Yıl 2019, Cilt 7 , Sayı , Sayfalar 63 - 67 2019-11-24

Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds

Hiba Amin AL-ALAAF [1] , Mohammed Ahmed AL-IRAQI [2]


Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (3) is one of the important heterocyclic compounds. It is used as a precursor to synthesize new derivatives of quinazolin-4-one moiety. The compound (4) was synthesized via a series of steps from anthranilic acid. Firstly, the anthranilic acid was converted to its methyl ester (1) by esterification with methanol under acidic condition. The ester (1) was reacted with chloroacetyl chloride to produce methyl α-chloroacetamido benzoate (2). The chloro compound (2) was converted to the to the target precursor (3) by boiling of the chloro compound (2) with ammonium thiocyanate for 12 h. The compound (3) was used as synthon to synthesize new series of five membered ring heterocyclic derivatives, via its conversion to the corresponding acid hydrazide (4). The acid hydrazide (4) was reacted with carbon disulfide under boiling condition to produce 1,3,4-oxadiazole-5-thione derivative (5). The oxadiazole compound (5) was reacted with alkyl halides to afforded the corresponding alkylthio compounds (6-11), and with aromatic aldehydes to afforded the carbinol derivatives (12-18). The synthesized compounds were identified via the physical and spectral data.
2-Mercaptoquinazolin-4-one, Methyl 2-chloroacetaminobenzoate, Methyl anthranilate, Alkylthio derivatives, Acetohydrazide compounds, 1, 3, 4 Oxadiazol
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Birincil Dil en
Konular Mühendislik
Bölüm Makaleler
Yazarlar

Yazar: Hiba Amin AL-ALAAF
Kurum: University of Mosul
Ülke: Iraq


Yazar: Mohammed Ahmed AL-IRAQI
Kurum: University of Mosul
Ülke: Iraq


Tarihler

Yayımlanma Tarihi : 24 Kasım 2019

Bibtex @araştırma makalesi { epstem652635, journal = {The Eurasia Proceedings of Science Technology Engineering and Mathematics}, issn = {}, eissn = {2602-3199}, address = {isresoffice@gmail.com}, publisher = {ISRES Organizasyon Turizm Eğitim Danışmanlık Ltd. Şti.}, year = {2019}, volume = {7}, pages = {63 - 67}, doi = {}, title = {Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds}, key = {cite}, author = {AL-ALAAF, Hiba Amin and AL-IRAQI, Mohammed Ahmed} }
APA AL-ALAAF, H , AL-IRAQI, M . (2019). Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds. The Eurasia Proceedings of Science Technology Engineering and Mathematics , 7 () , 63-67 . Retrieved from https://dergipark.org.tr/tr/pub/epstem/issue/50288/652635
MLA AL-ALAAF, H , AL-IRAQI, M . "Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds". The Eurasia Proceedings of Science Technology Engineering and Mathematics 7 (2019 ): 63-67 <https://dergipark.org.tr/tr/pub/epstem/issue/50288/652635>
Chicago AL-ALAAF, H , AL-IRAQI, M . "Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds". The Eurasia Proceedings of Science Technology Engineering and Mathematics 7 (2019 ): 63-67
RIS TY - JOUR T1 - Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds AU - Hiba Amin AL-ALAAF , Mohammed Ahmed AL-IRAQI Y1 - 2019 PY - 2019 N1 - DO - T2 - The Eurasia Proceedings of Science Technology Engineering and Mathematics JF - Journal JO - JOR SP - 63 EP - 67 VL - 7 IS - SN - -2602-3199 M3 - UR - Y2 - 2020 ER -
EndNote %0 The Eurasia Proceedings of Science Technology Engineering and Mathematics Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds %A Hiba Amin AL-ALAAF , Mohammed Ahmed AL-IRAQI %T Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds %D 2019 %J The Eurasia Proceedings of Science Technology Engineering and Mathematics %P -2602-3199 %V 7 %N %R %U
ISNAD AL-ALAAF, Hiba Amin , AL-IRAQI, Mohammed Ahmed . "Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds". The Eurasia Proceedings of Science Technology Engineering and Mathematics 7 / (Kasım 2019): 63-67 .
AMA AL-ALAAF H , AL-IRAQI M . Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds. EPSTEM. 2019; 7: 63-67.
Vancouver AL-ALAAF H , AL-IRAQI M . Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate as Precursor to New Heterocyclic Compounds. The Eurasia Proceedings of Science Technology Engineering and Mathematics. 2019; 7: 67-63.