PHYTOEQUIVALENCY OF GINKGO BILOBA PRODUCTS: PHARMACOPOEIAL METHOD

Year 2021, Volume: 4 Issue: 1, 1 - 9, 04.07.2021

Haleh Piri Beste Atli Nesrin Oztinen Ezgi Ak-sakalli Muberra Kosar

Abstract

Ginkgo biloba L., maidenhair tree, is the only living species in the Ginkgophyta division. Standardized G. biloba extracts is used within the pharmaceutical preparations for the treatment of Alzheimer's and Parkinson’s diseases, as well as vascular dementia, vascular tinnitus, and toxicological properties. Plant extract contains three different active chemical classes: Flavonoids (kaempferol, meletin, isorhamnetin, etc.), terpenoids (ginkgolides A, B, and C), and ginkgolic acid. In this study, the commercial preparations obtained from the pharmacy were analysed and compared with standard medicine according to their chemical compositions. Chemical analyses were performed by reverse phase High Performance Liquid Chromatography (HPLC). Seven commercial products were analyzed and compared with standardized extract contained medicine Tebokan® (Abdi Ibrahim, Turkey) by HPLC. While none of the commercial product was found to be equal to the Tebokan®, only one product was investigated similarly according to the important chemical compounds. Quercetin and Isorhamnetin were evaluated in all samples and the standard as well.

Keywords

Ginkgo biloba, HPLC, quercetin, isorhamnetin

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