The Effects on Antioxidant Enzyme Systems in Rat Brain Tissues of Lead Nitrate and Mercury Chloride

Year 2015, Volume: 28 Issue: 2, 169 - 174, 22.06.2015

Hatice Baş , Suna Kalender , Hatice Karaboduk Fatma Apaydın

Abstract

The present study was undertaken to evaluate the effects of lead nitrate and mercury chloride in brain tissues of Wistar rats. Mercury chloride (0.02 mg/kg bw) and lead nitrate (45 mg/kg bw) were administered orally for 28 days rats. The mercury chloride and lead nitrate treated animals were exhibited a significant inhibition of superoxide dismutase, catalase, glutation peroxidase and glutathione-S-transferase activities and increasing of malondialdehyde levels. In our present study mercury chloride caused more harmful effects than lead nitrate. The effect which we observed applying the lead nitrate and mercury chloride together, was more greater than when we used them alone.

Keywords

Lead nitrate, mercury chloride, oxidative stress, brain

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