Yıl 2021, Cilt 11 , Sayı 1, Sayfalar 21 - 26 2021-05-03

Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model
Doğal Yaşlanma Modelinde Egzersiz ve Kalori Kısıtlamasının Beyin ve Testiste Etkileri

Umay HAKGÜDER [1] , Ünsal Veli ÜSTÜNDAĞ [2] , Burçin Alev TÜZÜNER [3] , Nevin GENÇ [4] , Hazal İPEKÇİ [5] , Reyhan ÖZÇELİK [6] , Tuğba TUNALI-AKBAY [7] , Göksel ŞENER [8] , Ayşen YARAT [9] , Ebru EMEKLİ ALTURFAN [10]


The aim of our study was to examine the effects of exercise and cal-orie restriction on various tissue damage and antioxidant parame-ters in the brain and testis of rats in a natural aging model. For this purpose, male Sprague-Dawley rats were the control group (C), the elderly (A), the elderly with calorie restriction (ACR), the elderly who were exercised (AE) and the elderly who were exercised with calorie restriction (ACRE), they were divided into 5 groups. The con-trol group was composed of three-month-old animals. The other group consisted of 15-month-old rats. Exercise and calorie restric-tion were applied for 6 weeks. At the end of the experiment, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels and superoxide dismutase (SOD), catalase (CAT), glutathione-S-trans-ferase (GST) and tissue factor (TF) were determined in brain and testicular tissues homogenates. As a result of the study, the A group’s brain and testis LPO, NO levels and TF activity increased, GSH levels and SOD, CAT and GST activities decreased, when com-pared to the C group. As a result of our study, an increase in oxidant damage was observed with TF activity in the brain and testis in the natural aging model, and positive effects of exercise and calorie restriction on the antioxidant levels in the brain were determined, especially in aging.

Amacımız doğal yaşlanma modelinde egzersiz ve kalori kısıtlama-sının sıçanlarda beyin ve testiste çeşitli doku hasarı ve antioksidan parametreler üzerine etkilerinin incelenmesidir. Bu amaçla Spragu-e-Dawley sıçanlar kontrol (K), yaşlı (Y), kalori kısıtlaması uygulanan yaşlı (YKK), egzersiz uygulanan yaşlı (YE) ve kalori kısıtlaması ile egzersiz uygulanan yaşlı (YKKE) olmak üzere 5 gruba ayrıldı. Kont-rol grubu üç aylık genç hayvanlardan oluşturuldu. Diğer gruplar 15 aylık sıçanlardan oluşturuldu. Egzersiz ve kalori kısıtlaması 6 hafta boyunca uygulandı. Deney sonunda beyin ve testis dokuları homojenatlarında lipit peroksidasyon (LPO), nitrik oksit (NO), glu-tatyon (GSH) düzeyleri ile süperoksit dismutaz (SOD), katalaz (CAT), glutatyon-S-transferaz (GST) ve doku faktörü (DF) aktiviteleri tayin edildi. Çalışma sonucunda K grubu ile kıyaslandığında Y grubunda, beyin ve testis LPO, NO düzeyleri ve DF aktivitelerinin arttığı, GSH düzeyleri ile SOD, CAT ve GST aktivitelerinin ise azaldığı gözlendi. Doğal yaşlanma modelinde beyin ve testiste DF aktivitesi ile be-raber oksidan hasarda artış gözlenmiş olup, özellikle yaşlanmada egzersiz ve kalori kısıtlamasının beyinde antioksidan düzeyleri üze-rinde olumlu etkileri belirlenmiştir.

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Birincil Dil en
Konular Tıp
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0002-0683-4335
Yazar: Umay HAKGÜDER
Kurum: Department of Biochemistry, Faculty of Dentistry, Marmara University, Maltepe, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0003-0804-1475
Yazar: Ünsal Veli ÜSTÜNDAĞ
Kurum: Department of Biochemistry, Medical Faculty, Istanbul Medipol University, Kavacık, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0001-5122-4977
Yazar: Burçin Alev TÜZÜNER
Kurum: Department of Biochemistry, Faculty of Dentistry, Gelişim University, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0003-2143-0088
Yazar: Nevin GENÇ
Kurum: Department of Medical Biochemistry, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0003-1193-168X
Yazar: Hazal İPEKÇİ
Kurum: Department of Biochemistry, Faculty of Dentistry, Marmara University, Maltepe, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0002-1453-464X
Yazar: Reyhan ÖZÇELİK
Kurum: Department of Pharmacology, Faculty of Pharmacy, Marmara University, Haydarpaşa, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0002-2091-9298
Yazar: Tuğba TUNALI-AKBAY
Kurum: MARMARA UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-7444-6193
Yazar: Göksel ŞENER
Kurum: FENERBAHÇE ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0002-8258-6118
Yazar: Ayşen YARAT
Kurum: MARMARA UNIVERSITY
Ülke: Turkey


