Evaluation of serum vitamin D levels in premenopausal women with iron deficiency anemia

Yıl 2020, Cilt: 6 Sayı: 3, 232 - 237, 04.05.2020

Eray Atalay , Gökhan Bilgehan Pınar Şişman , Halil İbrahim Erdoğdu

https://doi.org/10.18621/eurj.476438

Cited By: 1

Öz

Objectives:
In recent years, many effects of
vitamin D except on bone metabolism have been discovered. Vitamin D contributes
to the correction of the anemia by acting on the erythroid precursors in the
bone marrow via Vitamin D Receptor and provides the elimination of free
radicals and prooxidant substances secondary to iron deficiency due to its
antioxidant effect in iron deficiency anemia (IDA).

Methods: A total of 97 female premenopausal
women aged 18-44 were included in the study. Fifty patients with hemoglobin
levels below 12 mg/dl and iron deficiency were classified as IDA group, and 47
subjects with hemoglobin levels of 12 mg/dl and above were classified as
control group. The demographic data and biochemical parameters of all patients
included in the study were analyzed.

Results: The vitamin D of the patient group
was found to be 7.87 ± 3.63 ng/ml and the vitamin D of the control group was
11.84 ± 6.72 ng/ml. The difference between the groups was statistically
significant. There was a positive correlation between serum vitamin D and serum
hemoglobin, hematocrit, serum MCH, serum iron level, transferrin saturation
index, ferritin.

Conclusions: In the light of the results of our study and other studies in the
literature, we think that vitamin D deficiency may be important in patients
with IDA and that vitamin D deficiency in these individuals will contribute to
the regulation of anemia due to positive effects of vitamin D on both
erythropoiesis and hepcidin in IDA are considered. However, larger studies are
needed to clarify this issue. 

