S. Han, S. Loffredo, I. Jun, J. Edwards, Y.C. Kim, H.K. Seok, F. Witte, D. Mantovani, S. Glyn-Jones, “Current status and outlook on the clinical translation of biodegradable metals”. Materials Today, vol 23, pp. 57–71, 2019.
• [3] F. Witte, “The history of biodegradable magnesium implants: A review”. Acta Biomaterialia, vol 6, pp. 1680–1692, 2010.
• [4] C. Erkek, N. Ağıralioğlu, M. Moravej, D. Mantovani . “Biodegradable metals for cardiovascular stent application: Interests and new opportunities”. International Journal of Molecular Sciences, vol 12, pp. 4250–4270, 2011.
• [5] D. Noviana, D. Paramitha, M.F. Ulum, H. Hermawan, “The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats”. Journal of Orthopaedic Translation, vol 5, pp 9–15, 2016.
• [6] E. Scarcello, I. Lobysheva, C. Bouzin, Jacques PJ, Lison D, Dessy C. “Endothelial dysfunction induced by hydroxyl radicals – the hidden face of biodegradable Fe-based materials for coronary stents”. Materials Science and Engineering C, vol 112,pp 1-11,2020.
• [7] T.C. Paim, D.P. Wermuth, I. Bertaco, C. Zanatelli, L.I.S. Naasani, M. Slaviero, D. Driemeier, L. Schaeffer, M.R. Wink, “Evaluation of in vitro and in vivo biocompatibility of iron produced by powder metallurgy”. Materials Science and Engineering C, vol 115, pp. 1-11,2020.
• [8] E. Bruder, P. Braun, H. Rehman, R.K.W. Marceau, A.S. Taylor, R. Pippan, K. Durst. “Influence of solute effects on the saturation grain size and rate sensitivity in Cu-X alloys”. Scripta Materialia, vol 144, pp 5–8, 2018.
• [9] M. Furukawa,Y. Iwahashi, Z. Horita, M. Nemoto, T.G. Langdon, “The shearing characteristics associated with equal-channel angular pressing”. Materials Science and Engineering A, vol 257, pp 328–332, 1998.
• [10] A.G. Bulutsuz, W. Chrominski, Y. Huang, P. Kral P, M.E. Yurci, M. Lewandowska, T.G. Langdon, “A Comparison of Warm and Combined Warm and Low-Temperature Processing Routes for the Equal-Channel Angular Pressing of Pure Titanium”. Advanced Engineering Materials, vol 22, pp 1-8,2020.
• [11] K. Özbeyaz, H. Kaya, A. Kentli, M. Şahbaz, S. Öğüt, “Mechanical properties and electrical conductivity performance of ECAP processed AA2024 alloy”. Indian Journal Of Chemical Technology, vol 26, pp 266-269, 2019.
• [12] A. Günay Bulutsuz, M.E. Yurci, N. Durakbaşa, “Optimization Process Parameters of Equal Angular Channel Pressing According to the Measurement Results of Microstructural Homogeneity”. Materials Research, vol 21, no 6, pp 1-9, 2018.
• [13] A. Günay Bulutsuz, Ö. Berrak, H. A. Yeprem, E.D. Arisan, M.E. Yurci, “Biological responses of ultrafine grained pure titanium and their sand blasted surfaces”. Materials Science and Engineering C, vol 91, pp 382–388, 2018.
• [14] Q. Li, W. Ye, H. Gao, L. Gao, “Improving the corrosion resistance of ZEK1 00 magnesium alloy by combining high-pressure torsion technology with hydroxyapatite coating”. Materials and Design, vol 181,pp 1-14, 2019.
• [15] B. Srinivasarao, A.P. Zhilyaev, T.G. Langdon, M.T. Pérez-Prado, “On the relation between the microstructure and the mechanical behavior of pure Zn processed by high pressure torsion”. Materials Science and Engineering A, vol 562, pp 196–202, 2013.
• [16] A. Ojdanic, J. Horky, B. Mingler, M. Fanetti, S. Gardonio, M. Valant, B. Sulkowski, E. Schafler, D. Orlov, M.J. Zehetbauer, M. Fanetti, S. Gardonio, M. Valant, B. Sulkowski, E. Schafler, “The effects of severe plastic deformation and/or thermal treatment on the mechanical properties of biodegradable mg-alloys”. Metals, vol 10, no 8, pp 1-33,2020
• [17] D.M Brasher, J.G. Beynon, K.S. Rajagopalan, J.G.N. Thomas, “Passivity of iron in chromic acid solutions” British Corrosion Journal, vol 5, no 6, pp 264-269, 2013.
