Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Yıl 2018, Sayı: 2, 135 - 142, 19.08.2018

Sevda Manap Fevzi Aytemız Haydar Yuksek

Öz

In this study, 3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones
(1) were treated with morpholine in the presence of formaldehyde according to
the Mannich reaction to synthesize five novel
1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2). In addition, the antioxidant properties of compounds 2 were analyzed and evaluated using three antioxidant assays,
including reducing power, free radical scavenging and metal chelating activity.
For the measurement of the reductive ability, Fe³⁺-Fe²⁺
transformation was investigated in the presence of compound using by the method
of Oyaizu (1986). The hydrogen atoms or
electrons donation ability of the synthesized compound was measured by DPPH^. using the method of Blois (1958). The chelating effect of ferrous ions by the
compound was determined according to the method of Dinis, Madeira & Almeida (1994). BHT, BHA, EDTA and α-tocopherol
were used as reference antioxidant compounds.

Anahtar Kelimeler

1, 2, 4-Triazol-5-one, Mannich base, Antioxidant activity

Kaynakça

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