Comparison of neuroprotective effect of isoflurane and sevoflurane on cerebral ischemia

Year 2020, Volume: 6 Issue: 5, 373 - 379, 04.09.2020

Halil Erkan Sayan , Vuslat Muslu Erdem Şefika Gülsen Korfalı

https://doi.org/10.18621/eurj.554642

Abstract

Objectives:
In this study, we aimed to evaluate the effects of isoflurane and
sevoflurane on cerebral ischemia in patients undergoing intracranial tumour
surgery by measuring protein S-100B in serum. Patients undergoing intracranial
surgery are at risk for cerebral ischemia. The presence of S100-B in serum is
an early and the most sensitive determinant of cerebral ischemia.

Methods: Twenty patients, scheduled
for elective, intracranial tumor surgery were enrolled in this prospective and randomized
study. Anaesthesia induction was performed with thiopental, fentanyl and
vecuronium. In the maintenance, isoflurane or sevoflurane was administered in a
minimum alveolar concentration of 0.8-1.2%. Peripheral blood samples were taken
at 9 different times to measure protein S-100B levels.

Results: Demographic data, heart
rate, systolic arterial pressure, mean arterial pressure and the deviations in
the end-tidal carbon dioxide were similar in the study groups (p > 0.05),
whereas diastolic arterial pressure was found to be significantly decreased in
isoflurane group after the intubation, and there was an increase in the
sevoflurane group (p < 0.05). Also there was no significant difference
between the groups regarding protein S-100B levels.

Conclusions: It was concluded that isoflurane and sevoflurane
have similar neuroprotective effects against cerebral ischemia and sevoflurane
may be a good alternative to isoflurane. 

 

Keywords

protein S-100B, intracranial tumor, inhalational anaesthetics

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