Hypericum perforatum Releasing From Silver Sulphadiozine Loaded Sodium Alginate Membranes
Abstract
This study presents that the controlled release of Hypericum perforatum (HP) from biofilm formation of sodium alginate (NaAlg). Its oil was incorporated in sodium alginate biofilm as a potential therapeutic agent. HP belongs from the family of Hypericaceae. HP is traditionally used for wound healing in Turkey and has medical importance. In addition, bacterial resistance of HP was investigated for against Staphylococcus aureus. Silver Sulfadiazine (SSD) was added in different concentration (0.5-2.0 w/v) to prepare the antibacterial biofilms. The addition of antibiotics and HP into the biofilm will ensure the delivery of all the necessary substances locally in the wound healing process. Biofilms were prepared by solvent casting method in different oil concentration (0.25-2.0 % v/v). The surface properties of biofilms were investigated by using Scanning Electron Microscopy (SEM), drug release profiles were studied at pH 5.5 and bacterial resistance of HP was investigated for against Staphylococcus aureus. As a result of our study, the new generation hydrogel wound dressing will, heal wounds effectively and quickly especially protecting the burns from microorganisms.
Keywords
Hypericum Perforatum,, hydrogel,, controlled release
Supporting Institution
Gazi University Scientific Research Foundation
Project Number
65/2018-01
Thanks
We are grateful to the Gazi University Scientific Research Foundation (65/2018-01) for support of this study. Gazi University Photonic Application and Research Center, Gazi University Life Sciences Research and Application Center and METU Central Laboratory for their services in finalizing some necessary analyses in this study.
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