Yıl 2019, Cilt 5 , Sayı 5, Sayfalar 800 - 808 2019-09-04

Evaluation of high molecular weight cytokeratin (HMWCK), p27, C-X-C chemokine receptor type 4 (CXCR-4) and stromal cell-derived factor 1 (SDF-1) expressions related to tumor progression in breast cancer

Gonca ÖZGÜN [1] , Gülen AKYOL [2]

Objectives: Breast cancer is the most common cancer and the most common reason for cancer death in women population. The immunohistochemical markers which could have prognostic information are always needed.

Methods: This study included 365 cases of invasive ductal carcinoma (IDC), ductal carcinoma in situ (DCIS) and ductal epithelial hyperplasia. The cases divided into the following two groups according to the presence of cancer: 1) cancer group (298 cases; cases with IDC and DCIS), 2) non-cancer group (67 cases without cancer; cases with usual ductal epithelial hyperplasia [UDH] and atypical ductal epithelial hyperplasia [ADH]). All histological slides stained with high molecular weight cytokeratin (HMWCK), p27, C-X-C chemokine receptor type 4 (CXCR-4), stromal cell-derived factor 1 (SDF-1) immunohistochemically.

Results: IDC was present in 277 cases, of which 213 had pure IDC, and 64 had DCIS component adjacent to the invasive tumor. Twenty-one cases had only DCIS. Of 67 cases with epithelial hyperplasia, 31 had ADH, and 36 had UDH. Among cases with IDC, 143 had lymph node excision, of which 73 had metastasis in one or more lymph nodes, and 70 did not have metastatic disease. The expression of p27 was found to be significantly lower in the cancer group as compared to that in the non-cancer group (p < 0.0001). CXCR-4 expression in IDC was found to be higher than that of DCIS group. SDF-1 expression was observed to be significantly higher in cancer cases than that of non-cancer cases (p = 0.03).

Conclusions: The higher CXCR-4 and SDF-1 expressions are associated with tumor progression, tumor size, and lymph node status. In benign proliferative lesions, both HMWK and p27 expressions were helpful in differential diagnosis of borderline atypical ductal hyperplasia and DCIS. 

CXCR-4, SDF-1, p27, HMWCK, benign proliferative breast lesions, ductal carcinoma in situ, invasive ductal carcinoma, tissue microarray
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Birincil Dil en
Konular Hücre Biyolojisi, Onkoloji, Patoloji, Sağlık Bilimleri ve Hizmetleri
Bölüm Original Article

Orcid: 0000-0002-2710-127X
Yazar: Gonca ÖZGÜN (Sorumlu Yazar)
Kurum: Department of Pathology, Başkent University School of Medicine, Ankara, Turkey
Ülke: Turkey

Orcid: 0000-0003-0995-441X
Yazar: Gülen AKYOL
Kurum: Department of Pathology, Gazi University School of Medicine, Ankara, Turkey
Ülke: Turkey

Destekleyen Kurum Gazi University Scientific Research Projects Unit
Proje Numarası SBE-01/2007-104

Yayımlanma Tarihi : 4 Eylül 2019

EndNote %0 The European Research Journal Evaluation of high molecular weight cytokeratin (HMWCK), p27, C-X-C chemokine receptor type 4 (CXCR-4) and stromal cell-derived factor 1 (SDF-1) expressions related to tumor progression in breast cancer %A Gonca Özgün , Gülen Akyol %T Evaluation of high molecular weight cytokeratin (HMWCK), p27, C-X-C chemokine receptor type 4 (CXCR-4) and stromal cell-derived factor 1 (SDF-1) expressions related to tumor progression in breast cancer %D 2019 %J The European Research Journal %P -2149-3189 %V 5 %N 5 %R doi: 10.18621/eurj.423593 %U 10.18621/eurj.423593