The Effects of Anatolian Black Pine Cone Extracts on Carbonic Anhydrase Enzymes

Year 2025, Early View, 1 - 1

Berfin Vapor , Ekrem Tunca

https://doi.org/10.35378/gujs.1416864

Abstract

Nowadays, there is an increasing trend in the use of natural products to treat diseases or alleviate their effects. This situation has emerged as a result of the side effect problem seen in the use of synthetic drugs. In this study, Anatolian black pine cone extracts were prepared using solvents of different polarities (water, methanol, ethanol, ethyl acetate, n-hexane). Then, the effects of these extracts on the esterase activities of hCA I and hCA II isoenzymes, which are associated with many physiological disorders, were examined in vitro. IC50 values were in the range of 5.10 to 49.50 μg/mL for hCA I and 2.57 to 15.07 μg/mL for hCA II. It can be said that these results are promising in terms of the potential of Anatolian black pine cone as a natural pharmacological agent.

Keywords

Anatolian black pine, Cone, Carbonic anhydrase, Esterase activity, Inhibition

Ethical Statement

There are no conflicts of interest.

Supporting Institution

The Scientific and Technological Research Council of Türkiye (TUBITAK)

Project Number

1919B012105233

Thanks

The authors would like to thank TUBITAK for supporting this study (grant number 1919B012105233).

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