Manifestation of Ankylosing Spondylitis and Crohn`s Disease

Yıl 2018, Sayı: 2, 259 - 261, 19.08.2018

Olena Sulıma Volodymyr Sulyma

Öz

Regional or granulomatous ileitis is a chronic
bowel disease (Crohn's disease) that covers all the layers of the intestinal
wall (transmural lesions), and sometimes spreads to the mesentery, regional
lymph nodes affecting both the small and large intestines, but most often
localized in the terminal section of a thin guts (regional, terminal ileitis). These
diseases can be accompanied by damage to the peripheral joints, spine, or
joints and spine. The clinical manifestations of the joint syndrome in both
processes are the same. The pathogenesis of the intestinal process and joint
damage has not been fully established, but it is believed that many mechanisms
participate in it, and in particular, toxic, immune, autoimmune. In the blood
of patients, antibodies to the cells of the intestinal mucosa, lymphocytotoxin
antibodies, circulating immune complexes, in which, possibly, antigenic
components of intestinal microbes, etc., are also present. In Crohn's disease,
articular manifestations usually occur in childhood and adolescence. The development
of peripheral arthritis in these diseases is usually not associated with the
carriage of the histocompatibility antigen B27. Ankylosing spondylitis is more
common in men than in women (3: 1). This disease usually develops in people who
have HLA B27. Articular changes with regional ileitis occur more often in
patients with other extraintestinal manifestations of the processes - with
ulcers of the oral mucosa, exacerbate erythema nodosum, gangrenous pyoderma.

Anahtar Kelimeler

Ankylosing spondylitis, Crohn's disease, Manifestation

Kaynakça

• Braun J, Sieper J. Ankylosing spondylitis. Lancet. 2007;369:1379–1390. [PubMed] Jacques P, Elewaut D. Joint expedition: linking gut inflammation to arthritis. Mucosal Immunol. 2008;1:364– 371. [PubMed] Mielants H, Veys EM, Cuvelier C, De Vos M, Goemaere S, et al. The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects. J Rheumatol. 1995;22:2273–2278. [PubMed] Thjodleifsson B, Geirsson AJ, Bjornsson S, Bjarnason I. A common genetic background for inflammatory bowel disease and ankylosing spondylitis: a genealogic study in Iceland. Arthritis Rheum. 2007;56:2633–2639. [PubMed] Danoy P, Pryce K, Hadler J, Bradbury LA, Farrar C, et al. Association of variants at 1q32 and STAT3with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet. 2010;6:e1001195.doi: 10.1371/journal.pgen.1001195. [PMC free article] [PubMed] Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet. 2008;40:955–962. [PMC free article][PubMed] Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, et al. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet. 2007;39:1329– 1337.[PMC free article] [PubMed]