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Yıl 2019, Cilt: 5 Sayı: 1, 166 - 173, 04.01.2019
https://doi.org/10.18621/eurj.411682

Öz

Kaynakça

  • [1] Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007;37:31-7.
  • [2] Kawamukai M. Biosynthesis of coenzyme Q in eukaryotes. Biosci Biotechnol Biochem 2016;80:23-33.
  • [3] Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24:579-84.
  • [4] Saini R. Coenzyme Q10: the essential nutrient. J Pharm Bioallied Sci 2011;3:466-7.
  • [5] Marcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol 2007;49:2231-7.
  • [6] Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Fernández Vega A, de la Mata M, Delgado Pavón A, et al. Coenzyme q10 therapy. Mol Syndromol 2014;5:187-97.
  • [7] Braillon A. Coenzyme Q10 and statin-induced myopathy--II. Mayo Clinic Proc 2015;90:420.
  • [8] Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strategies. Critical Rev Food Sc iNutr 2010;50:269-80.
  • [9] Žmitek K, Pogačnik T, Mervic L, Žmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 on skin parameters and condition: results of a randomised, placebo-controlled, double-blind study. Biofactors 2017;43:132-40.
  • [10] De Luca C, Mikhal'chik EV, Suprun MV, Papacharalambous M, Truhanov AI, Korkina LG. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid Med Cell Longev 2016;2016:4389410.
  • [11] Rona C, Vailati F, Berardesca E. The cosmetic treatment of wrinkles. J Cosmet Dermat 2004;3:26-34.
  • [12] Chiu A, Kimball A. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003;149:681-91.
  • [13] Johansson P, Dahlström Ö, Dahlström U, Alehagen U. Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double blind, placebo-controlled prospective study. J Nutr Health Aging 2015;19:870-7.
  • [14] González-Guardia L, Yubero-Serrano EM, Delgado-Lista J, Perez-Martinez P, Garcia- Rios A, Marin C, et al. Effects of the Mediterranean diet supplemented with coenzyme q10 onmetabolomic profiles in elderly men and women. J Gerontol A Biol Sci Med Sci 2015;70:78-84.
  • [15] Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. JACC Heart Fail 2014;2:641-49.
  • [16] Sander S, Coleman CI, Patel AA, Kluger J, White CM. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail 2006;12:464-72.
  • [17] Onur S, Niklowitz P, Jacobs G, Lieb W, Menke T, Döring F. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, inhealthy elderly subjects. Biofactors 2015;41:35-43.
  • [18] Johansson P, Dahlström Ö, Dahlström U, Alehagen U. Effect of selenium and Q10 on the cardiac biomarker NT-proBNP. Scand Cardiovasc J 2013;47:281-8.
  • [19] Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzymeQ10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol 2013;167:1860-6.
  • [20] Alehagen U,Alexander J, Aaseth J. Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. A secondary analysis of a randomised clinical trial. PLoS One 2016;11:e0157541.
  • [21] Alehagen U, Aaseth J, Johansson P. Reduced cardiovascular mortality 10 years after supplementation with selenium and coenzyme Q10 for four years: follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. PLoS One 2015;10:e0141641.
  • [22] Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012;28:250-5.
  • [23] Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition 2012;28:767-72.
  • [24] Mirhashemi SM, Najafi V, Raygan F, Asemi Z. The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: a randomized, double-blind, placebo-controlled trial. ARYA Atheroscler 2016;12:158-65.
  • [25] Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzymeQ10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J 2013;12(1):142.
  • [26] Lonnrot K, PorstiI, Alho H, Wu X, Hervonen A, Tolvanen JP. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br J Pharmacol 1998;124:1500-6.
  • [27] Langsjoen H, Langsjoen P, Willis R, Willis R, Folkers K. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med 1994;15Suppl:s165-75.
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Coenzyme Q10 deficiency in elderly: Can nutritional supplementation play a role? Mini review

Yıl 2019, Cilt: 5 Sayı: 1, 166 - 173, 04.01.2019
https://doi.org/10.18621/eurj.411682

Öz

Coenzyme
Q10 (CoQ10), an important mitochondrial redox component, plays a pivotal role
in cellular energy production; moreover, it is the only lipid-soluble
antioxidant endogenously synthesized in humans. Given its function and physiological
importance, it is not surprising that CoQ10 deficiency may result in several
diseases. With aging, humans begin to lose the ability to synthesize CoQ10 from
food, resulting in reduced serum levels
of CoQ10 and contributing to aging-associated symptoms. Poor eating habits,
infections, stress and also some drugs, as beta blockers,
antihypertensive agents and statns,
may reduce serum levels
of CoQ10. Dietary supplementation has been proposed as key strategy to increase
CoQ10 availability, improving health status in elderly; however CoQ10 is not
approved by U.S. Food and Drug Administration for the treatment of any medical
condition and it is sold only as a dietary supplement. Aim of the study was to
examine the latest relevant evidences on potential benefits of CoQ10 nutritional
supplement and its implication in improving health status in elderly. There is
evidence that, in elderly, oral administration of CoQ10 reduces oxidative
stress and inflammatory markers and reduces cardiovascular mortality; in
diabetics CoQ10 treatment improves insulin sensitivity and decreases glycated
hemoglobin. Therapeutic benefit from CoQ10 supplementation has also been
obtained in neurodegenerative diseases as Parkinson’s, Alzheimer’s and
Huntington's diseases. CoQ10 supplements could be useful in several aging-
related clinical conditions; however, well standardized long-term and larger
further studies are needed. 

