Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma

Merve Nenni; Tuğba Tehçi

doi:10.52794/hujpharm.1669708

Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma

Abstract

Melasma, a condition causing uneven brown patches on the forehead, cheeks, and chin, is classified into epidermal, dermal, mixed, and indeterminate types. Treatment options include tranexamic acid (TXAA), which has been increasingly used recently. The 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay is a widely accepted and often employed test for quantifying the overall antioxidant capacity of substances. The DPPH method was used to calculate the antioxidant scavenging percentages of TXAA and ascorbic acid (vitamin C). TXAA showed a DPPH radical scavenging activity of 60.77±0.34% at 50,000 ppm, while ascorbic acid showed a DPPH radical scavenging activity of 95.77±0.59% at 1000 ppm. Ascorbic acid is a known powerful antioxidant. After examining the results, it is clear that TXAA exhibits antioxidant activity, although it is less potent than the antioxidant effect of ascorbic acid.

Keywords

Supporting Institution

No funding

Ethical Statement

This study does not require ethics committee approval.

Thanks

No need for thanks

References

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Details

Primary Language

English

Subjects

Pharmaceutical Analytical Chemistry

Journal Section

Research Article

Authors

Merve Nenni ^*
0000-0003-3165-1060
Türkiye

Tuğba Tehçi
0000-0002-8588-4292
Türkiye

Publication Date

December 1, 2025

Submission Date

April 3, 2025

Acceptance Date

August 15, 2025

Published in Issue

Year 2025 Volume: 45 Number: 4

DOI

https://doi.org/10.52794/hujpharm.1669708

IZ

https://izlik.org/JA23EP86NY

Cite

RIS / Bibtex

APA

Nenni, M., & Tehçi, T. (2025). Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma. Hacettepe University Journal of the Faculty of Pharmacy, 45(4), 338-344. https://doi.org/10.52794/hujpharm.1669708

AMA

1.Nenni M, Tehçi T. Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma. HUJPHARM. 2025;45(4):338-344. doi:10.52794/hujpharm.1669708

Chicago

Nenni, Merve, and Tuğba Tehçi. 2025. “Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma”. Hacettepe University Journal of the Faculty of Pharmacy 45 (4): 338-44. https://doi.org/10.52794/hujpharm.1669708.

EndNote

Nenni M, Tehçi T (December 1, 2025) Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma. Hacettepe University Journal of the Faculty of Pharmacy 45 4 338–344.

IEEE

[1]M. Nenni and T. Tehçi, “Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma”, HUJPHARM, vol. 45, no. 4, pp. 338–344, Dec. 2025, doi: 10.52794/hujpharm.1669708.

ISNAD

Nenni, Merve - Tehçi, Tuğba. “Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma”. Hacettepe University Journal of the Faculty of Pharmacy 45/4 (December 1, 2025): 338-344. https://doi.org/10.52794/hujpharm.1669708.

JAMA

1.Nenni M, Tehçi T. Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma. HUJPHARM. 2025;45:338–344.

MLA

Nenni, Merve, and Tuğba Tehçi. “Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma”. Hacettepe University Journal of the Faculty of Pharmacy, vol. 45, no. 4, Dec. 2025, pp. 338-44, doi:10.52794/hujpharm.1669708.

Vancouver

1.Merve Nenni, Tuğba Tehçi. Tranexamic Acid in Dermatology: Exploring Its Antioxidant Activity and Therapeutic Potential for Melasma. HUJPHARM. 2025 Dec. 1;45(4):338-44. doi:10.52794/hujpharm.1669708