Anahtar Kelimeler

Vitamin D, iron deficiency anemia, anemia

Kaynakça

• 1. Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006;290:G199-203.
• 2. Oner AF, Bay A. [Iron deficiency anemia]. Türkiye Klinikleri J Pediatr Sci 2005;1:7-15. [Article in Turkish]
• 3. Diaz-Castro J, Alferez MJ, Lopez-Aliaga I, Nestares T, Granados S, Barrionuevo M, et al. Influence of nutritional iron deficiency anemia on DNA stability and lipid peroxidation in rats. Nutrition 2008;24:1167-73.
• 4. Aslan M, Horoz M, Kocyigit A, Ozgonul S, Celik H, Celik M, et al. Lymphocyte DNA damage and oxidative stress in patients with iron deficiency anemia. Mutat Res 2006;601:144-9.
• 5. Coghetto Baccin A, Lauerman Lazzaretti L, Duarte Martins Brandao V, Manfredini V, Peralba MC, Silveira Benfato M. Oxidative stress in older patients with iron deficiency anaemia. J Nutr Health Aging 2009;13:666-70.
• 6. Hollick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancer and cardiovascular disease. Am J ClinNutr 2004; 80 (6suppl): S1678-88.
• 7. Ward LM. Vitamin D deficiency in the 21st century: a persistent problem among Canadian infants and mothers. CMAJ 2005;172:769-70.
• 8. Heaney RP. Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr 2003;78:912- 9.
• 9. Pilz S, Tomaschitz A, Drechsler C, de Boer RA. Vitamin D deficiency and heart disease. Kidney Int Suppl 2011;1:111-5.
• 10. Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effect of 1,25 dihydroxyvitaminD3 on human B cell differentiation. J Immunol 2007;179:1634-47.
• 11. Blazsek I, Farabos C, Quittet P, Labat ML, Bringuier AF, Triana BK, et al. Bone marrow stromal cell defects and 1 alpha, 25-dihydroxyvitamin D3 deficiency underlying human myeloid leukemias. Cancer Detect Prev 1996;20:31-42.
• 12. Reichel H, Koeffler HP, Norman AW. The role of the vitamin D endocrine system in health and disease. N Engl J Med 1989;320:980-91.
• 13. Norman AW. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006;147:5542-8.
• 14. Alon DB, Chaimovitz C, Dvilansky A, Lugassy G, Douvdevani A, Shany S, et al. Novel role of 1, 25 (OH)(2)D(3) in induction of erythroid progenitor cell proliferation. Exp Hematol 2002;30:403-9.
• 15. Lanzkowsky P. İron-deficiency anemia. Manual of Pediatric Hematology and Oncology 3rd ed., USA: Academic Press, 2000;33-47.
• 16. Prasad AN, Prasad C. Iron deficiency; non-hematological manifestations. Prog Food Nutr Sci 1991;15:255-83.
• 17. Ramakrishnan U, Aburto N, McCabe G, Martorell R. Multimicronutrient interventions but not vitamin A or iron interventions alone improve child growth: results of 3 meta-analyses. J Nutr 2004;134:2592-602.
• 18. Isler M, Delibas N, Guclu M, Gultekin F, Sutcu R, Bahceci M, Kosar A. Superoxide dismutase and glutathione peroxidase in erythrocytes of patients with ıron deficiency anemia: effects of different modalities. Croat Med J 2002;43 16-9.
• 19. Vural H, Erel Ö, Koçyiğit A, Sabuncu T. [Oxidative stress in erythrocytes of patients with iron deficiency anemia]. Genel Tıp Dergisi 1997;7:77-80. [Article in Turkish]
• 20. Kumerova A, Lece A, Skesters A, Silova A, Petuhovs V. Anaemia and antioxidant defence of the red blood cells. Mater Med Pol 1998;30:12-5.
• 21. Yoo JH, Maeng HY, Sun YK, Kim YA, Park DW, Park TS, et al. Oxidative status in iron-deficiency anemia. J Clin Lab Anal 2009;23:319-2.
• 22. İmazeki I, MatsuzakiJ, Tsuji K, Nishimura T. Immunomodulating effect of vitamin D3 derivaties on type-1 cellular immunity. Biomed Res 2006;27:1-9.
• 23. Modan M, Halkın H, Karasık A, Lusky A. Elevated serum uric acid: a facet of hyperinsulinemia. Diabetologia 1987;30:713-8.
• 24. Saab G, Young DO, Gincherman Y, Giles K, Norwood K, Coyne DW. Prevalence of vitamin D deficiency and the safety and effectiveness of monthly ergocalciferol in hemodialysis patients. Nephron Clin Pract 2007;105:c132-8.
• 25. Aucella F, Scalzulli RP, Gatta G, Vigilante M, Carella AM, Stallone C. Calcitriol increases burst-forming unit-erythroid proliferation in chronic renal failure. A synergistic effect with r-HuEpo. Nephron Clin Pract 2003;95:c121-7.
• 26. Perlstein TS, Pande R, Berliner N, Vanasse GJ. Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation. Blood 2011;117:2800-6.
• 27. Sim JJ, Lac PT, Liu IL, Meguerditchian SO, Kumar VA, Kujubu DA, et al. Vitamin D deficiency and anemia: a cross-sectional study. Ann Hematol 2010;89:447-52.
• 28. Lee JA, Hwang JS, Hwang IT, Kim DH, Seo J-H, Lim JS. Low vitamin D levels are associated with both iron deficiency and anemia in children and adolescents. Pediatr Hematol Oncol 2015;32:2:99-108.
• 29. Thomas CE, Guillet R, Queenan RA. Vitamin D status is inversely associated with anemia and serumerythropoietin during pregnancy. Am J Clin Nutr 2015;102:1088-95.
• 30. Meguro S, Tomita M, Katsuki T, Kato K, Oh H, Ainai A, et al. Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus. Int J Endocrinol 2011;2011:362981.
• 31. Zittermann A, Jungvogel A, Prokop S, Kuhn J, Dreier J, Fuchs U, et al. Vitamin D deficiency is an independent predictor of anemia in end-stage heart failure. Clin Res Cardiol 2011;100:781-8.
• 32. Ganz T, Nemeth E. Hepcidin and iron homeostasis. Biochim Biophys Acta 2012;1823:1434-43.
• 33. Carvalho C, Isakova T, Collerone G, et al. Hepcidin and disordered mineral metabolism in chronic kidney disease. Clin Nephrol 2011;76:90-8.
• 34. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.