Kaynakça

  • [1] Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments. Mol Biotechnol 2007;37:31-7.
  • [2] Kawamukai M. Biosynthesis of coenzyme Q in eukaryotes. Biosci Biotechnol Biochem 2016;80:23-33.
  • [3] Kalen A, Appelkvist EL, Dallner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24:579-84.
  • [4] Saini R. Coenzyme Q10: the essential nutrient. J Pharm Bioallied Sci 2011;3:466-7.
  • [5] Marcoff L, Thompson PD. The role of coenzyme Q10 in statin-associated myopathy: a systematic review. J Am Coll Cardiol 2007;49:2231-7.
  • [6] Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Fernández Vega A, de la Mata M, Delgado Pavón A, et al. Coenzyme q10 therapy. Mol Syndromol 2014;5:187-97.
  • [7] Braillon A. Coenzyme Q10 and statin-induced myopathy--II. Mayo Clinic Proc 2015;90:420.
  • [8] Pravst I, Zmitek K, Zmitek J. Coenzyme Q10 contents in foods and fortification strategies. Critical Rev Food Sc iNutr 2010;50:269-80.
  • [9] Žmitek K, Pogačnik T, Mervic L, Žmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 on skin parameters and condition: results of a randomised, placebo-controlled, double-blind study. Biofactors 2017;43:132-40.
  • [10] De Luca C, Mikhal'chik EV, Suprun MV, Papacharalambous M, Truhanov AI, Korkina LG. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid Med Cell Longev 2016;2016:4389410.
  • [11] Rona C, Vailati F, Berardesca E. The cosmetic treatment of wrinkles. J Cosmet Dermat 2004;3:26-34.
  • [12] Chiu A, Kimball A. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003;149:681-91.
  • [13] Johansson P, Dahlström Ö, Dahlström U, Alehagen U. Improved health-related quality of life, and more days out of hospital with supplementation with selenium and coenzyme Q10 combined. Results from a double blind, placebo-controlled prospective study. J Nutr Health Aging 2015;19:870-7.
  • [14] González-Guardia L, Yubero-Serrano EM, Delgado-Lista J, Perez-Martinez P, Garcia- Rios A, Marin C, et al. Effects of the Mediterranean diet supplemented with coenzyme q10 onmetabolomic profiles in elderly men and women. J Gerontol A Biol Sci Med Sci 2015;70:78-84.
  • [15] Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. JACC Heart Fail 2014;2:641-49.
  • [16] Sander S, Coleman CI, Patel AA, Kluger J, White CM. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. J Card Fail 2006;12:464-72.
  • [17] Onur S, Niklowitz P, Jacobs G, Lieb W, Menke T, Döring F. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, inhealthy elderly subjects. Biofactors 2015;41:35-43.
  • [18] Johansson P, Dahlström Ö, Dahlström U, Alehagen U. Effect of selenium and Q10 on the cardiac biomarker NT-proBNP. Scand Cardiovasc J 2013;47:281-8.
  • [19] Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzymeQ10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol 2013;167:1860-6.
  • [20] Alehagen U,Alexander J, Aaseth J. Supplementation with selenium and coenzyme Q10 reduces cardiovascular mortality in elderly with low selenium status. A secondary analysis of a randomised clinical trial. PLoS One 2016;11:e0157541.
  • [21] Alehagen U, Aaseth J, Johansson P. Reduced cardiovascular mortality 10 years after supplementation with selenium and coenzyme Q10 for four years: follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly citizens. PLoS One 2015;10:e0141641.
  • [22] Lee BJ, Huang YC, Chen SJ, Lin PT. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition 2012;28:250-5.
  • [23] Lee BJ, Huang YC, Chen SJ, Lin PT. Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease. Nutrition 2012;28:767-72.
  • [24] Mirhashemi SM, Najafi V, Raygan F, Asemi Z. The effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: a randomized, double-blind, placebo-controlled trial. ARYA Atheroscler 2016;12:158-65.
  • [25] Lee BJ, Tseng YF, Yen CH, Lin PT. Effects of coenzymeQ10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial. Nutr J 2013;12(1):142.
  • [26] Lonnrot K, PorstiI, Alho H, Wu X, Hervonen A, Tolvanen JP. Control of arterial tone after long-term coenzyme Q10 supplementation in senescent rats. Br J Pharmacol 1998;124:1500-6.
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Toplam 94 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Reviews
Yazarlar

Angelo Michele Carella 0000-0003-4825-9620

Teresa Marinelli Bu kişi benim 0000-0002-6132-3183

Michele Di Pumpo Bu kişi benim 0000-0001-7626-4879

Giovanni Modola Bu kişi benim 0000-0001-6236-7922

Angelo Benvenuto Bu kişi benim 0000-0001-5964-4706

Yayımlanma Tarihi 4 Ocak 2019
Gönderilme Tarihi 1 Nisan 2018
Kabul Tarihi 2 Mayıs 2018
Yayımlandığı Sayı Yıl 2019 Cilt: 5 Sayı: 1

Kaynak Göster

AMA Carella AM, Marinelli T, Di Pumpo M, Modola G, Benvenuto A. Coenzyme Q10 deficiency in elderly: Can nutritional supplementation play a role? Mini review. Eur Res J. Ocak 2019;5(1):166-173. doi:10.18621/eurj.411682

e-ISSN: 2149-3189 


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