Effect of Additional Prebiotics on Glycemia and Lipid Profile in Individuals with Type 2 Diabetes
Abstract
This study was conducted to determine the effect of prebiotic fiber intake on glycemia and lipemia in individuals with Type 2 Diabetes Mellitus (Type 2 DM). Over a 8-week period, 14 individuals with Type 2 DM between the ages of 20-50 with a Body Mass Index (BMI) above 25 kg/m² were randomly assigned to either an intervention group, in which participants were given additional prebiotic fiber with diabetic diet (n = 8, consuming 10 g/d of oligofructose-enriched inulin to diabetic diet) or to a control group, in which participants were given only with a diabetic diet (n = 6, consuming only diabetic diet). Fasting Plasma Glucose (FPG), fasting insulin, insulin resistance (HOMA-IR), glycosylated hemoglobin (HbA1c), Triglyceride (TG), Total Cholesterol (Total-C), High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C) and Very Low-Density Lipoprotein Cholesterol (VLDL-C) values were measured at the beginning and end of the study. There was no significant difference between the initial and last measurements in HbA1c, fasting insulin, HOMA-IR, and HDL-C values only in the diabetic diet group (p>0.05); whereas FPG, TG, Total-C, LDL-C, and VLDL-C levels decreased (p<0.05). In the group that received additional prebiotics in the diet, the FPG, HbA1c, TG, Total-C, VLDL-C, and LDL-C levels decreased significantly (p<0.05) at the end of the study compared to the beginning; HDL-C (p<0.05) was elevated. Prebiotics can be used as a new option in the treatment of many metabolic diseases, especially diabetes. Prebiotics will make a positive contribution to metabolic markers by changing the composition of the microbiota.
Keywords
gycemic control, lipemia, prebiotic, Type 2 diabetes
Ethical Statement
The study has been approved by the ethics committee of Gazi University (Decision No: 14.06.2021 / 578).
Thanks
The authors would like to thank Gazi University Academic Writing Application and Research Center for proofreading the article.
References
- Baigent, C., Keech, A., Kearney, P. M., Blackwell, L., Buck, G., Pollicino, C., Kirby, A., Sourjina, T., Peto, R., Collins, R., Simes, R., & Cholesterol Treatment Trialists, C. (2005). Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet, 366(9493), 1267-1278. https://doi.org/10.1016/S0140-6736(05)67394-1
- Birkeland, E., Gharagozlian, S., Gulseth, H. L., Birkeland, K. I., Hartmann, B., Holst, J. J., Holst, R., & Aas, A. M. (2021). Effects of prebiotics on postprandial GLP-1, GLP-2 and glucose regulation in patients with type 2 diabetes: A randomised, double-blind, placebo-controlled crossover trial. Diabetic Medicine, 38(10), e14657. https://doi.org/10.1111/dme.14657
- Brighenti, F. (2007). Dietary fructans and serum triacylglycerols: a meta-analysis of randomized controlled trials. The Journal of Nutrition, 137(11 Suppl), 2552S-2556S. https://doi.org/10.1093/jn/137.11.2552S
- Cani, P. D., Lecourt, E., Dewulf, E. M., Sohet, F. M., Pachikian, B. D., Naslain, D., De Backer, F., Neyrinck, A. M., & Delzenne, N. M. (2009). Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. The American Journal of Clinical Nutrition, 90(5), 1236-1243. https://doi.org/10.3945/ajcn.2009.28095
- Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019). Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods, 8(3). https://doi.org/10.3390/foods8030092
- Dehghan, P., Farhangi, M. A., Tavakoli, F., Aliasgarzadeh, A., & Akbari, A. M. (2016). Impact of prebiotic supplementation on T-cell subsets and their related cytokines, anthropometric features and blood pressure in patients with type 2 diabetes mellitus: A randomized placebo-controlled Trial. Complementary Therapies in Medicine, 24, 96-102. https://doi.org/10.1016/j.ctim.2015.12.010
- Dehghan, P., Pourghassem Gargari, B., & Asghari Jafar-abadi, M. (2014). Oligofructose-enriched inulin improves some inflammatory markers and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized controlled clinical trial. Nutrition, 30(4), 418-423. https://doi.org/10.1016/j.nut.2013.09.005
- ElSayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D., Johnson, E. L., Kahan, S., Khunti, K., Leon, J., Lyons, S. K., Perry, M. L., Prahalad, P., Pratley, R. E., Seley, J. J., Stanton, R. C., . . . on behalf of the American Diabetes, A. (2023). 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes-2023. Diabetes Care, 46(Supple 1), S68-S96. https://doi.org/10.2337/dc23-S005
- Gholizadeh, P., Mahallei, M., Pormohammad, A., Varshochi, M., Ganbarov, K., Zeinalzadeh, E., Yousefi, B., Bastami, M., Tanomand, A., Mahmood, S. S., Yousefi, M., Asgharzadeh, M., & Kafil, H. S. (2019). Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease. Microbial Pathogenesis, 127, 48-55. https://doi.org/10.1016/j.micpath.2018.11.031
- Gurung, M., Li, Z., You, H., Rodrigues, R., Jump, D. B., Morgun, A., & Shulzhenko, N. (2020). Role of gut microbiota in type 2 diabetes pathophysiology. eBioMedicine, 51, 102590. https://doi.org/10.1016/j.ebiom.2019.11.051