Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats

Year 2023, , 333 - 339, 01.12.2023

Volodymyr Shvets , Hanna Maslak , Vadim Davydov , Halyna Berest , Inna Nosulenko , Oleksii Voskoboinik , Liudmyla Omelianchyk , Oleksandr Brazhko

https://doi.org/10.52794/hujpharm.1269999

Abstract

The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old (22–25 months) animals. It was established, that the injection of the extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited sensitivity of the heart muscle’s CPK-MT to damaging stress factors (reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes), and helps the normalization of its kinetic properties, has an influence on the myocardium’s kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.

Keywords

stress, myocardium, aging, Aronia melanocarpa extract, mitochondrial creatine kinase.

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