Yıl 2020, Cilt 6 , Sayı 3, Sayfalar 232 - 237 2020-05-04

Evaluation of serum vitamin D levels in premenopausal women with iron deficiency anemia

Eray ATALAY [1] , Gökhan BİLGEHAN [2] , Pınar ŞİŞMAN [3] , Halil İbrahim ERDOĞDU [4]


Objectives: In recent years, many effects of vitamin D except on bone metabolism have been discovered. Vitamin D contributes to the correction of the anemia by acting on the erythroid precursors in the bone marrow via Vitamin D Receptor and provides the elimination of free radicals and prooxidant substances secondary to iron deficiency due to its antioxidant effect in iron deficiency anemia (IDA).

Methods: A total of 97 female premenopausal women aged 18-44 were included in the study. Fifty patients with hemoglobin levels below 12 mg/dl and iron deficiency were classified as IDA group, and 47 subjects with hemoglobin levels of 12 mg/dl and above were classified as control group. The demographic data and biochemical parameters of all patients included in the study were analyzed.

Results: The vitamin D of the patient group was found to be 7.87 ± 3.63 ng/ml and the vitamin D of the control group was 11.84 ± 6.72 ng/ml. The difference between the groups was statistically significant. There was a positive correlation between serum vitamin D and serum hemoglobin, hematocrit, serum MCH, serum iron level, transferrin saturation index, ferritin.

Conclusions: In the light of the results of our study and other studies in the literature, we think that vitamin D deficiency may be important in patients with IDA and that vitamin D deficiency in these individuals will contribute to the regulation of anemia due to positive effects of vitamin D on both erythropoiesis and hepcidin in IDA are considered. However, larger studies are needed to clarify this issue. 

Vitamin D, iron deficiency anemia, anemia
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Birincil Dil en
Konular Endokrinoloji ve Metabolizma, Genel ve Dahili Tıp
Bölüm Original Article
Yazarlar

Orcid: 0000-0002-9700-7019
Yazar: Eray ATALAY
Kurum: Department of Internal Medicine, Kafkas University School of Medicine, Kars, Turkey
Ülke: Turkey


Orcid: 0000-0001-8538-2340
Yazar: Gökhan BİLGEHAN
Kurum: Department of Internal Medicine, Kulu State Hospital, Konya, Turkey
Ülke: Turkey


Orcid: 0000-0002-6561-6207
Yazar: Pınar ŞİŞMAN (Sorumlu Yazar)
Kurum: Department of Endocrinology and Metabolism, Medicana Hospital, Bursa, Turkey
Ülke: Turkey


Orcid: 0000-0001-7231-7646
Yazar: Halil İbrahim ERDOĞDU
Kurum: Department of Internal Medicine, Kafkas University School of Medicine, Kars, Turkey
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 4 Mayıs 2020

EndNote %0 The European Research Journal Evaluation of serum vitamin D levels in premenopausal women with iron deficiency anemia %A Eray ATALAY , Gökhan BİLGEHAN , Pınar ŞİŞMAN , Halil İbrahim ERDOĞDU %T Evaluation of serum vitamin D levels in premenopausal women with iron deficiency anemia %D 2020 %J The European Research Journal %P -2149-3189 %V 6 %N 3 %R doi: 10.18621/eurj.476438 %U 10.18621/eurj.476438