Paracetamol is a popular analgesic drug and its overdose may cause toxicity in the kidney. Prunus laurocerasus L. (PL) is an important folklore medicinal plant that has antioxidant properties. This study explores effects of PL fruit water and ethanol-water extracts administrations on oxidative stress in paracetamol-induced nephrotoxicity. For this purpose, 30 rats were divided into 5 groups: control, negative control (2 g/kg paracetamol), PL fruit water extract (400 mg/kg PLW+ 2 g/kg paracetamol), PL fruit ethanol-water extract (400 mg/kg PLEW+ 2 g/kg paracetamol) and positive control (150 mg/kg NAC+ 2 g/kg paracetamol). 24 hours after the paracetamol induction, animals were sacrificed and oxidative parameters were analyzed spectrophotometrically in kidney tissue. PLW and PLEW extracts decreased MDA and NOx levels and increased SOD and CAT activities in paracetamol-induced nephrotoxicity. PL fruit extracts can restore the oxidative changes caused by paracetamol.
Antioxidants Nephrotoxicity Oxidative stress Paracetamol Prunus laurocerasus
The author thanks to Dr. O. Aydin Berktas and Dr. E. G. Gulec Peker for their kind support in the study.
Birincil Dil | İngilizce |
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Bölüm | Research Articles |
Yazarlar | |
Yayımlanma Tarihi | 31 Aralık 2022 |
Gönderilme Tarihi | 12 Ağustos 2022 |
Yayımlandığı Sayı | Yıl 2022 Cilt: 9 Sayı: 4 |
Hittite Journal of Science and Engineering Creative Commons Atıf-GayriTicari 4.0 Uluslararası Lisansı (CC BY NC) ile lisanslanmıştır.