Some novel antimicrobial therapeutic agents for acetylcholinesterase inhibitors; synthesis of hydroxyquinoline ester involving amino acid
Abstract
The aim of this work was to investigate the new effective agents candidate for treatment of the Alzheimer’s disease. So, a series of new and highly active acetylcholinesterase inhibitors derived from hydroxyquinoline ester containing amino acid were synthesized. Antibacterial activities of the molecules were studied by the well-diffusion method against Listeria monocytogenes 4b, Staphylococcus aureus, Escherichia coli, Salmonella typhi H, Brucella abortus, Staphylococcus epidermis sp., Micrococcus luteus, Shigella dysenteria type 10, Bacillus cereus, Pseudomonas putida and antifungal activity against Candida albicans. All the synthesized compounds behave as inhibitors against AChE enzyme. CysEs and MetEs show more inhibition potency.
References
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Year 2015,
Volume: 28 Issue: 1, 11 - 19, 23.02.2015
Abstract
References
- Cavalli, S. and Cardellicchio, N., “Direct determination of seleno-amino acids in biological tissues electrochemical detection”, J. Chromatogr. A., 706(1- 2): 429- 436 (1995). separation and
- Garlick, P.J., “The nature of human hazards associated with excessive intake of amino acids”, J. Nutr., 134(6): 1633-1639 (2004).
- Sarı, N., Pişkin, N., Öğütcü, H. and Kurnaz, N., “Spectroscopic characterization of novel D-amino acid-Schiff bases and their Cr(III) and Ni(II) complexes as antimicrobial agents” Med. Chem. Res., 22: 580–587 (2013).
- Wang H, Carlier, P.R., Ho, W.L., Wu D.C., Lee N.T.K., Li C.P.L., Pang Y.P. and Han Y.F., “Effects of bis(7)-tacrine, a novel anti-Alzheimer’s agent, on rat brain AChE”, NeuroReport., 10: 789-793 (1999).
- Chen, W., “Clinical Applications of PET in Brain Tumors”, J. Nucl. Med., 48(9): 1468-1481 (2007).
- Carlier, P.R., Chow, E.S. H., Han, Y., Liu, J., Yazal, J.E. and Pang, Y.P., “Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand- peripheral site interactions”, J. Med. Chem, 42: 4225- 4231 (1999).
- Soscia, S. J., Kirby, J.E., Washicosky, K.J., Tucker, S.M., Ingelsson, M., Hyman, B., Burton, M.A., Goldstein, L.E., Duong, S., Tanzi, R.E. and Moir, R.D., “The Alzheimer’s Disease-associated amyloid β-protein is an antimicrobial peptide” PLoS ONE, 5(3): e9505 (2010).
- Jin, L., Sakiyan, I, Gonzales, N.S., Lane, D., Cherala, S., “Synthesis, characterization and Cu2+ binding studies of a l-histidine ester of 8-hydroxyquinoline” Inorg. Chim. Acta., 423: 72-78 (2014).
- Ellman, G.L., Courtney, K.D., Andres, V.J. and Featherstone, R.M., “A new and rapid colorimetric determination Biochem. Pharmacol., 7: 88-95 (1961). activity”,
- Silverstein, R.M., Bassler, G.C. and Morrill, T.C., Spectrophotometric compounds, 4th ed. Wiley, New York, (1981) of organic
- Sarı, N., Gürkan, P. and Arslan, S., “Synthesis, potentiometric and antimicrobial activity studies on 2-pyridinilidene-DL-amino complexes”, Trans. Met. Chem., 28: 468-474 (2003). acids and their A.,
- “Relationships between
- Beinert, H., Kennedy, M.C. and Stout C.D., “Aconitase as iron-sulfur protein, enzyme, and iron- regulatory protein” Chem. Rev., 96: 2335-2373 (1996).
- Reedijk, J., “Platinum anticancer coordination compounds: study of DNA binding inspires new drug design”, Eur. J. Inorg. Chem., 10: 1303-1312 (2009).
There are 14 citations in total.
Details
| Primary Language | English |
|---|---|
| Authors | |
| Publication Date | February 23, 2015 |
| Published in Issue | Year 2015 Volume: 28 Issue: 1 |