Histopathological Effect of Bendiocarb on Small Intestine Tissues of Rats: Role of Vitamins C and E

Year 2019, Volume: 32 Issue: 2, 402 - 407, 01.06.2019

Fatma Gokce Apaydın , Hatice Baş , Suna Kalender , Caglar Adıgüzel , Yusuf Kalender

https://izlik.org/JA74DK79KG

Abstract

Bendiocarb is a carbamate insecticide which causes general toxic effects on mammalian. This study aimed to examine the possible ameliorative roles vitamins E and C and their combination against effect of bendiocarb small intestine toxicity in rats. For this purpose, forty-eight adult albino male rats were divided like: vitamin E, control, vitamin C, vitamins (C and E), bendiocarb, bendiocarb+vitamin E, bendiocarb+vitamin C, and bendiocarb+vitamin C+vitamin E groups. After four weeks of treatment small intestine tissues were examined for histopathological alterations. Bendiocarb induced toxicity on small intestine tissues, vitamins had not protective effects of this toxicity

Keywords

Bendiocarb , Vitamin C , Vitamin E , Small intestine , Histopathology

References

• [1] Jardim, A.N.O., Brito, A.P., Donkersgoed, G., Boon, P.E., and Caldasa, E.D., “Dietary cumulative acute risk assessment of organophosphorus, carbamates and pyrethroids insecticides for the Brazilian population”, Food Chem. Toxicol. 112: 108-117, (2018).
• [2] Hayes, W.J., Laws, E.R., Handbook of Pesticide Toxicology, Academic Press, New York. p. 303. (1991).
• [3] Siqueira, A., Rodrigues, K.B.A., Gonçalves-Júnior, V., Calefi, A.S., Fukushima, A.R., Cuevas, S.E.C., Spinosa,H.S., and Maiorka, P.C., “Exhumation of Wistar rats experimentally exposed to the carbamate pesticides aldicarb and carbofuran: A pathological and toxicological study”, Exp. Toxicol. Pathol. 68: 307–314, (2016).
• [4] Capcarova, M., Petrovova, E., Flesarova, S., Dankova, M., Massanyi, P., and Danko, J., “Bendiocarbamate induced alterations in selected parameters of rabbit homeostasis after experimental peroral administration”, Pestic. Biochem. Physiol. 8: 213–218, (2010).
• [5] Petrovova, E., Massanyi, P., Capcarova, M., Zivcak J., and Stodola, L., “Structural alterations in rabbit spleen after bendiocarb administration”, J. Environ. Sci. Health, Part B 46: 788–792, (2011).
• [6] Flesarova, S., Lukac, N., Danko, J., and Massanyi, P., Bendiocarbamate induced structural alterations in rabbit thymus after experimental peroral administration”, J. Environ. Sci. Heal. Part B. 42: 329–334, (2007).
• [7] Smulders, C.J., Bueters, T.J., Van Kleef, R.G., and Vijverberg, H.P., “Selective effects of carbamate pesticides on rat neuronal nicotinic acetylcholine receptors and rat brain acetylcholinesterase”, Toxicol. Appl. Pharmacol. 193: 139–146 (2003).
• [8] Jokanovic´, M., “Medical treatment of acute poisoning with organophosphorus and carbamate pesticides” Toxicol. Lett. 190: 107–115 (2009).
• [9] Apaydın, F.G., Bas, H., Kalender, S., and Kalender, Y., “Bendiocarb induced histopathological and biochemical alterations inrat liver and preventive role of vitamins C and E”, Environ. Toxicol. Pharmacol. 49: 148–155, (2017).
• [10] Uzun, F.G., Kalender, Y., “Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin”, Food Chem. Toxicol. 55: 549-556, (2013).
• [11] El-Demerdash, F., “Antioxidant effect of vitamin E and selenium on lipid peroxidation, enzyme activities and biochemical parameters in rats exposed to aluminium” J.Trace Elem. Med.. Biol. 18: 113-121 (2004).
• [12] Kalender, S., Apaydın, F.G., Uzunhisarcıklı, M., and Aslanturk, A., “Protective Role of Sodium Selenite and Vitamin E Against Rat Erythrocytes Induced by Mercury Chloride”, GU J. Sci. 27(4): 1123-112 (2014).
• [13] Aslanturk, A., Kalender, S., Uzunhisarcikli, M., and Kalender, Y., “Effects of methidathion on antioxidant enzyme activities and malondialdehyde level in midgut tissues of Lymantria dispar (Lepidoptera) larvae”, J. Entomol. Res. Soc. 13: 27-38, (2011).
• [14] Buyukguzel, E., Kalender, Y., “Penicillin-induced oxidative stress: effects on antioxidative response of midgut tissues in larval instars of G. mellonella”, J. Econ. Entomol. 100 (5): 1533-1541, (2007).
• [15] Shirpoor, A., Barmaki, H., Ansari, M.K., lkhanizadeh, B., and Barmaki, H., “Protective effect of vitamin E against ethanol-induced small intestine damage in rats” Biomed. Pharmacother. 78: 150–155 (2016).
• [16] Baş, H., Kalender, S., Karaboduk, H., and Apaydın, FG., “The effects on antioxidant enzyme systems in rat brain tissues of lead nitrate and mercury chloride”, GU J. Sci. 28(2): 169-174, (2015).
• [17] Demir, F., Uzun, F.G., Durak, D., Kalender, Y., “Subacute chlorpyrifos-induced oxidative stress in rat erythrocytes and the protective effects of catechin and quercetin”, Pestic. Biochem. Physiol. 99: 77-81 (2011). [18] Mezouar, D., Merzouk, H., Merzouk, A.S., Merzouk, S.A., Belarbi, B., Narce, M., “In vitro effects of vitamins C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell function and redox status in type 1 diabetic pregnant women”, Placenta, 42:114-121, (2016).
• [19] Chappell, L.C., Seed, P.T., Kelly, F.J., Briley, A., Hunt, B.J., Charnock-Jones, S., Mallet, A., Poston, L., “Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function”, Am. J. Obstet. Gynecol. 187: 777-784, (2002).