Orcid: 0000-0003-2419-8587
Yazar: Ebru EMEKLİ ALTURFAN (Sorumlu Yazar)
Kurum: MARMARA UNIVERSITY
Ülke: Turkey


Destekleyen Kurum Marmara University Scientific Research and Project Commission
Proje Numarası Project No: SAG-C-YLP-131217-0662.
Tarihler

Başvuru Tarihi : 18 Mart 2021
Kabul Tarihi : 26 Mart 2021
Yayımlanma Tarihi : 3 Mayıs 2021

Bibtex @araştırma makalesi { experimed899430, journal = {Experimed}, issn = {}, eissn = {2667-5846}, address = {}, publisher = {İstanbul Üniversitesi}, year = {2021}, volume = {11}, pages = {21 - 26}, doi = {10.26650/experimed.2021.899430}, title = {Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model}, key = {cite}, author = {Hakgüder, Umay and Üstündağ, Ünsal Veli and Tüzüner, Burçin Alev and Genç, Nevin and İpekçi, Hazal and Özçelik, Reyhan and Tunalı-akbay, Tuğba and Şener, Göksel and Yarat, Ayşen and Emekli Alturfan, Ebru} }
APA Hakgüder, U , Üstündağ, Ü , Tüzüner, B , Genç, N , İpekçi, H , Özçelik, R , Tunalı-akbay, T , Şener, G , Yarat, A , Emekli Alturfan, E . (2021). Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model . Experimed , 11 (1) , 21-26 . DOI: 10.26650/experimed.2021.899430
MLA Hakgüder, U , Üstündağ, Ü , Tüzüner, B , Genç, N , İpekçi, H , Özçelik, R , Tunalı-akbay, T , Şener, G , Yarat, A , Emekli Alturfan, E . "Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model" . Experimed 11 (2021 ): 21-26 <https://dergipark.org.tr/tr/pub/experimed/issue/62231/899430>
Chicago Hakgüder, U , Üstündağ, Ü , Tüzüner, B , Genç, N , İpekçi, H , Özçelik, R , Tunalı-akbay, T , Şener, G , Yarat, A , Emekli Alturfan, E . "Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model". Experimed 11 (2021 ): 21-26
RIS TY - JOUR T1 - Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model AU - Umay Hakgüder , Ünsal Veli Üstündağ , Burçin Alev Tüzüner , Nevin Genç , Hazal İpekçi , Reyhan Özçelik , Tuğba Tunalı-akbay , Göksel Şener , Ayşen Yarat , Ebru Emekli Alturfan Y1 - 2021 PY - 2021 N1 - doi: 10.26650/experimed.2021.899430 DO - 10.26650/experimed.2021.899430 T2 - Experimed JF - Journal JO - JOR SP - 21 EP - 26 VL - 11 IS - 1 SN - -2667-5846 M3 - doi: 10.26650/experimed.2021.899430 UR - https://doi.org/10.26650/experimed.2021.899430 Y2 - 2021 ER -
EndNote %0 Experimed Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model %A Umay Hakgüder , Ünsal Veli Üstündağ , Burçin Alev Tüzüner , Nevin Genç , Hazal İpekçi , Reyhan Özçelik , Tuğba Tunalı-akbay , Göksel Şener , Ayşen Yarat , Ebru Emekli Alturfan %T Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model %D 2021 %J Experimed %P -2667-5846 %V 11 %N 1 %R doi: 10.26650/experimed.2021.899430 %U 10.26650/experimed.2021.899430
ISNAD Hakgüder, Umay , Üstündağ, Ünsal Veli , Tüzüner, Burçin Alev , Genç, Nevin , İpekçi, Hazal , Özçelik, Reyhan , Tunalı-akbay, Tuğba , Şener, Göksel , Yarat, Ayşen , Emekli Alturfan, Ebru . "Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model". Experimed 11 / 1 (Mayıs 2021): 21-26 . https://doi.org/10.26650/experimed.2021.899430
AMA Hakgüder U , Üstündağ Ü , Tüzüner B , Genç N , İpekçi H , Özçelik R , Tunalı-akbay T , Şener G , Yarat A , Emekli Alturfan E . Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model. Experimed. 2021; 11(1): 21-26.
Vancouver Hakgüder U , Üstündağ Ü , Tüzüner B , Genç N , İpekçi H , Özçelik R , Tunalı-akbay T , Şener G , Yarat A , Emekli Alturfan E . Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model. Experimed. 2021; 11(1): 21-26.
IEEE U. Hakgüder , Ü. Üstündağ , B. Tüzüner , N. Genç , H. İpekçi , R. Özçelik , T. Tunalı-akbay , G. Şener , A. Yarat ve E. Emekli Alturfan , "Effects of Exercise and Calorie Restriction on Brain and Testis in Natural Aging Model", Experimed, c. 11, sayı. 1, ss. 21-26, May. 2021, doi:10.26650/experimed.2021.899430