Obez ve obez olmayan çocuklarda inflamatuar hematolojik parametrelerin karşılaştırılması

Yıl 2023, Cilt: 8 Sayı: 1, 24 - 29, 07.02.2023

Fatma Demir Yenigurbuz Elif Söbü Berkin Berk Akbeyaz

https://doi.org/10.22391/fppc.1197997

Öz

Giriş: Obezite, tüm dünyada giderek artan bir sağlık sorunudur ve insülin direnci (İD), hipertansiyon, ateroskleroz ve bazı kanserlerle ilgili önemli bir inflamatuar faktöre sahiptir. Bu çalışma, çocukluk çağı obezitesindeki inflamatuar hematolojik parametreleri değerlendirmeyi amaçlamaktadır.

Yöntem: Altmış dört obez ve 50 normal kilolu olgu çalışmaya dahil edildi. Hastaların fizik muayene özellikleri ve laboratuvar verileri dosyalarından geriye dönük olarak değerlendirildi. Gruplar arasında laboratuvar testleri, hematolojik parametreler, cinsiyet dağılımı karşılaştırıldı. Obez grupta insülin direnci (HOMA-IR) için Homeostasis modeli değerlendirmesi ile diğer laboratuvar parametreleri arasındaki korelasyonlar incelendi.

Bulgular: Obez grubun lökosit, nötrofil, monosit, lenfosit, trombosit ve MPV değerleri kontrol grubuna göre istatistiksel olarak yüksek bulundu (p: 0,006, p:0,015, p:0,014, p:0,001, p<0,001). Nötrofil/Lenfosit oranı (N/L), Monosit/Lenfosit oranı (M/L) ve Trombosit/Lenfosit oranı (T/L) açısından iki grup arasında istatistiksel olarak anlamlı fark yoktu (p: 0,642, p:0,989, 0,982). Ayrıca Homa IR ve yaş, VKİ, Nötrofil, Lenfosit, Monosit, Trombosit, Nötrofil/Lenfosit, Monosit/Lenfosit ve Trombosit/Lenfosit değerleri arasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır.

Sonuç: Çalışmamızda obez adolesan grubunun N/L, P/L, M/L değerleri kontrol grubu ile benzerdi. Bununla birlikte, obez grubundaki lökosit, nötrofil, monosit, lenfosit, trombosit ve MPV değerleri, istatistiksel olarak kontrol grubundan daha yüksekti. Ancak bu bulgular, HOMA-IR'den bağımsız olarak obezite ve inflamasyon arasında bir ilişkiye işaret etmektedir.

Anahtar kelimeler: obezite, çocuk, inflamasyon, hematolojik parametreler

Anahtar Kelimeler

obezite, çocuk, inflamasyon, hematolojik parametreler

The comparison of inflammatory hematological parameters in obese and non-obese children

Öz

Introduction: Obesity is an increasing health problem in the whole world, and it has an important inflammatory component related to the insulin resistance (IR), hypertension, atherosclerosis and some cancers. This study aims to evaluate the inflammatory hematological parameters in childhood obesity.

Methods: Sixty-four obese and 50 normal weight cases were included in the study. The physical examination features and laboratory data of the patients were evaluated retrospectively from the patient’s files. Laboratory tests, hematological parameters, gender were compared between the groups. Correlations between Homeostasis model evaluation for insulin resistance (HOMA-IR) and other laboratory parameters in the obese group were examined.

Results: The leukocyte, neutrophile, monocyte, lymphocyte, thrombocyte and MPV values of the obese group were found to be statistically higher than the control group (p: 0.006, p:0.015, p:0.014, p:0.001, p<0.001). There was no statistically significant difference between the two groups for Neutrophile/Lymphocyte ratio (NLR), Monocyte/Lymphocyte ratio (MLR) and Platelet/Lymphocyte ratio (PLR) (p:0.642, p:0.989, 0.982). Also, there was no statistically significant correlation between Homa IR and age, BMI, Neutrophil, Lymphocyte, Monocyte, Thrombocyte, Neutrophil/Lymphocyte, Monocyte/Lymphocyte and Thrombocyte/Lymphocyte values.

Conclusion: The current study showed that there was no significant difference between obese and controls in terms of NLR, PLR, and MLR values. However, the leukocyte, neutrophile, monocyte, lymphocyte, thrombocyte and MPV values were statistically higher in obese group than controls. Nevertheless, these findings can point relation between obesity and inflammation.

Keywords: obesity, children, inflammation, hematological parameters

Anahtar Kelimeler

obesity, children, inflammation, hematological parameters

Kaynakça

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