• [18] ASTM, Standard Practice for Preparing, Cleaning, and Evaluating Corrosion Test Specimens, ASTM Standard G1-03. 2011 Annual Book of ASTM Standards 03.02 ASTM, Philadelphia. PA, 2011.
• [19] B.H. Park, H.Y. Um, J.G. Kim, H.Y. Jeong, S. Lee, H.S. Kim, “Large deformation behavior of twin-induced plasticity steels under high-pressure torsion”. Metals and Materials International, vol 22, pp 1003–1008, 2016.
• [20] Edalati K, Horita Z, “Significance of homologous temperature in softening behavior and grain size of pure metals processed by high-pressure torsion”. Materials Science Engineering, 528, 7514-7523, 2011.
• [21] Y. Meng, L. Liu, D. Zhang, C. Dong, Y. Yan, A.A. Volinsky, L.N. Wang, “Initial formation of corrosion products on pure zinc in saline solution” Bioactive Materials, vol 4, no 1, pp87-96,2019.
• [22] D. Vojtěch, J. Kubásek, J. Šerák, P. Novák, “Mechanical and corrosion properties of newly developed biodegradable Zn-based alloys for bone fixation”. Acta Biomaterialia, vol 7, p 3515–3522, 2011.
• [23] Mostaed E, Sikora-Jasinska M, Mostaed A, Loffredo S, Demir AG, Previtali B, Mantovani D, Beanland R, Vedani M, “Novel Zn-based alloys for biodegradable stent applications: Design, development and in vitro degradation”. Journal of the Mechanical Behavior of Biomedical Materials, 60, 581–602, 2016.
• [24] H. Li, H. Yang, Y. Zheng, F. Zhou, K. Qiu, X. Wang, “Design and characterizations of novel biodegradable ternary Zn-based alloys with IIA nutrient alloying elements Mg, Ca and Sr”. Materials and Design, vol 83, pp 95–102, 2015.
• [25] D. Ahmadkhaniha, Y. Huang, M. Jaskari, A. Järvenpää, M.H. Sohi, C. Zanella, L.P. Karjalainen, T.G. Langdon, “Effect of high-pressure torsion on microstructure, mechanical properties and corrosion resistance of cast pure Mg”. Journal of Materials Science, vol 53, pp 16585-16597, 2018.
• [26] D. Orlov, K.D. Ralston, N. Birbilis, Y. Estrin, “Enhanced corrosion resistance of Mg alloy ZK60 after processing by integrated extrusion and equal channel angular pressing”. Acta Materialia, vol 59, no 15, pp 6176-6186, 2011.
• [27] P. Guo, X. Zhu, L. Yang, L. Deng, Q. Zhang , B.Q. Li, K. Cho, W. Sun, T. Ren, Z. Song, “Ultrafine- and uniform-grained biodegradable Zn-0.5Mn alloy: Grain refinement mechanism, corrosion behavior, and biocompatibility in vivo”. Materials Science and Engineering C, vol 118, pp 1-12, 2021.
• [28] J. Tang, J. Wang, X. Xie, P. Zhang, Y. Lai, Y. Li, L. Qin “Surface coating reduces degradation rate of magnesium alloy developed for orthopaedic applications”. Journal of Orthopaedic Translation, vol 1, pp 41–48, 2013.
• [29] E.l. Abd, E.E. Aal, “Factors affecting the anodic behaviour of zinc electrode in borate solutions” Corrosion Science vol. 48, pp 343–360,2006.
• [30] C. Shen, X. Liu, B. Fan, P. Lan, F. Zhou, X. Li, H. Wang, X. Xiao, L. Li, S. Zhao, Z. Guo, Z. Pu, Y. Zheng, “Mechanical properties,: In vitro degradation behavior, hemocompatibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants”. RSC Advances, vol 89, no 6, pp 86410–86419, 2016.
• [31] H. Tapiero, K.D. Tew, “Trace elements in human physiology and pathology: zinc and metallothioneins”. Biomedical Pharmacotherapy, vol 57, no 9, pp 386–398, 2003.