Highlighting the Cosmeceutical Potential of the Edible Bunium alpinum Waldst& Kit (Apiaceae) Growing in Algeria: in vitro Antioxidant and Photoprotective Effects

Year 2023, Volume: 36 Issue: 1, 108 - 118, 01.03.2023

Mostefa Lefahal El-hani Makhloufı Radia Ayad Ahlem Boussetla Mohamed Elhattab Merve Keskin , Salah Akkal

https://doi.org/10.35378/gujs.1052131

Cited By: 1

Abstract

The interest of using natural ingredients in cosmetic products has getting increased specially developing in new photoprotective formulations. In this study, it was undertaken to evaluate the cosmeceutical potential of the aerial parts of the species Bunium alpinum Waldst. & Kit (Apiaceae family) growing Algeria, by assessing their photoprotective and antioxidant effects. For this purpose, the total antioxidant capacity and activity were determined by using phosphomolybdenum and DPPH· radical scavenging methods. The in vitro photoprotective effect against UV-B radiations was determined according to the Sun Protection Factor (SPF) by using UV spectrophotometer at the range between 290 and 320 nm and Mansur equation. It was clear that among the tested extract, content of phenolic compounds and flavonoids of butanolic extract (Ba-BuOH) had higher than other extracts and it possessed strong antioxidant activity in DPPH· radical scavenging (20.65±0.017 mg VCE/g) and total antioxidant activity (196.69±4.08 mg VCE/g) assays. Similarly, its major compound Apigenin-7-O-rutinoside exhibited high photoprotective activity in UVB and UVA range and the SPF values were (14.70±0.11 and 32.80±0.5, respectively). The results gathered from our work reveal the using possibility of this extract and its major as antioxidant and sunscreening agent in cosmetic formulations.

Keywords

Antioxidant activity, Bunium alpinum, Photoprotective activity, Sun protection factor, Ultraviolet visible- B

Thanks

The authors want to thank the MESRES and DGRSDT for the financial support.

