Evaluation of Antioxidant Activity of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Abstract

The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA. The most pronounced AOA has 4-amino-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol. It was found that in most cases the introduction in alkyl-derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles free amino group or phenyl substituent to the N4 atom of the 1,2,4-triazole nucleus, accompanied with increasing of AOA for test substances. In almost all cases, the presence on the N4 atom of 1,2,4-triazole nucleus methyl or ethyl groups has the opposite effect, even in comparison with control groups.

Keywords

• 1.2.4-triazole
• antioxidant activity
• in vitro method

Supporting Institution

The Ministry of Education and Science of Ukraine

Project Number

0120U101649

Thanks

The authors are highly thankful to the The Ministry of Education and Science of Ukraine for financial support which was given according to scientific topic № 0120U101649 "Synthesis, modification and study of the properties of 1,2,4-triazole derivatives for the purpose of antimicrobial drug production".

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