Research Article
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Year 2025, Volume: 11 Issue: 2, 420 - 426, 04.03.2025
https://doi.org/10.18621/eurj.1618895

Abstract

References

  • 1. Pollock A, St George B, Fenton M, Firkins L. Top ten research priorities relating to life after stroke. Lancet Neurol. 2012;11(3):209. doi: 10.1016/S1474-4422(12)70029-7.
  • 2. Pendlebury ST, Rothwell PM; Oxford Vascular Study. Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. Lancet Neurol. 2019;18(3):248-258. doi: 10.1016/S1474-4422(18)30442-3.
  • 3. Barbay M, Taillia H, Nédélec-Ciceri C, et al. Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit. Stroke. 2018;49(5):1141-1147. doi: 10.1161/STROKEAHA.117.018889.
  • 4. Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol. 2009;8(11):1006-1018. doi: 10.1016/S1474-4422(09)70236-4.
  • 5. Rost NS, Brodtmann A, Pase MP, et al. Post-Stroke Cognitive Impairment and Dementia. Circ Res. 2022;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951.
  • 6. Aam S, Einstad MS, Munthe-Kaas R, et al. Post-stroke Cognitive Impairment-Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study. Front Neurol. 2020;11:699. doi: 10.3389/fneur.2020.00699.
  • 7. Biesbroek JM, Weaver NA, Biessels GJ. Lesion location and cognitive impact of cerebral small vessel disease. Clin Sci (Lond). 2017;131(8):715-728. doi: 10.1042/CS20160452.
  • 8. Karnath HO, Rennig J. Investigating structure and function in the healthy human brain: validity of acute versus chronic lesion-symptom mapping. Brain Struct Funct. 2017;222(5):2059-2070. doi: 10.1007/s00429-016-1325-7.
  • 9. Barbay M, Taillia H, Nédélec-Ciceri C, et al. Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit. Stroke. 2018;49(5):1141-1147. doi: 10.1161/STROKEAHA.117.018889.
  • 10. Munsch F, Sagnier S, Asselineau J, et al. Stroke Location Is an Independent Predictor of Cognitive Outcome. Stroke. 2016;47(1):66-73. doi: 10.1161/STROKEAHA.115.011242.
  • 11. Weaver NA, Kuijf HJ, Aben HP, et al. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. Lancet Neurol. 2021;20(6):448-459. doi: 10.1016/S1474-4422(21)00060-0.
  • 12. Weaver NA, Zhao L, Biesbroek JM, et al. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimers Dement (Amst). 2019;11:310-326. doi: 10.1016/j.dadm.2019.02.007.
  • 13. Karnath HO, Sperber C, Rorden C. Mapping human brain lesions and their functional consequences. Neuroimage. 2018;165:180-189. doi: 10.1016/j.neuroimage.2017.10.028.
  • 14. Howard VJ, Cushman M, Pulley L, et al. The reasons for geographic and racial differences in stroke study: objectives and design. Neuroepidemiology. 2005;25(3):135-143. doi: 10.1159/000086678.
  • 15. Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142. doi: 10.1186/s12974-019-1516-2.
  • 16. Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374. doi: 10.1001/jama.2010.1361.
  • 17. Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012;172(10):799-809. doi: 10.1001/archinternmed.2012.402.
  • 18. Feigin VL, Forouzanfar MH, Krishnamurthi R, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383(9913):245-254. doi: 10.1016/s0140-6736(13)61953-4.
  • 19. Selmer C, Olesen JB, Hansen ML, et al. The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. BMJ. 2012;345:e7895. doi: 10.1136/bmj.e7895.

Cognitive dysfunction after ischemic stroke

Year 2025, Volume: 11 Issue: 2, 420 - 426, 04.03.2025
https://doi.org/10.18621/eurj.1618895

Abstract

Objectives: One of the most important and common consequences of ischemic stroke is the cognitive impairment observed after stroke. This study aimed to investigate the role of strategic stroke among post-stroke cognitive impairment using the Montreal Cognitive Assessment Scale (MOCA).

Methods: This study was planned as a prospective cross-sectional study. Patients admitted between 3 and 12 months after stroke were included in the study. Patients who had a stroke at least 3 months ago, who had not been admitted for a year after the stroke, and who gave consent to participate in the study were considered as inclusion criteria.

Results: This study included 45 (44.1%) females and 57 (55.9%) males. When evaluated in terms of comorbidity, the frequency of hyperlipidemia was found to be significantly higher in the cognitively impaired group (46.5% vs. 25.4%, P=0.027). Thyroid stimulating hormone (TSH) levels were found to be lower in the Cognitive Impairment Group (0.93 μIU/mL vs. 1.03 μIU/mL, P=0.021). Considering the finding rates and significance level of lesion sites between the groups, the strategic infarction rate was found to be significantly higher in the cognitively impaired group (62.8% vs. 33.9%, P=0.004). In cognitive tests, the cognitive impairment group showed significantly lower performance in all areas (P<0.05).

