The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography

Y Aboul-enein; Abdalla Elbashır; Fakhr Sulıman

Research Article

Year 2011, Volume: 24 Issue: 4, 679 - 697, 08.07.2011

Y Aboul-enein Abdalla Elbashır Fakhr Sulıman

Abstract

References

Analytical column was a monolithic-ODS column (750mm×0.53mm I.D., prepare in a fused silica capillary, provided from Shiseido) elution:isocratic, eluent: for NBD-Ser was MeCN– TFA–water (5:0.05:95, v/v/v), and that for NBD-Ala was MeCN–TFA–water (15:0.05:85, v/v/v). Sumichiral OA-2500 (S) and (R) (250 4.6 mm i.d.), Elution; isocratic Eluent: 20 mm citric acid in MeOHُ analytical column for the reversed-phase separation was a Capcell pak C18 MG II (150 mm × 1.0 mm
Shiseido) elution:isocratic, elutent: THF–TFA–water (25/0.05/75, v/v/v) For enantiomer separations, Chiralpak QN-AX and Chiralpak QD-AX (150 mm × 4.0 mm I.D., Chiral Technologies Europe, Illkirch, France): 10 mM citric acid in the mixed solution of MeOH–MeCN (50/50, v/v) Sample + 20 µl of mM borate buffer (pH 8.0) + 10 µl of 20 mM analytical column for the reversed-phase separation was a Mightysil RP-18 GP (100 mm × 1.0 mm I.D., Kanto Chemical, Tokyo, Japan), elution:isocratic, eluent: MeCN– THF–TFA–water (10:1:0.02:89, v/v) enantioselective column was a Sumichiral OA-2500S
Chemical Analysis Service, Osaka, Japan) 5 mM citric acid in MeOH microbore-monolithic-ODS column I.D.) elution: isocratic, eluent: NBD-Ser was MeCN–TFA– water (5:0.05:95, v/v/v) a self-packed narrowbore-Pirkle type enantioselective column (Sumichiral OA-2500S, citric acid in MeOH–MeCN (50:50, v/v), analytical column a microbore- monolithic ODS column (1000 mm × 0.53 mm prepared in a fused silica capillary, provided from
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The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography

Year 2011, Volume: 24 Issue: 4, 679 - 697, 08.07.2011

Y Aboul-enein Abdalla Elbashır Fakhr Sulıman

Abstract

This paper reviews analytical methods, instrumental developments and applications for derivatization of amines and amino acids with 7-Chloro-4-nitrobenzoxadiazole (NBD-Cl) and 4-Fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) using high performance liquid chromatography (HPLC). Discussion of the literature related to the application from 2001 to 2010 is presented.

Keywords

NBD-Cl, NBD-F, HPLC, 2D-HPLC, Amines and Amino acids

References

Analytical column was a monolithic-ODS column (750mm×0.53mm I.D., prepare in a fused silica capillary, provided from Shiseido) elution:isocratic, eluent: for NBD-Ser was MeCN– TFA–water (5:0.05:95, v/v/v), and that for NBD-Ala was MeCN–TFA–water (15:0.05:85, v/v/v). Sumichiral OA-2500 (S) and (R) (250 4.6 mm i.d.), Elution; isocratic Eluent: 20 mm citric acid in MeOHُ analytical column for the reversed-phase separation was a Capcell pak C18 MG II (150 mm × 1.0 mm
Shiseido) elution:isocratic, elutent: THF–TFA–water (25/0.05/75, v/v/v) For enantiomer separations, Chiralpak QN-AX and Chiralpak QD-AX (150 mm × 4.0 mm I.D., Chiral Technologies Europe, Illkirch, France): 10 mM citric acid in the mixed solution of MeOH–MeCN (50/50, v/v) Sample + 20 µl of mM borate buffer (pH 8.0) + 10 µl of 20 mM analytical column for the reversed-phase separation was a Mightysil RP-18 GP (100 mm × 1.0 mm I.D., Kanto Chemical, Tokyo, Japan), elution:isocratic, eluent: MeCN– THF–TFA–water (10:1:0.02:89, v/v) enantioselective column was a Sumichiral OA-2500S
Chemical Analysis Service, Osaka, Japan) 5 mM citric acid in MeOH microbore-monolithic-ODS column I.D.) elution: isocratic, eluent: NBD-Ser was MeCN–TFA– water (5:0.05:95, v/v/v) a self-packed narrowbore-Pirkle type enantioselective column (Sumichiral OA-2500S, citric acid in MeOH–MeCN (50:50, v/v), analytical column a microbore- monolithic ODS column (1000 mm × 0.53 mm prepared in a fused silica capillary, provided from
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Details

Primary Language	English
Subjects	Engineering
Journal Section	Chemistry
Authors	Y Aboul-enein This is me Abdalla Elbashır This is me Fakhr Sulıman This is me
Publication Date	July 8, 2011
Published in Issue	Year 2011 Volume: 24 Issue: 4

Cite

APA	Aboul-enein, Y., Elbashır, A., & Sulıman, F. (2011). The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography. Gazi University Journal of Science, 24(4), 679-697.
AMA	Aboul-enein Y, Elbashır A, Sulıman F. The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography. Gazi University Journal of Science. December 2011;24(4):679-697.
Chicago	Aboul-enein, Y, Abdalla Elbashır, and Fakhr Sulıman. “The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography”. Gazi University Journal of Science 24, no. 4 (December 2011): 679-97.
EndNote	Aboul-enein Y, Elbashır A, Sulıman F (December 1, 2011) The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography. Gazi University Journal of Science 24 4 679–697.
IEEE	Y. Aboul-enein, A. Elbashır, and F. Sulıman, “The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography”, Gazi University Journal of Science, vol. 24, no. 4, pp. 679–697, 2011.
ISNAD	Aboul-enein, Y et al. “The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography”. Gazi University Journal of Science 24/4 (December 2011), 679-697.
JAMA	Aboul-enein Y, Elbashır A, Sulıman F. The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography. Gazi University Journal of Science. 2011;24:679–697.
MLA	Aboul-enein, Y et al. “The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography”. Gazi University Journal of Science, vol. 24, no. 4, 2011, pp. 679-97.
Vancouver	Aboul-enein Y, Elbashır A, Sulıman F. The Application of 7-Chloro-4-Nitrobenzoxadiazole and 4-Fluoro-7-Nitro-2,1,3-Benzoxadiazole for The Analysis of Amines and Amino Acids Using High-Performance Liquid Chromatography. Gazi University Journal of Science. 2011;24(4):679-97.

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