References

• [1] Stevanato, R., Mariangela, B., Sabrina, F., "Photoprotective characteristics of natural antioxidant polyphenols", Regulatory Toxicology and Pharmacology, 69(1): 71-77, (2014).
• [2] Costa, S. C., Detoni, C. B., Branco, C. R., Botura, M. B., Branco, A., “In vitro photoprotective effects of Marcetia taxifolia ethanolic extract and its potential for sunscreen formulations”, Revista Brasileira de Farmacognosia, 25: 413-418, (2015).
• [3] Marto, J., Gouveia, L.F., Chiari, B. G., Paiva, A., Isaac, V., Pinto, P., Ribeiro, H. M., “The green generation of sunscreens: Using coffee industrial sub-products”, Industrial Crops and Products, 80: 93-100, (2016).
• [4] Joshi, L.S., Harshal A.P., "Herbal cosmetics and cosmeceuticals: An overview." Natural Product Chemical Research, 3(2): 170, (2015).
• [5] Lohani, A., Arun, K.M., Anurag, V., "Cosmeceutical potential of geranium and calendula essential oil: Determination of antioxidant activity and in vitro sun protection factor", Journal of Cosmetic Dermatology, 18(2): 550-557, (2019).
• [6] Thibane, V. S., Ndhlala, A. R., Abdelgadir, H. A., Finnie, J. F., Van Staden, J., “The cosmetic potential of plants from the Eastern Cape Province traditionally used for skincare and beauty”, South African Journal of Botany, 122: 475-483, (2019).
• [7] Tavares, A. C., Gonçalves, M. J., Cavaleiro, C., Cruz, M. T., Lopes, M. C., Canhoto, J., Salgueiro, L. R., “Essential oil of Daucus carota subsp. halophilus: composition, antifungal activity and cytotoxicity”, Journal of Ethnopharmacology, 119(1): 129-134, (2008).
• [8] Lefahal, M., Zaabat, N., Djarri, L., Benahmed, M., Kamel, M., Laouer, H., Akkal, S., “Evaluation of the antioxidant activity of extracts and flavonoids obtained from Bunium alpinum Waldst. & Kit.(Apiaceae) and Tamarix gallica L.(Tamaricaceae)”, Current Issues Pharmaceutical Medicine Science, 30(1): 5-8, (2017).
• [9] Boulacel, I., Harkati, B., Ayad, R., Demirtas, I., Laouer, H., Akkal, S., “Phytochemical studies antibacterial and antioxidant activities of aerial parts of Ferula lutea (Poir.) Maire”, Acta Scientifica Naturalis, 6(1): 17-25, (2019).
• [10] Hayet, E. K., Hocine, L., Meriem, E. K., “Chemical composition and biological activities of the essential oils and the methanolic extracts of Bunium incrassatum and Bunium alpinum from Algeria”, Journal of the Chilean Chemical Society, 62(1): 3335-3341, (2017).
• [11] Trifa, W., Akkal, S., Lefahal, M., Benmekhebi, L., Khennouf, S., “Preliminary screening of Nicotiana glauca extracts for determination of antioxidant activity by different methods”, Current Issues Pharmaceutical Medicine Science, 33(1): 32-37, (2020).
• [12] Ayad, R., Cakmak, Y. S., Ozusaglam, M. A., Medjroubi, K., Akkal, S., “In vitro antioxidant and antimicrobial activities of aerial parts of Algerian Jurinea humilis DC (Asteraceae)”, Tropical Journal of Pharmaceutical Research, 16(12): 2903-2909, (2017).
• [13] Almeida, M. M. B., de Sousa, P. H. M., Arriaga, Â. M. C., do Prado, G. M., de Carvalho Magalhães, C. E., Maia, G. A., de Lemos, T. L. G., “Bioactive compounds and antioxidant activity of fresh exotic fruits from northeastern Brazil”, Food Research International, 44(7): 2155-2159, (2011).
• [14] Cherfia, R., Zaiter, A., Akkal, S., Chaimbault, P., Abdelwahab, A. B., Kirsch, G., Chaouche, N. K., “New approach in the characterization of bioactive compounds isolated from Calycotome spinosa (L.) Link leaves by the use of negative electrospray ionization LITMSn, LC-ESI-MS/MS, as well as NMR analysis”, Bioorganic Chemistry, 96: 103535, (2020).
• [15] Félix, C., Félix, R., Carmona, A. M., Januário, A. P., Dias, P. D., Vicente, T. F., Lemos, M. F., “Cosmeceutical potential of grateloupia turuturu: Using low-cost extraction methodologies to obtain added-value extracts”, Applied Sciences, 11(4): 1650, (2021).
• [16] Acsova, A., Hojerova, J., Janotkova, L., Bendova, H., Jedličková, L., Hamranova, V., Martiniakova, S., “The real UVB photoprotective efficacy of vegetable oils: in vitro and in vivo studies”, Photochemical & Photobiological Sciences, 20(1): 139-151, (2021).
• [17] Correia, P., Araújo, P., Ribeiro, C., Oliveira, H., Pereira, A. R., Mateus, N., Fernandes, I., “Anthocyanin-related pigments: Natural allies for skin health maintenance and protection”, Antioxidants, 10(7): 1038, (2021).
• [18] Svobodová, A. R., Gabrielová, E., Michaelides, L., Kosina, P., Ryšavá, A., Ulrichová, J., Vostálová, J., “UVA-photoprotective potential of silymarin and silybin”, Archives of Dermatological Research, 310(5): 413-424, (2018).
• [19] Sayre, R. M., Agin, P. P., LeVee, G. J., Marlowe, E., “A comparison of in vivo and in vitro testing of sunscreening formulas”, Photochemistry and Photobiology, 29(3): 559-566, (1979).
• [20] Bourgou, S., Ksouri, R., Bellila, A., Skandrani, I., Falleh, H., Marzouk, B., “Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots”, Comptes Rendus Biologies, 331(1): 48-55, (2008).
• [21] Wang, M., Simon, J. E., Aviles, I. F., He, K., Zheng, Q. Y., Tadmor, Y., “Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.)”, Journal of Agricultural and Food Chemistry, 51(3): 601-608, (2003).