Conclusions: It should be kept in mind that the MOCA scale can be a good evaluation scale in detecting patients with cognitive impairment after ischemic stroke.

Ethical Statement

This study was approved by the Adana City Training and Research Hospital Clinical Research Ethics Committee (Decision date: 31.08.2023 and no: 2803).

References

  • 1. Pollock A, St George B, Fenton M, Firkins L. Top ten research priorities relating to life after stroke. Lancet Neurol. 2012;11(3):209. doi: 10.1016/S1474-4422(12)70029-7.
  • 2. Pendlebury ST, Rothwell PM; Oxford Vascular Study. Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study. Lancet Neurol. 2019;18(3):248-258. doi: 10.1016/S1474-4422(18)30442-3.
  • 3. Barbay M, Taillia H, Nédélec-Ciceri C, et al. Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit. Stroke. 2018;49(5):1141-1147. doi: 10.1161/STROKEAHA.117.018889.
  • 4. Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. Lancet Neurol. 2009;8(11):1006-1018. doi: 10.1016/S1474-4422(09)70236-4.
  • 5. Rost NS, Brodtmann A, Pase MP, et al. Post-Stroke Cognitive Impairment and Dementia. Circ Res. 2022;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951.
  • 6. Aam S, Einstad MS, Munthe-Kaas R, et al. Post-stroke Cognitive Impairment-Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study. Front Neurol. 2020;11:699. doi: 10.3389/fneur.2020.00699.
  • 7. Biesbroek JM, Weaver NA, Biessels GJ. Lesion location and cognitive impact of cerebral small vessel disease. Clin Sci (Lond). 2017;131(8):715-728. doi: 10.1042/CS20160452.
  • 8. Karnath HO, Rennig J. Investigating structure and function in the healthy human brain: validity of acute versus chronic lesion-symptom mapping. Brain Struct Funct. 2017;222(5):2059-2070. doi: 10.1007/s00429-016-1325-7.
  • 9. Barbay M, Taillia H, Nédélec-Ciceri C, et al. Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit. Stroke. 2018;49(5):1141-1147. doi: 10.1161/STROKEAHA.117.018889.
  • 10. Munsch F, Sagnier S, Asselineau J, et al. Stroke Location Is an Independent Predictor of Cognitive Outcome. Stroke. 2016;47(1):66-73. doi: 10.1161/STROKEAHA.115.011242.
  • 11. Weaver NA, Kuijf HJ, Aben HP, et al. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts. Lancet Neurol. 2021;20(6):448-459. doi: 10.1016/S1474-4422(21)00060-0.
  • 12. Weaver NA, Zhao L, Biesbroek JM, et al. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimers Dement (Amst). 2019;11:310-326. doi: 10.1016/j.dadm.2019.02.007.
  • 13. Karnath HO, Sperber C, Rorden C. Mapping human brain lesions and their functional consequences. Neuroimage. 2018;165:180-189. doi: 10.1016/j.neuroimage.2017.10.028.
  • 14. Howard VJ, Cushman M, Pulley L, et al. The reasons for geographic and racial differences in stroke study: objectives and design. Neuroepidemiology. 2005;25(3):135-143. doi: 10.1159/000086678.
  • 15. Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA. Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation. 2019;16(1):142. doi: 10.1186/s12974-019-1516-2.
  • 16. Rodondi N, den Elzen WP, Bauer DC, et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA. 2010;304(12):1365-1374. doi: 10.1001/jama.2010.1361.
  • 17. Collet TH, Gussekloo J, Bauer DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012;172(10):799-809. doi: 10.1001/archinternmed.2012.402.
  • 18. Feigin VL, Forouzanfar MH, Krishnamurthi R, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383(9913):245-254. doi: 10.1016/s0140-6736(13)61953-4.
  • 19. Selmer C, Olesen JB, Hansen ML, et al. The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. BMJ. 2012;345:e7895. doi: 10.1136/bmj.e7895.
There are 19 citations in total.

Details

Primary Language English
Subjects Neurology and Neuromuscular Diseases
Journal Section Original Articles
Authors

Derya Ozdogru 0000-0003-3567-1317

Miray Erdem 0000-0001-8369-7816

Early Pub Date February 27, 2025
Publication Date March 4, 2025
Submission Date January 13, 2025
Acceptance Date February 26, 2025
Published in Issue Year 2025 Volume: 11 Issue: 2

Cite

AMA Ozdogru D, Erdem M. Cognitive dysfunction after ischemic stroke. Eur Res J. March 2025;11(2):420-426. doi:10.18621/eurj.1618895

e-ISSN: 2149-3189 


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