Metotreksat Kullanıma Bağlı Pansitopeni

Yıl 2020, Cilt: 2 Sayı: 3, 76 - 77, 05.12.2020

Fatih Güneysu Ayhan Sarıtaş Ensar Durmuş Semih Güneysu

Öz

Methotrexate;
Folic acid analogue and antagonist, commonly used immunosuppressive agent. It
is used as long-term and low-dose in patients with rheumatoid arthritis.
Although anemia, thrombocytopenia or leukopenia are rare in hematological
toxicity of low-dose MTX therapy, pancytopenia is rarely encountered. Herein,
we aimed to present a case with pancytopenia due to MTX use.

Anahtar Kelimeler

Pancytopeni, methotrexate, emergency

Metotreksat Kullanıma Bağlı Pansitopeni

Öz

Metotreksat; folik asit analoğu ve antagonisti olup, sık kullanılan immunsupresif ajandır. Romatoid artrit hastalarında uzun süreli ve düşük dozlu olarak kullanılmaktadır.
Düşük doz MTX tedavisinin hematolojik toksisitesinde anemi, trombositopeni veya lökopeni durumları az görülmesine rağmen pansitopeni
çok daha nadir olarak karşımıza çıkmaktadır. Biz burada, MTX kullanımına bağlı pansitopeni gelişen olguyu sunmayı amaçladık.

Anahtar Kelimeler

pansitopeni, metotreksat, acil

Kaynakça

• 1- van Ede AE, Laan RF, Blom HJ, De Abreu RA, van de Putte LB. Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity. Semin Arthritis Rheum 1998;27:277-92
• 2- Joel M Kremer, James R O'Dell, Paul L Romain, Major Side Effects Of Low-Dose Methotrexate. In uptodate.com, Oct 2019.
• 3- Boulanger H, Launay-Vacher V, Hierniaux P, Fau JB, Deray G. Severe methotrexate intoxication in a haemodialysis patient treated for rheumatoid arthritis. Nephrol Dial Transplant 2001;16:1087.
• 4- van Ede AE, Laan RF, Rood MJ. Effect Of Folic Or Folinic Acid Supplementation On The Toxicity And Efficacy Of Methotrexate In Rheumatoid Arthritis: A Forty-Eight Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study. Arthritis Rheum 2001; 44:1515.
• 5- Saag KG, Teng GG, Patkar NM. American College Of Rheumatology 2008 Recommendations For The Use Of Nonbiologic And Biologic Disease-Modifying Antirheumatic Drugs In RheumatoidArthritis. Arthritis Rheum 2008; 59:762.
• 6- Weinblatt ME, Fraser P. Elevated Mean Corpuscular Volume As A Predictor Of Hematologic Toxicity Due To Methotrxate Therapy. Aerthritis Rheum 1989; 32:1592
• 7- Gutierrez-Ureña S, Molina JF, García CO. Pancytopenia Secondary To Methotrexate Therapy İn Rheumatoid Arthritis. Arthritis Rheum 1996; 39:272.
• 8- Kremer JM, Maini RN, Romain PL. Major Side Effects Of Low-DoseMethotrexate. Uptodate 2009; 17.1Version. 3. Altındağ Ö, Küçükoğlu B. Intoxication Due To High Dose Methotrexate İn A Patient With Arthritis: A case report. Turk J Rheu-matol 2011; 26: 58-60.