Dopaminin Elektrokimyasal Tayini için Bazı Taç Eter Bileşiklerinin Kullanımının Araştırılması

Yıl 2024, Cilt: 12 Sayı: 4, 2185 - 2199, 23.10.2024

İrem Okman Koçoğlu

https://doi.org/10.29130/dubited.1463687

Öz

Bu çalışmada çok duvarlı karbon nanotüp (MWCNT) modifiye edilmiş camsı karbon elektrot (GCE) yüzeylerine farklı taç eter bileşiklerinin (CE1, CE2 ve CE3) elektropolimerizasyonu ile hazırlanan üç farklı taç eter-modifiye elektrodun elektrokimyasal dopamin tayininde kullanımı araştırıldı. Taç eterlerin elektropolimerizasyonu sırasındaki döngü sayısı ve çalışılan tampon çözelti pH’sı optimize edildi. Optimum koşullarda, MWCNT modifiye edilmiş GCE ile taç eter-MWCNT-modifiye elektrotların 4,0×10-6 − 5,7×10-4 M dopamin derişimi aralığında duyarlılıkları belirlendi. MWCNT/GCE’nin duyarlılığı 6,71 µA mM-1 olarak bulunurken, CE1/MWCNT/GCE, CE2/MWCNT/GCE ve CE3/MWCNT/GCE’nin duyarlılıkları sırasıyla 19,53; 16,32 ve 20,80 µA mM-1 olarak belirlendi. Taç eter-modifiye elektrotların gözlenebilme sınırı, tayin sınırı, tekrar kullanılabilirlik ve tekrar üretilebilirlik gibi performans özellikleri de incelendi. Çalışma, taç eter bileşiklerinin dopamin tayininde elektrokimyasal cevabı önemli ölçüde arttırdığını ve dopamin tayinine olumlu yönde etki ettiğini gösterdi.

Anahtar Kelimeler

Taç eter, Elektrokimyasal sensör, Dopamin, Modifiye elektrot, Çok duvarlı karbon nanotüp

Destekleyen Kurum

Karabük Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

KBÜBAP-24-DS-039

Teşekkür

Bu çalışma Karabük Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından desteklenmiştir. Proje Numarası: KBÜBAP-24-DS-039

Investigation of Some Crown Ether Compounds for Electrochemical Determination of Dopamine

Öz

In this study, the use of three different crown ether-modified electrodes prepared by electropolymerization of different crown ether compounds (CE1, CE2 and CE3) on multi-walled carbon nanotube (MWCNT) modified glassy carbon electrode (GCE) surfaces was investigated for electrochemical dopamine determination. The number of cycles during the electropolymerization of crown ethers and the pH of the buffer solution were optimized. Under optimum conditions, the sensitivities of MWCNT-modified GCE and crown ether-MWCNT-modified electrodes were determined in the range of 4.0×10-6 – 5.7×10-4 M dopamine. The sensitivity of MWCNT/GCE was found to be 6.71 µA mM-1, while the sensitivities of CE1/MWCNT/GCE, CE2/MWCNT/GCE and CE3/MWCNT/GCE were 19.53, 16.32 and 20.80 µA mM-1, respectively. The performance characteristics of the crown ether-MWCNT-modified electrodes such as detection limit, quantification limit, reusability and reproducibility were also investigated. The study showed that crown ether compounds significantly enhanced the electrochemical response in dopamine determination.

Anahtar Kelimeler

Crown ether, Electrochemical sensor, Dopamine, Modified electrode, Multi-walled carbon nanotube

Destekleyen Kurum

Karabük University Scientific Research Projects Coordination Unit

Proje Numarası

KBÜBAP-24-DS-039

Teşekkür

This study is supported by Karabük University Scientific Research Projects Coordination Unit. Project Number: KBÜBAP-24-DS-039

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