An Important Adipokine: Isthmin-1
Abstract
The presence of isthmin-1 in different body compartments reveals its significance in metabolism, cell proliferation, endothelial permeability, angiogenesis and immunity. Studies have categorized isthmin-1 as an adipokine with insulin-like behavior that uptakes glucose by the adipocytes and inhibits liver steatosis through a not identified tyrosine kinase receptor, that it is distinct from insulin receptor. Additionally, this adipokine demonstrates important functions in regulating organs development and homeostasis. This review aims to summarize the informations of isthmin-1 protein mainly its functions on glucose and lipid metabolisms.
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References
- Pera EM, Kim JI, Martinez SL, et al. Isthmin is a novel secreted protein expressed as part of the Fgf-8 synexpression group in the Xenopus midbrain-hindbrain organizer. Mech Dev. 2002;116(1-2):169-172.
- Hu M, Zhang X, Hu C, Teng T, Tang QZ. A brief overview about the adipokine: Isthmin-1. Front Cardiovasc Med. 2022;9:939757.
- Shakhawat HM, Hazrat Z, Zhou Z. Isthmin-A Multifaceted Protein Family. Cells. 2022;12(1):17.
- Martinez C, González-Ramírez J, Marín ME, et al. Isthmin 2 is decreased in preeclampsia and highly expressed in choriocarcinoma. Heliyon. 2020;6(10):e05096.
- Xiang W, Ke Z, Zhang Y, et al. Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice. J Cell Mol Med. 2011;15(2):359-374.
- Liang JY, Wei HJ, Tang YY. Isthmin: A multifunctional secretion protein. Cytokine. 2024;173:156423.
- Hendershot LM. The ER function BiP is a master regulator of ER function. Mt Sinai J Med. 2004;71(5):289-297.
- Strange PG. Agonist binding, agonist affinity and agonist efficacy at G protein-coupled receptors. Br J Pharmacol. 2008;153(7):1353-1363.
- Zhang Y, Chen M, Venugopal S, et al. Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state. Cell Death Dis. 2011;2(5):e153.
- Li C, Zhong S, Ni S, Liu Z, Zhang S, Ji G. Zebrafish Ism1 is a novel antiviral factor that positively regulates antiviral immune responses. Dev Comp Immunol. 2021;125:104210.