• [22] Hossain, M. D., Urbi, Z., Sule, A., Rahman, K. M., “Andrographis paniculata (Burm. f.) Wall. ex Nees: a review of ethnobotany, phytochemistry, and pharmacology”, The Scientific World Journal, (2014).
• [23] Fardiyah, Q., Ersam, T., Slamet, A., Kurniawan, F., “New potential and characterization of Andrographis paniculata L. Ness plant extracts as photoprotective agent”, Arabian Journal of Chemistry, 13(12): 8888-8897, (2020).
• [24] Zengin, G., Paksoy, M. Y., Aumeeruddy, M. Z., Glamocilja, J., Sokovic, M., Diuzheva, A., Mahomoodally, M. F., “New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species”, Food Research International, 123: 414-424, (2019).
• [25] Aryal, S., Baniya, M. K., Danekhu, K., Kunwar, P., Gurung, R., Koirala, N., “Total phenolic content, flavonoid content and antioxidant potential of wild vegetables from Western Nepal”, Plants, 8(4): 96, (2019).
• [26] Oztürk, N., Tunçel, M., Potoğlu Erkara, İ., "Phenolic compounds and antioxidant activities of some Hypericum species: A comparative study with H. perforatum", Pharmaceutical Biology, 47(2): 120-127, (2009).
• [27] Che, R. L., Wan, S. W.A., Asari, A, Mohd, R. R., “Correlatıon between TPC and TFC with antioxidant activity of Piper Sarmentosum extract and its formulatıon for cosmetıc purposes”, Universiti Malaysia Terengganu Journal of Undergraduate Research, 3(2): 51–60, (2021).
• [28] Hossain, M. I., Sharmin, F. A., Akhter, S., Bhuiyan, M. A., Shahriar, M., “Investigation of cytotoxicity and in-vitro antioxidant activity of Asparagus racemosus root extract”, International Current Pharmaceutical Journal, 1(9): 250-257, (2012).
• [29] Coruh, N., Celep, A. S., Özgökçe, F., “Antioxidant properties of Prangos ferulacea (L.) Lindl., Chaerophyllum macropodum Boiss. and Heracleum persicum Desf. from Apiaceae family used as food in Eastern Anatolia and their inhibitory effects on glutathione-S-transferase”, Food Chemistry, 100(3): 1237-1242, (2007).
• [30] Dehshiri, M. M., Aghamollaei, H., Zarini, M., Nabavi, S. M., Mirzaei, M., Loizzo, M. R., Nabavi, S. F., “Antioxidant activity of different parts of Tetrataenium lasiopetalum”, Pharmaceutical Biology, 51(8): 1081-1085, (2013).
• [31] Aguilar Toalá, J. E., Hernández Mendoza, A., González Córdova, A. F., Vallejo Cordoba, B., Liceaga, A. M., “Potential role of natural bioactive peptides for development of cosmeceutical skin products”, Peptides, 122: 170170, (2019).
• [32] Freitas, R., Martins, A., Silva, J., Alves, C., Pinteus, S., Alves, J., Pedrosa, R., “Highlighting the biological potential of the brown seaweed Fucus spiralis for skin applications”, Antioxidants, 9(7): 611, (2020).
• [33] de Oliveira Jr, R. G., Souza, G. R., Guimarães, A. L., de Oliveira, A. P., Morais, A. C. S., da Cruz Araújo, E. C., da Silva Almeida, J. R. G., “Dried extracts of Encholirium spectabile (Bromeliaceae) present antioxidant and photoprotective activities in vitro”, Journal of Young Pharmacists, 5(3): 102-105, (2013).
• [34] Lefahal, M., Zaabat, N., Ayad, R., Makhloufi, E. H., Djarri, L., Benahmed, M., Akkal, S., “In vitro assessment of total phenolic and flavonoid contents, antioxidant and photoprotective activities of crude methanolic extract of aerial parts of Capnophyllum peregrinum (L.) Lange (Apiaceae) growing in Algeria”, Medicines, 5(2): 26, (2018).
• [35] Amrani, A., Mecheri, A., Bensouici, C., Boubekri, N., Benaissa, O., Zama, D., Benayache, S., “Evaluation of antidiabetic, dermatoprotective, neuroprotective and antioxidant activities of Chrysanthemum fontanesii flowers and leaves extracts”, Biocatalysis and Agricultural Biotechnology, 20: 101209, (2019).
• [36] Mouffouk, C., Mouffouk, S., Oulmi, K., Mouffouk, S., Haba, H., “In vitro photoprotective, hemostatic, anti-inflammatory and antioxidant activities of the species Linaria scariosa Desf.”, South African Journal of Botany, 130: 383-388, (2020).
• [37] Yakoubi, R., Megateli, S., Sadok, T. H., Gali, L., “Photoprotective, antioxidant, anticholinesterase activities and phenolic contents of different Algerian Mentha pulegium extracts”, Biocatalysis and Agricultural Biotechnology, 34: 102038, (2021).
• [38] Lefahal, M., Makhloufi, E. H., Trifa, W., Ayad, R., El Hattab, M., Benahmed, M., Keskin, M., Akkal, S., “The cosmetic potential of the medicinal halophyte Tamarix Gallica L. (Tamaricaceae) growing in the eastern part of Algeria: Photoprotective and antioxidant activities”, Combinatorial Chemistry & High Throughput Screening, 24(10): 1671-1678, (2021).
• [39] Rodrigues, F. A. M., Giffony, P. S., dos Santos, S. B., Guedes, J. A., Ribeiro, M. E. N., Araújo, T. G. D., Ricardo, N. M., “Spondias purpurea L. Stem Bark Extract: Antioxidant and in vitro photoprotective activities”, Journal of the Brazilian Chemical Society, 32: 1918-1930, (2021).
• [40] Sabzevari, N., Qiblawi, S., Norton, S. A., Fivenson, D., “Sunscreens: UV filters to protect us: Part 1: Changing regulations and choices for optimal sun protection”, International Journal of Women's Dermatology, 7(1): 28-44, (2021).