Akdeniz Üniversitesi Bilimsel Araştırma Projeleri
TDK-2019-4584
Quantification of consecutive motor unit potential (MUP) is used to diagnose and monitor the progress of neuromuscular pathologies in clinical applications. In this study, a detailed motor unit simulation was conducted to reveal and understand the factors affecting MUPs. Using a volume conductor model and real muscle parameters, normal and pathologic MUPs were created. The shape changes observed in consecutive MUPs, called jiggle, are calculated with a quantification method. Increased jitter duration and re-innervation percentage commonly observed during motor unit loss increase the jiggle value proportionally. Moreover, increasing fiber density changing different regions of a muscle bundle decreases the jiggle value. The blocking phenomena generally observed in re-innervated fibers affects the jiggle value similar to jitter duration. But, higher blocking levels (50%) of re-innervated motor fiber do not have an effect on jiggle value as lower levels of blocking (20%). In conclusion, simulation of pathological MUPs showed that it is useful for clinicians to understand the progress of a neuromuscular pathology and the factors affecting consecutive MUP wave shape.
Motor Unit Action Potential Neuromuscular Pathology Motor Unit Instability Motor Unit Simulation
TDK-2019-4584
Birincil Dil | İngilizce |
---|---|
Bölüm | Makaleler |
Yazarlar | |
Proje Numarası | TDK-2019-4584 |
Yayımlanma Tarihi | 28 Aralık 2020 |
Yayımlandığı Sayı | Yıl 2020 Cilt: 21 Sayı: 4 |