INVESTIGATION OF ANTIMICROBIAL EFFECTS AGAINST SOME MICROORGANISMS OF ALOE VERA AND NERIUM OLEANDER ALSO EXAMINATION OF THE EFFECTS ON THE XANTHINE OXIDASE ACTIVITY IN LIVER TISSUE TREATED WITH CYCLOSPORIN

Abstract

ABSTRACT

In this study, the antimicrobial effect of water, alcohol, choloroform extracts of aloe vera and nerium oleander were investigated on ten different strains of bacteria and yeast. Aloe vera has an antimicrobial effect more than nerium oleander. Xanthine oxidase activity of both control tissue and liver tissue treated with cyclosporin and then, the effect of aloe vera and nerium oleander on this enzyme activity were investigated. Xanthine oxidase activity in control liver tissue was decreased by aloe vera whereas nerium oleander was slightly increased it. It was shown that xanthine oxidase activity in liver tissue was inhibited by cyclosporine but, the inhibition was not prevented by aloe vera and nerium oleander.

Keywords

• Key Words: Aloe vera, nerium oleander, antimicrobial activity, xanthine oxidase, cyclosporine.

Abstract

Bu çalışmada aloevera ve nerium oleander bitkilerinin alkol, su ve kloroform fazlarına alınan ürünlerinin 8 farklı bakteri ve 2 maya olmak üzere 10 mikroorganizmaya karşı antimikrobiyal aktiviteleri araştırıldı. Aloe vera’nın nerium oleandere göre daha fazla antimikrobiyal aktivite gösterdiği görüldü. Kontrol ve siklosporinli karaciğer dokularındaki ksantin oksidaz enzim aktivitesi araştırıldı ve aloe vera ile nerium oleander’in bu enzim aktivitesine etkisi incelendi. Kontrol karaciğer dokusundaki ksantin oksidaz enzim aktivitesini aloe veranın azalttığı, nerium oleanderin ise az oranda artırdığı gözlendi. Siklosporinin karaciğer dokusundaki ksantin oksidaz enzim aktivitesini inhibe ettiği ve aloe vera ile nerium oleander’in bu inhibisyonu kaldıramadığı görüldü

Keywords

• Aloe vera, nerium oleander, antimikrobiyal aktivite, ksantin oksidaz, siklosporin

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